Abstract:
:Increased expression of cathelicidin antimicrobial peptide (CAMP) is related to the pathogenesis of rosacea. CAMP plays a crucial role in antimicrobial defences, such as the killing of mycobacteria. CAMP gene expression is regulated by vitamin D-dependent (VDR) and vitamin D-independent (C/EBPα) transcription factors. VDR-dependent CAMP expression is sufficient during the summer months in Nordic countries, but insufficient during Nordic winters, due to low ultraviolet (UV) levels. Historically, the Celts may have overcome this geographical disadvantage of deficient CAMP production during the winter through an as-yet undefined acquired mutation that activates the alternative vitamin D-independent CAMP promoter C/EBPα. C/EBPα is the downstream transcription factor of Toll-like receptor (TLR)-mediated innate immune reactions and endoplasmic reticulum (ER) stress responses. At the molecular level, all clinical trigger factors for rosacea can be regarded as ER stressors. A mutation-based upregulation of ER stress responsiveness in rosacea may thus explain patients' reduced threshold for ER stressors. It is notable that ER stress upregulates the potent lipid-mediator sphingosine-1-phosphate (S1P), which explains multiple pathological aberrations observed in rosacea skin. Enhanced ER stress/S1P signalling in rosacea appears to compensate for insufficient VDR-dependent CAMP expression, maintaining adequate CAMP levels during UV-deficient winter to combat life-threatening microbial infections, such as lupus vulgaris. Therefore, rosacea should not be considered as a disadvantage, but as evolution's blessing of the Celts which improved their survival. The concept presented here also explains the mechanism of Finsen's UV treatment of lupus vulgaris by UV- and ER stress-mediated upregulation of CAMP expression. Rosacea could therefore be described as the Celts' "inborn Finsen lamp".
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Melnik BCdoi
10.2340/00015555-2220subject
Has Abstractpub_date
2016-02-01 00:00:00pages
147-56issue
2eissn
0001-5555issn
1651-2057journal_volume
96pub_type
杂志文章,评审abstract::is missing (Short communication). ...
journal_title:Acta dermato-venereologica
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abstract::Hypopigmented macules are frequently observed in the photodamaged skin of elderly people. We undertook to study and treat 2 types of hypomelanosis of photoaged skin. These lesions were: 1) idiopathic guttate hypomelanosis; and 2) macular hypomelanosis. Comparative studies included: 1) high-resolution photography using...
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abstract::Pruritus is exacerbated at night in many systemic and dermatological diseases, resulting in reports of significantly diminished quality of life and sleep disturbances. At present, the underlying mechanisms responsible for night-time itching are not well understood. Nocturnal pruritus may be related to the circadian rh...
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abstract::The lysosomal enzyme beta-hexosaminidase and the melanocyte specific enzyme tyrosinase were examined in human melanoma cell cultures. The beta-hexosaminidase activity of the medium was approximately 40% of the total cellular activity after 24 h, while after 48 h the activity in the medium was twice that of the cells. ...
journal_title:Acta dermato-venereologica
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abstract::With fluorescence-histochemical methods (FIF method) pigment-producing cells were investigated in benign and malignant skin lesions. Here, pigment cells appear predominantly dendritic, whilst they are separated from each other by keratinocytes, cells of hair follicles, or cells of sebaceous glands. In lentigo maligna ...
journal_title:Acta dermato-venereologica
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abstract::Experimental infections with Trichophyton mentagrophytes and Trichophyton rubrum were performed on human hair in vitro and studied by conventional light microscopy, scanning (SEM) and transmission (TEM) electron microscopy. The penetrations visible by light microscopy in hair infected with T. mentagrophytes appeared a...
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更新日期:1985-01-01 00:00:00
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更新日期:1986-01-01 00:00:00
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journal_title:Acta dermato-venereologica
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
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更新日期:1978-01-01 00:00:00
abstract::We took biopsies from similar sites on the scalps of normal controls, normal looking and hair loss areas of patients with alopecia areata. The specimens were sectioned serially and horizontally. We measured morphological parameters, such as the diameter of the hair shaft, the thickness of the inner root sheath, the di...
journal_title:Acta dermato-venereologica
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journal_title:Acta dermato-venereologica
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
abstract::The effect of UV-light on Pityrosporum yeasts (P.) was studied: P. yeasts cultured from the skin were spread on Dixon plates and irradiated with different UVB-and UVA-light dosages and read after three days, controls were not irradiated. Also P. yeasts, immediately after irradiation, were isolated from the plates and ...
journal_title:Acta dermato-venereologica
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doi:102340/00015555706971
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pub_type: 杂志文章,多中心研究
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doi:
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journal_title:Acta dermato-venereologica
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1983-01-01 00:00:00
abstract::We describe a case of gingival hyperplasia in a 36-year-old renal transplantation recipient treated with nifedipine for severe arterial hypertension. The appearance of the gingival disorder was probably related to nifedipine intake. Histologically, in addition to the findings of acanthosis, papillomatosis and connecti...
journal_title:Acta dermato-venereologica
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更新日期:1985-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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