Abstract:
:This study obtained information on the serotypes and molecular typing characteristics of Streptococcus pneumoniae strains causing invasive diseases in Turkey. Sixty-eight S. pneumoniae isolates causing invasive pneumococcal diseases were collected from different regions of Turkey from 2009 to 2011. The isolates were characterized by performing multilocus sequence typing (MLST), pulsed-field gel electrophoresis (PFGE), and capsular serotyping, and 25 different serotypes were identified. Serotypes 19F, 23F, 1, 14, and 7F were common and accounted for 52.9% of all the serotypes. In addition, 54 different PFGE profiles (pulsotypes) were observed. Twenty-three of the 68 (33.8%) isolates were clustered into 9 pulsotypes. MLST analysis yielded 36 sequence types, of which 12 (33.3%) were novel. A comparison of results with the global pneumococcal MLST database by performing eBURST analysis showed that our strains belonged to 20 different clonal complexes and 5 singletons. In addition, we identified 4 new alleles: 2 gdh, 1 xpt, and 1 ddl. Thus, the results of this study highlighted a high level of diversity among pneumococcal isolates. In addition, the study identified a case of possible capsular switching.
journal_name
Jpn J Infect Disjournal_title
Japanese journal of infectious diseasesauthors
Guldemir D,Acar S,Otgun SN,Unaldi O,Gozalan A,Ertek M,Durmaz R,Invasive Pneumococcal Diseases Study Group.doi
10.7883/yoken.JJID.2015.062subject
Has Abstractpub_date
2016-05-20 00:00:00pages
207-12issue
3eissn
1344-6304issn
1884-2836journal_volume
69pub_type
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