ENDOCRINOLOGY IN THE TIME OF COVID-19: Management of hyperthyroidism and hypothyroidism.

abstract：:The two pituitary gonadotrophins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and in particular LH-stimulated high intratesticular testosterone (ITT) concentration, are considered crucial for spermatogenesis. We have revisited these concepts in genetically modified mice, one being the LH receptor ...

journal_title：European journal of endocrinology

authors： Huhtaniemi I

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:X-linked adrenoleukodystrophy (X-ALD) is the most frequent, severely neurodegenerative, clinically heterogeneous peroxisomal disorder, the signs of which are a consequence of myelin, adrenal cortex, and testes impairment. OBJECTIVE:We studied testosterone, LH, and FSH levels in X-ALD/adrenomyeloneuropathy (...

journal_title：European journal of endocrinology

authors： Stradomska TJ,Kubalska J,Janas R,Tylki-Szymanska A

更新日期：2012-02-01 00:00:00

abstract：:Pyridostigmine (PST), a cholinesterase inhibitor, induces a clear growth hormone (GH) release in man by suppression of hypothalamic somatostatin (SRIH). Somatostatin suppresses thyrotrophin (TSH) release in rats and men. Earlier studies showed that the thryotrophin-releasing hormone (TRH)-induced TSH response was not ...

journal_title：European journal of endocrinology

authors： Yang I,Woo J,Kim S,Kim J,Kim Y,Choi Y

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of Rosiglitazone in three patients treated with bilateral adrenalectomy followed by hyperpigmentation and hypersecretion of ACTH. PATIENTS AND METHODS:One patient had increasing ACTH after previous transsphenoidal surgery for Nelson's syndrome, and two patients without pituitary ade...

journal_title：European journal of endocrinology

authors： Andreassen M,Kristensen LØ

更新日期：2005-10-01 00:00:00

abstract：INTRODUCTION:Activating mutations of the BRAF oncogene are frequently detected in papillary thyroid carcinoma (PTC) and have been associated with a worse prognosis. The amino acid substitution V600E accounts for 90% of all oncogenic BRAF mutations and is typically detected in classic PTCs, whereas other less frequent B...

journal_title：European journal of endocrinology

authors： Barzon L,Masi G,Boschin IM,Lavezzo E,Pacenti M,Casal Ide E,Toniato A,Toppo S,Palù G,Pelizzo MR

更新日期：2008-07-01 00:00:00

abstract：:The strategy for diagnosis of primary aldosteronism (PA) in the hypertensive population includes firstly a screening step, based on the measurement of plasma aldosterone-to-renin ratio (ARR), a test which must have high sensitivity, and secondly a confirmatory step based on the demonstration of excessive aldosterone p...

journal_title：European journal of endocrinology

authors： Morera J,Reznik Y

更新日期：2019-02-01 00:00:00

abstract：:The episodicity of 24 h GH release was studied in 18 patients with active acromegaly, 12 patients 7-10 days after pituitary surgery, 14 patients long after operation (3-17 years), and 21 healthy gender- and age-matched control subjects, using a recently introduced scale- and model-independent regularity statistic, app...

journal_title：European journal of endocrinology

authors： van den Berg G,Pincus SM,Frölich M,Veldhuis JD,Roelfsema F

更新日期：1998-02-01 00:00:00

abstract：:The reproductive hormonal profile was evaluated in female rats with experimental nephrotic syndrome induced with a single subcutaneous dose of puromycin aminonucleoside (PAN). Serum concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone (P4), testosterone and 17 beta-estradiol (E2...

journal_title：European journal of endocrinology

authors： Menjívar M,Vilchis F,Cárdenas M,Cruz C,Merchant H,Pérez-Palacios G,Pedraza-Chaverri J

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVE:In female adrenal insufficiency, dehydroepiandrosterone (DHEA) secretion is impaired and circulating androgen levels are severely reduced. We wanted to analyse the acute effects of physiological DHEA substitution on substrate metabolism. DESIGN:We studied nine females with adrenal insufficiency after 9 days ...

journal_title：European journal of endocrinology

authors： Christiansen JJ,Gravholt CH,Fisker S,Møller N,Andersen M,Svenstrup B,Bennett P,Ivarsen P,Christiansen JS,Jørgensen JO

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:Investigation of small numbers of parathyroid tumours by X-chromosome inactivation analysis suggests that the majority of them are monoclonal lesions most likely caused by a somatic mutation. Somatic mutations in the MEN1 gene located on chromosome 11q13 have recently been identified in 12-17% of solitary pa...

journal_title：European journal of endocrinology

authors： Miedlich S,Krohn K,Lamesch P,Müller A,Paschke R

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVES:The French Acromegaly Registry records data of acromegalic patients' since 1992 in French, Belgian (Liège), and Swiss (Lausanne) centers. We studied the prevalence of diabetes in this population looking for risk factors. Patients from one of the centers (Reims) were then analyzed more thoroughly. METHODS:Th...

journal_title：European journal of endocrinology

authors： Fieffe S,Morange I,Petrossians P,Chanson P,Rohmer V,Cortet C,Borson-Chazot F,Brue T,Delemer B,French Acromegaly Registry.

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:Secreted protein acidic and rich in cysteine (SPARC) also known as BM-40 which has been studied in various pathological conditions, has recently been suggested as a key player in the pathology of obesity and type 2 diabetes mellitus (T2DM). However, there are few studies on putative pathophysiologic roles of ...

journal_title：European journal of endocrinology

authors： Wu D,Li L,Yang M,Liu H,Yang G

更新日期：2011-10-01 00:00:00

abstract：:Signalling of receptor activator of nuclear factor-κB (RANK) ligand (RANKL) through RANK is a critical pathway to regulate the differentiation and activity of osteoclasts and, hence, a master regulator of bone resorption. Increased RANKL activity has been demonstrated in diseases characterised by excessive bone loss s...

journal_title：European journal of endocrinology

authors： Tsourdi E,Rachner TD,Rauner M,Hamann C,Hofbauer LC

更新日期：2011-12-01 00:00:00

abstract：:Glucose is the main substrate utilized by the brain and as such multiple regulatory mechanisms exist to maintain glucose concentrations. When these mechanisms fail or are defective, hypoglycemia ensues. Due to these robust mechanisms, hypoglycemia is uncommon and usually occurs in the setting of the treatment of diabe...

journal_title：European journal of endocrinology

authors： Kittah NE,Vella A

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:Increased reverse tritiodothyronine (T(3)) used to be described as a part of euthyroid sick syndrome (ESS). It was demonstrated to be associated with increased mortality in acutely ill patients. It can also be found with low or normal T(3) in non-severely ill subjects but its significance remains unclear. PA...

journal_title：European journal of endocrinology

authors： Forestier E,Vinzio S,Sapin R,Schlienger JL,Goichot B

更新日期：2009-02-01 00:00:00

abstract：:The objective was to compare the changes in prostaglandin synthesis and metabolism occurring within the fetal membranes that are associated with the onset of parturition and to study the effect of steroid hormones on prostaglandin metabolism. A tissue explant study was made of discs of amnion and chorion obtained from...

journal_title：European journal of endocrinology

authors： Brennand JE,Leask R,Kelly RW,Greer IA,Calder AA

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVE:In hyperthyroidism, tissue glucose disposal is increased to adapt to high energy demand. Our aim was to examine the regulation of glucose transporter (GLUT) isoforms by IGF-I in monocytes from patients with hyperthyroidism. DESIGN AND METHODS:Blood (20 ml) was drawn from 21 healthy and 10 hyperthyroid subjec...

journal_title：European journal of endocrinology

authors： Dimitriadis G,Maratou E,Boutati E,Kollias A,Tsegka K,Alevizaki M,Peppa M,Raptis SA,Hadjidakis DJ

更新日期：2008-03-01 00:00:00

abstract：Objectives:We investigated the clinical significance of ACTH stimulation during adrenal venous sampling (AVS) by surgical outcome of primary aldosteronism (PA). Design:Multicenter retrospective study by Japan PA study. Method:We allocated 314 patients with both basal and ACTH-stimulated AVS data who underwent adrenal...

journal_title：European journal of endocrinology

authors： Kobayashi H,Nakamura Y,Abe M,Kurihara I,Itoh H,Ichijo T,Takeda Y,Yoneda T,Katabami T,Tsuiki M,Wada N,Ogawa Y,Sakamoto R,Kawashima J,Sone M,Inagaki N,Yoshimoto T,Yamada T,Okamoto R,Matsuda Y,Fujita M,Watanabe M,

更新日期：2020-03-01 00:00:00

abstract：:Ionomycin, which mobilizes Ca2+, and phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), were used to compare the effects/interactions of Ca2+ and PKC on luteinizing hormone (LH) secretion from pituitaries of intact male and acutely ovariectomized (72 h) rats. Quartered pituitaries from dono...

journal_title：European journal of endocrinology

authors： Das S,Fahmy NW,Bourne GA

更新日期：1994-02-01 00:00:00

abstract：:Tall stature is defined as a height of more than 2 standard deviations (s.d.) above average for same sex and age. Tall individuals are usually referred to endocrinologists so that hormonal disorders leading to abnormal growth are excluded. However, the majority of these patients have familial tall stature or constitut...

journal_title：European journal of endocrinology

authors： Albuquerque EVA,Scalco RC,Jorge AAL

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:Our purpose was to study the sex steroid-mediated changes in serum insulin and lipid concentrations in boys during puberty. DESIGN AND METHODS:We treated boys with constitutional delay of puberty either with testosterone plus placebo or with testosterone plus an aromatase inhibitor, letrozole, which inhibits...

journal_title：European journal of endocrinology

authors： Wickman S,Saukkonen T,Dunkel L

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVE:Cushing's disease (CD) is usually caused by ACTH-secreting pituitary microadenomas, while silent corticotroph adenomas (SCA) are macroadenomas without Cushingoid features. However, the molecular mechanism(s) underlying their different tumor growth remains unknown. The aim of the current study was to evaluate ...

journal_title：European journal of endocrinology

authors： Tani Y,Inoshita N,Sugiyama T,Kato M,Yamada S,Shichiri M,Hirata Y

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:Adrenaline inhibits insulin secretion through activation of alpha(2)-adrenoceptors (ARs). These receptors are linked to pertussis toxin-sensitive G proteins. Agonist binding leads to inhibition of adenylyl cyclase, inhibition of Ca(2+) channels and activation of K(+) channels. Recently, three distinct subtype...

journal_title：European journal of endocrinology

authors： Peterhoff M,Sieg A,Brede M,Chao CM,Hein L,Ullrich S

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:The evidence that stress may provoke Graves' hyperthyroidism in genetically susceptible subjects is substantial. Whether exposure to stress is related to the severity of thyrotoxicosis has not been studied. Advancing age is associated with not only less severe Graves' hyperthyroidism but also self-reported st...

journal_title：European journal of endocrinology

authors： Vos XG,Smit N,Endert E,Brosschot JF,Tijssen JG,Wiersinga WM

更新日期：2009-02-01 00:00:00

abstract：:Approximately 15 million babies are born preterm across the world every year, with less than 37 completed weeks of gestation. Survival rates increased during the last decades with the improvement of neonatal care. With premature birth, babies are deprived of the intense intrauterine growth phase, and postnatal growth ...

journal_title：European journal of endocrinology

authors： Boguszewski MCDS,Cardoso-Demartini AA

更新日期：2017-03-01 00:00:00

abstract：CONTEXT:There is evidence to suggest that IGF-I plays a role in regulating bone turnover. OBJECTIVE:To evaluate the relationships between serum concentrations of IGF-I and IGF-binding protein-3 (IGFBP-3), and bone metabolism markers in healthy children. DESIGN AND SETTING:Prospective cross-sectional study. SUBJECTS ...

journal_title：European journal of endocrinology

authors： Léger J,Mercat I,Alberti C,Chevenne D,Armoogum P,Tichet J,Czernichow P

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:Congenital hypothyroidism (CH), the most common neonatal metabolic disorder, is characterized by impaired neurodevelopment. Although several candidate genes have been associated with CH, comprehensive screening of causative genes has been limited. DESIGN AND METHODS:One hundred ten patients with primary CH w...

journal_title：European journal of endocrinology

authors： Sun F,Zhang JX,Yang CY,Gao GQ,Zhu WB,Han B,Zhang LL,Wan YY,Ye XP,Ma YR,Zhang MM,Yang L,Zhang QY,Liu W,Guo CC,Chen G,Zhao SX,Song KY,Song HD

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated a high prevalence of thyroperoxidase antibodies (TPOAb) and autoimmune hypothyroidism in breast cancer (BC). These studies have been performed in BC patients generally 20-30 days after mastectomy. It is known that stress may have an influence on the immune system and a rela...

journal_title：European journal of endocrinology

authors： Giustarini E,Pinchera A,Fierabracci P,Roncella M,Fustaino L,Mammoli C,Giani C

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:In inflammatory bowel diseases, increased serum interleukin (IL)-6 levels are associated with high serum insulin-like growth factor-binding protein 2 (IGFBP-2) levels, and cytokines modify the insulin-like growth factor (IGF)/IGFBP system in models in vitro. In cystic fibrosis (CF) the IGF/IGFBP system has no...

journal_title：European journal of endocrinology

authors： Street ME,Ziveri MA,Spaggiari C,Viani I,Volta C,Grzincich GL,Virdis R,Bernasconi S

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Primary aldosteronism (PA) is the most common form of secondary hypertension, while Gitelman's syndrome (GS) is the most common inherited renal tubular disease. However, coexistence of these two diseases has never been previously reported. AIM AND SUBJECTS: The aim of our study was to describe the associatio...

journal_title：European journal of endocrinology

authors： Miao Z,Gao Y,Bindels RJ,Yu W,Lang Y,Chen N,Ren H,Sun F,Li Y,Wang X,Shao L

更新日期：2009-08-01 00:00:00