Abstract:
:Rapid and accurate diagnosis of infectious diseases, including mycobacterial disease such as tuberculosis (TB) and diseases due to nontuberculous mycobacteria (NTM), is a very important element of global health. The gold standard in diagnosis of mycobacterial diseases remains clinical examination, combined with direct microscopic examination of sputum and culture of bacteria. Culture of slowly growing mycobacteria, including Mycobacterium tuberculosis and NTM (such as M. avium complex: MAC), can take up to 4 to 6 weeks, and in 10-20% of cases the bacillus is not successfully cultivated. Diagnosis of MAC pulmonary disease (MAC-PD) is complicated and time-consuming (usually at least 1 month). I have characterized the nature of MAC antigens and immune responses from the aspect of basic mycobacteriology, and then translated to clinical science. My multicenter study in Japan has demonstrated the usefulness of a serodiagnostic test to determine serum IgA antibodies against mycobacterial glycopeptidolipid (GPL) core antigen for diagnosing MAC-PD within a few hours. To validate in a larger number of patients, at diverse geographic locations, and among other races, the test was also assessed the usefulness internationally in the United States and Taiwan. In this review, I discuss development of serodiagnosis of MAC-PD by translational research and international collaboration study.
journal_name
Jpn J Infect Disjournal_title
Japanese journal of infectious diseasesauthors
Kobayashi Kdoi
10.7883/yoken.67.329subject
Has Abstractpub_date
2014-01-01 00:00:00pages
329-32issue
5eissn
1344-6304issn
1884-2836pii
DN/JST.JSTAGE/yoken/67.329journal_volume
67pub_type
杂志文章,评审abstract::Chryseobacterium meningosepticum is an uncommon pathogen causing adult bacterial meningitis. Herein, we report the case history of one 21-year-old woman with this uncommon central nervous system infection. A diagnosis of adult C. meningosepticum meningitis can only be confirmed by a positive cerebrospinal fluid (CSF) ...
journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章,评审
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:10.7883/yoken.JJID.2015.626
更新日期:2017-01-24 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:10.7883/yoken.JJID.2014.235
更新日期:2015-01-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:10.7883/yoken.JJID.2019.056
更新日期:2020-01-23 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:10.7883/yoken.66.341
更新日期:2013-01-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:10.7883/yoken.66.449
更新日期:2013-01-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:
更新日期:2009-07-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:
更新日期:2001-08-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:
更新日期:2003-04-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:10.7883/yoken.JJID.2016.209
更新日期:2017-03-24 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:10.7883/yoken.JJID.2016.210
更新日期:2017-05-24 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:
更新日期:2008-05-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章,评审
doi:
更新日期:2004-10-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:
更新日期:2007-02-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章,评审
doi:
更新日期:2012-01-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:
更新日期:2006-08-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:
更新日期:2010-07-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:
更新日期:2006-08-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:
更新日期:2007-11-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:10.7883/yoken.65.383
更新日期:2012-01-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:10.7883/yoken.67.258
更新日期:2014-01-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 历史文章,杂志文章,评审
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更新日期:2017-01-24 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:10.7883/yoken.65.295
更新日期:2012-07-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:10.7883/yoken.JJID.2020.194
更新日期:2020-11-24 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:10.7883/yoken.66.133
更新日期:2013-01-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
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更新日期:2017-01-24 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:
更新日期:2005-04-01 00:00:00