Attempt to curtail the observation period of mice in the tetanus vaccine potency tests.

Abstract:

:Curtailing the observation of mice challenged with tetanus toxin in potency test of tetanus vaccine would reduce the agony of mice from spastic paralysis. From the viewpoint of animal welfare, we investigated the feasibility this measure. The potencies of 85 lots of vaccine obtained on the 4th day after challenge were compared with those obtained on the seventh day. No significant difference was found (P = 0.05), indicating that the observation period could be curtailed from 7 days to 4 days without impairing the assessment of the vaccine's potency.

journal_name

Jpn J Infect Dis

authors

Fukuda T,Iwaki M,Komiya T,Arakawa Y,Takahashi M

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

257-9

issue

6

eissn

1344-6304

issn

1884-2836

journal_volume

57

pub_type

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