Abstract:
:Gastric cancer is the fifth most common cancer and the third leading cause of cancer-related death, whose patterns vary among geographical regions and ethnicities. It is a multifactorial disease, and its development depends on infection by Helicobacter pylori (H. pylori) and Epstein-Barr virus (EBV), host genetic factors, and environmental factors. The heterogeneity of the disease has begun to be unraveled by a comprehensive mutational evaluation of primary tumors. The low-abundance of mutations suggests that other mechanisms participate in the evolution of the disease, such as those found through analyses of noncoding genomics. Noncoding genomics includes single nucleotide polymorphisms (SNPs), regulation of gene expression through DNA methylation of promoter sites, miRNAs, other noncoding RNAs in regulatory regions, and other topics. These processes and molecules ultimately control gene expression. Potential biomarkers are appearing from analyses of noncoding genomics. This review focuses on noncoding genomics and potential biomarkers in the context of gastric cancer and the gastric precancerous cascade.
journal_name
Dis Markersjournal_title
Disease markersauthors
Sandoval-Bórquez A,Saavedra K,Carrasco-Avino G,Garcia-Bloj B,Fry J,Wichmann I,Corvalán AHdoi
10.1155/2015/503762subject
Has Abstractpub_date
2015-01-01 00:00:00pages
503762eissn
0278-0240issn
1875-8630journal_volume
2015pub_type
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