当前位置： SCI文献检索 > JAPANESE JOURNAL OF INFECTIOUS DISEASES期刊下所有文献 > Histopathological evaluation of the efficacy of antifungals for experimental Trichosporon bloodstream infection.

Histopathological evaluation of the efficacy of antifungals for experimental Trichosporon bloodstream infection.

Abstract：

:The efficacy of polyene macrolides to treat experimental Trichosporon bloodstream infection was evaluated by histopathological examination and viable cell counts in the kidneys of infected mice. Viable cell counts on the 5th day after infection confirmed that liposomal amphotericin B (L-AMB) is a more effective treatment than fluconazole (FLC) for mice infected with an azole-resistant strain of Trichosporon. Histological examination revealed that the administration of L-AMB induced a transformation from acute purulent inflammation caused by both azole-susceptible and -resistant strain infections to a chronic and subsiding form, whereas FLC failed to convert the acute inflammation induced by the azole-resistant strain to a subsiding form. Our results demonstrate that polyene macrolides can be used as an alternative therapy for infection of azole-resistant strains of Trichosporon and that histopathological evaluation is useful for elucidating the pathophysiology of an experimental Trichosporon infection.

journal_name

Jpn J Infect Dis

journal_title

Japanese journal of infectious diseases

authors

Sasai D,Okubo Y,Ishiwatari T,Sugita T,Kaneko T,Murayama SY,Shimamura T,Shinozaki M,Hasegawa C,Mitsuda A,Tochigi N,Wakayama M,Nemoto T,Shibuya K

doi

10.7883/yoken.66.133

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

133-9

issue

2

eissn

1344-6304

issn

1884-2836

pii

DN/JST.JSTAGE/yoken/66.133

journal_volume

66

pub_type

杂志文章

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