Abstract:
:We investigated the relationship of infection with hepatitis B virus (HBV) and hepatitis C virus (HCV) to p53 mutation in hepatocellular carcinomas (HCC) from six countries, including Japan, China, Korea, Vietnam, Spain, and the Unites States. For this purpose, we used formalin-fixed, paraffin-embedded liver tissues obtained from 449 patients with HCC to detect the viral and p53 genes by polymerase chain reaction (PCR). HBV was the most prevalent in Korea (69.1%), China (66.1%), Vietnam (60.5%), and Spain (38.6%). In contrast, HCV was the most prevalent in Japan (59.8%) and in the United States (41.5%). Type C of HBV was the most common genotype (78.6%) encountered in HCC in these countries. Importantly, among 125 intrahepatic HBV DNA-positive patients, 44 (35.2%) were serologically negative for HBsAg (occult hepatitis B). Based on PCR, immunohistochemical, serological, and clinical findings, 4.8% of HCC patients were diagnosed with non-B, non-C. A point mutation at exon 7 of p53 was detected in 20 of the 239 HCC samples examined, including those from 9 Chinese, 5 American, 2 Japanese, 2 Korean, and 2 Spanish patients, respectively. Interestingly, a point mutation with an amino acid substitution at codon 251 (Ile-->Asn) was detected frequently in 11 of 20 (55%) cases. A specific mutation induced by Aflatoxin B1 at codon 249 was seen in two patients, both Chinese. Our results suggest that genotype C of HBV may play an important role in hepatocarcinogenesis in different geographic regions, and that in situ detection of HBV genomes could be important for clarifying the agent(s) of unknown etiology related to HCC.
journal_name
Jpn J Infect Disjournal_title
Japanese journal of infectious diseasesauthors
Ding X,Park YN,Taltavull TC,Thung SN,Jin X,Jin Y,Trung NS,Edamoto Y,Sata T,Abe Ksubject
Has Abstractpub_date
2003-02-01 00:00:00pages
12-8issue
1eissn
1344-6304issn
1884-2836journal_volume
56pub_type
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journal_title:Japanese journal of infectious diseases
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journal_title:Japanese journal of infectious diseases
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journal_title:Japanese journal of infectious diseases
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doi:
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journal_title:Japanese journal of infectious diseases
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更新日期:2004-06-01 00:00:00
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journal_title:Japanese journal of infectious diseases
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更新日期:2008-11-01 00:00:00
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journal_title:Japanese journal of infectious diseases
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更新日期:2003-10-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:
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