Prolonged use of large intravenous steroid pulses in the rheumatic diseases of children.

Abstract:

:Nineteen children with rheumatic diseases refractory to standard treatment were given repeated large "pulses" of corticosteroid therapy. The pulses consisted of four repeated doses of 500 mg of hydrocortisone given intravenously over 20 to 30 minutes at six-hour intervals or of single intravenous injections of 30 mg/kg of methylprednisolone. All patients had temporary relief of signs or symptoms of inflammation. Complications were mild and only one child was removed from therapy because of a complication. Two children were judged to be treatment failures. Five patients have been weaned from all steroid treatment, and eight have required continued pulses at one- or two-week intervals as outpatients to maintain control. All of these have been able to reduce oral prednisone doses. Effects of the two forms of pulse appear similar. However, two children responded to the series of injections of hydrocortisone but not to single doses of methylprednisolone. Pulses have been given for periods up to three years without evident toxicity. Further work to define doses, schedules, and optimal drug is needed since this approach to steroid use appears effective and relatively nontoxic.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Miller JJ 3rd

subject

Has Abstract

pub_date

1980-05-01 00:00:00

pages

989-94

issue

5

eissn

0031-4005

issn

1098-4275

journal_volume

65

pub_type

杂志文章
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    authors: Kato S,Furuyama N,Ozawa K,Ohnuma K,Iinuma K

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    authors: Morgan TM,Schlegel C,Edwards KM,Welch-Burke T,Zhu Y,Sparks R,Summar M,Urea Cycle Disorders Consortium.

    更新日期:2011-05-01 00:00:00

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    abstract::To evaluate the long-term effects of slow-release formulations of theophylline and terbutaline on pulmonary function, clinical symptoms, and side effects, 24 children with stable and moderately severe perennial asthma participated in a prospective double-blind cross-over study. The patients and the treatments were ran...

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    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Chow OK,Fung KP

    更新日期:1989-07-01 00:00:00

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    authors: Donoghue AJ,Nadkarni VM,Elliott M,Durbin D,American Heart Assocation National Registry of Cardiopulmonary Resuscitation Investigators.

    更新日期:2006-09-01 00:00:00

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    authors: Tieder JS,Hall M,Auger KA,Hain PD,Jerardi KE,Myers AL,Rahman SS,Williams DJ,Shah SS

    更新日期:2011-08-01 00:00:00

  • Predictors of phrase and fluent speech in children with autism and severe language delay.

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    更新日期:2013-04-01 00:00:00

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    pub_type: 杂志文章

    doi:

    authors: Ungerer JA,Horgan B,Chaitow J,Champion GD

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  • Service Use Classes Among School-aged Children From the Autism Treatment Network Registry.

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    pub_type: 杂志文章,多中心研究

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    更新日期:2020-04-01 00:00:00

  • Pediatricians and general practitioners: a comparison of the management of children with febrile illness.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Leduc DG,Pless IB

    更新日期:1982-10-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1542/peds.2012-2087

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-0929

    authors: McMillan HJ,Gregas M,Darras BT,Kang PB

    更新日期:2011-01-01 00:00:00

  • Pediatric autonomic disorders.

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    pub_type: 杂志文章,评审

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    journal_title:Pediatrics

    pub_type: 杂志文章

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    doi:10.1542/peds.2017-2238

    authors: Bester J,Sabatello M,van Karnebeek CDM,Lantos JD

    更新日期:2018-04-01 00:00:00

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-1146

    authors: Khoshoo V,Edell D,Thompson A,Rubin M

    更新日期:2007-11-01 00:00:00

  • Long-term subcutaneous protein C replacement in neonatal severe protein C deficiency.

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    journal_title:Pediatrics

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  • Hypocalcemic coma following two pediatric phosphate enemas.

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    journal_title:Pediatrics

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    authors: Sotos JF,Cutler EA,Finkel MA,Doody D

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    更新日期:2013-04-01 00:00:00

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    pub_type: 杂志文章,评审

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    更新日期:2007-11-01 00:00:00

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    authors: Greydanus DE,McAnarney ER

    更新日期:1980-01-01 00:00:00