Abstract:
BACKGROUND AND OBJECTIVES:Attention-deficit/hyperactivity disorder (ADHD) medication use and psychotherapeutic polypharmacy is increasing. This study was designed to assess annual rates of ADHD medication prescribing and psychotherapeutic polypharmacy among patients 2 to 24 years old in the United States, identify commonly prescribed ADHD medications and concomitant psychotropic agents, and assess if specific characteristics are associated with polypharmacy. METHODS:In this cross-sectional study, we used publicly available ambulatory health care data sets to evaluate ADHD and psychotropic polypharmacy use in patients 2 to 24 years old from 2006 to 2015. National rates were estimated by using sampling weights, and common ADHD and psychotropic drugs prescribed were identified. Multivariate logistic regression models were developed to assess the strength of association between polypharmacy and patient or provider characteristics. RESULTS:Between 2006 and 2015, ADHD medication prescribing increased from 4.8% to 8.4%. ADHD polypharmacy increased from 16.8% to 20.5%, whereas psychotropic polypharmacy increased from 26.0% to 40.7%. The most common ADHD combinations were stimulants and α-2 agonists (67.1%), whereas the most common concomitant psychotropic agents were selective serotonin reuptake inhibitors (14.4%) and second-generation antipsychotics (11.8%). Factors associated with polypharmacy were age, female sex (psychotropic), nonprivate insurance, northeast and south regions (ADHD), receipt of mental health counseling or psychotherapy, and calendar year. CONCLUSIONS:ADHD and psychotropic polypharmacy use is increasing and associated with specific patient characteristics. These patterns should spark further inquiry about the appropriateness, efficacy, and safety of psychotherapeutic polypharmacy in children and young adults, particularly within subgroups in which the use is high.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Girand HL,Litkowiec S,Sohn Mdoi
10.1542/peds.2019-2832subject
Has Abstractpub_date
2020-07-01 00:00:00issue
1eissn
0031-4005issn
1098-4275pii
peds.2019-2832journal_volume
146pub_type
杂志文章相关文献
PEDIATRICS文献大全abstract:OBJECTIVE:Sensitization to perennial aeroallergens is associated with asthma in industrialized countries with a Western lifestyle. Because silk products are commonly used in Chinese society, we were interested in examining the relation between sensitization to silk and asthma. DESIGN:Cross-sectional study of 871 child...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.107.5.e80
更新日期:2001-05-01 00:00:00
abstract::Recently, a 7-month-old, terminally ill Gypsy infant was admitted to a pediatric intensive care unit. Treating this child and her extended family was a challenging experience during which numerous culture-related problems were encountered. The Gypsy approach to acute medical care consisted of the presence of a large e...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1983-11-01 00:00:00
abstract::Nineteen children with rheumatic diseases refractory to standard treatment were given repeated large "pulses" of corticosteroid therapy. The pulses consisted of four repeated doses of 500 mg of hydrocortisone given intravenously over 20 to 30 minutes at six-hour intervals or of single intravenous injections of 30 mg/k...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1980-05-01 00:00:00
abstract:OBJECTIVE:Croup is the most common form of airway obstruction in children. Known to be primarily viral, the seasonality of croup has been examined largely through its association with the human parainfluenza viruses. This study examined the seasonal pattern of croup hospitalizations in relation to age and gender for th...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-1892
更新日期:2005-07-01 00:00:00
abstract::In recent years, next-generation sequencing technologies have revolutionized approaches to genetic studies. Whole-exome or whole-genome sequencing allows diagnoses in many patients who have complex phenotypes and unusual clinical presentations. As genomic and exomic testing expands in both the research and clinical se...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2015-3731C
更新日期:2016-01-01 00:00:00
abstract::Over-the-counter (OTC) cough and cold medications are marketed widely for relief of common cold symptoms, and yet studies have failed to demonstrate a benefit of these medications for young children. In addition, OTC medications can be associated with significant morbidity and even mortality in both acute overdoses an...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.108.3.e52
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVE:To examine clinician-reported diagnosis of obesity and frequency of blood pressure assessment and diet and exercise counseling during ambulatory visits made by children and adolescents. METHODS:The National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey 1997 to 2000 were ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-1517
更新日期:2005-07-01 00:00:00
abstract::The package inserts of live viral vaccines include immunodeficiency as a contraindication. Nevertheless, patients with mild forms of immunodeficiency may benefit from vaccination. No published guidelines exist for the administration of these vaccines specifically to patients with chromosome 22q11.2 deletion syndrome. ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.112.4.e325
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVE:Sleep-disordered breathing (SDB) is associated with insulin resistance and dyslipidemia in adults and in obese children. However, the prevalence of such metabolic abnormalities among snoring children is unknown. This study was done to prospectively assess the relative contribution of SDB and obesity to metabo...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-2527
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:To establish the diagnostic profile in children who present with cyclic vomiting. METHODS:We studied 225 children < 18 years of age who presented to our pediatric gastroenterology service from 1986 to 1997 with at least three discrete episodes of vomiting between which they were well. To determine the diagno...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.102.3.583
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVES:To estimate the association between birth weight and hearing impairment among Norwegians born between 1967 and 1993, taking other pregnancy-related conditions into consideration. METHODS:A cohort study was conducted of all Norwegian live births from 1967 to 1993 (n = 1 548 429) linking information of the Me...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.110.3.e30
更新日期:2002-09-01 00:00:00
abstract::Adult patients with long-standing hypertension have been reported to experience an impairment in renal function when treatment with potent vasodilating agents is initiated. To document that this sequence may occur in children as well, we report the case of a 4-year-old boy with renal disease in whom reduction of blood...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1981-06-01 00:00:00
abstract:OBJECTIVE:To examine whether parenting styles or practices were associated with children's television (TV) viewing. METHODS:A total of 431 parent-child dyads (10- to 11-year-old children) from Bristol, United Kingdom, were included. Child and parent TV viewing were self-reported and categorized as <2, 2 to 4, or >4 ho...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-3664
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVES:To describe the prevalence of postdischarge outpatient rehabilitation among Medicaid-insured children hospitalized with a traumatic brain injury (TBI) and to identify factors associated with receipt of services. METHODS:Retrospective cohort of children <21 years, hospitalized for a TBI between 2007 and 2012...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2015-3500
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:It remains unclear if fatal brain injuries in young children are characterized by immediate rapid deterioration or can present after an initial period of lucidity. This issue has legal implications in child abuse, for which understanding the clinical course affects perpetrator identification. OBJECTIVE:To d...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-2671
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Although the Centers for Disease Control (CDC) growth charts are widely used in studies of childhood obesity, BMI z scores are known to be inaccurate at values greater than the 97th percentile. METHODS:We used longitudinal data from 6994 children in the Bogalusa Heart Study who were examined multiple times ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-1072
更新日期:2017-09-01 00:00:00
abstract::The frequency of otitis media with effusion (serous otitis media, secretory otitis media) detected after conventional antibiotic treatment of acute otitis media is approximately 50%. The relationship between pharmacologic compliance and the frequency of otitis media with effusion was studied. A Micrococcus lutea bioin...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1981-11-01 00:00:00
abstract:OBJECTIVES:The Hawaii Child Asthma Research to Elevate Standards (CARES) Program implemented an emergency department (ED)-based education and management program to facilitate National Asthma Education and Prevention Program (NAEPP) guideline understanding among asthmatic children and their families, ED staff, and healt...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2005-2000L
更新日期:2006-04-01 00:00:00
abstract::A prospective study was performed to determine whether excess morbidity occurred in critically ill and injured pediatric patients during interhospital transport compared with morbidity in a control group. Control observations were made during the first 2 hours of pediatric intensive care unit (PICU) care of patients e...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
abstract:OBJECTIVE:Kernicterus is a rare but devastating condition. The prevention of bilirubin-induced brain injury is based on the detection of infants at risk for developing severe hyperbilirubinemia. In an 18-hospital health system, Intermountain Health Care (IHC), we initiated a program of predischarge bilirubin screening ...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2005-1338
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:There is a common belief that children are not getting enough sleep and that children's total sleep time has been declining. Over the century, many authors have proposed sleep recommendations. The aim of this study was to describe historical trends in recommended and actual sleep durations for ...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2011-2039
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVES:Recent analyses assessing the impact of the conjugate pneumococcal vaccine on the care of febrile children do not reflect the role parental preferences play in physicians' decisions. The objective of this study was to identify the management strategy that would best suit parents, on the basis of their values...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-1865
更新日期:2006-04-01 00:00:00
abstract::Diabetic retinopathy (DR) is the leading cause of blindness in young adults in the United States. Early identification and treatment of DR can decrease the risk of vision loss in affected patients. This clinical report reviews the risk factors for the development of DR and screening guidance for pediatric patients wit...
journal_title:Pediatrics
pub_type: 杂志文章,实务指引
doi:10.1542/peds.2005-0875
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:To determine correlates of sedentary behaviors in adolescents through the examination of psychosocial and environmental variables. METHOD:The study used a cross-sectional design to evaluate an ethnically diverse clinic-based sample of 878 adolescents who were 11 to 15 years old. Bivariate and multivariate an...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-1814
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:Our goal was to assess the impact of "Baby-Friendly" hospital practices and other maternity-care practices experienced by mothers on breastfeeding duration. METHODS:This analysis of the Infant Feeding Practices Study II focused on mothers who initiated breastfeeding and intended prenatally to breastfeed for ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-1315e
更新日期:2008-10-01 00:00:00
abstract::We present a 6-week-old male infant with persistent hyperbilirubinemia, hypertriglyceridemia, elevated creatine kinase levels, and transaminitis since the second week of life. When he developed hyperkalemia, clinical suspicion was raised for adrenal insufficiency despite hemodynamic stability. A full endocrine workup ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2016-1479
更新日期:2017-07-01 00:00:00
abstract::Two different tetravalent polysaccharide vaccines against group A, C, Y, and W135 meningococci were given to 118 infants aged 6 to 23 months; the same vaccines were administered in a second dose 12 months later to those infants aged 6 to 11 months at first vaccination. Forty of the infants received vaccine containing ...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1985-07-01 00:00:00
abstract::A rare complication of infection with the Epstein-Barr virus is the development of hemophagocytic lymphohistiocytosis. Although most cases of Epstein-Barr virus-induced hemophagocytic lymphohistiocytosis develop in immunocompetent individuals, the rare immunodeficiency X-linked lymphoproliferative disease is often unm...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-1534
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The Value in Inpatient Pediatrics Network sponsored the Improving Care in Community Acquired Pneumonia collaborative with the goal of increasing evidence-based management of children hospitalized with community acquired pneumonia (CAP). Project aims included: increasing use of narrow-spectrum ...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2016-1411
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of vitamin D3 supplementation on the incidence and risk for first and recurrent diarrheal illnesses among children in Kabul, Afghanistan. METHODS:This double-blind placebo-controlled trial randomized 3046 high-risk 1- to 11-month-old infants to receive 6 quarterly doses of oral vita...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2012-3986
更新日期:2013-10-01 00:00:00