Abstract:
:Curtailing the observation of mice challenged with tetanus toxin in potency test of tetanus vaccine would reduce the agony of mice from spastic paralysis. From the viewpoint of animal welfare, we investigated the feasibility this measure. The potencies of 85 lots of vaccine obtained on the 4th day after challenge were compared with those obtained on the seventh day. No significant difference was found (P = 0.05), indicating that the observation period could be curtailed from 7 days to 4 days without impairing the assessment of the vaccine's potency.
journal_name
Jpn J Infect Disjournal_title
Japanese journal of infectious diseasesauthors
Fukuda T,Iwaki M,Komiya T,Arakawa Y,Takahashi Msubject
Has Abstractpub_date
2004-12-01 00:00:00pages
257-9issue
6eissn
1344-6304issn
1884-2836journal_volume
57pub_type
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