Abstract:
:Diabetes mellitus and diarrhea are becoming increasingly burdensome worldwide, particularly in developing countries such as India. Diabetic patients are susceptible to infection with pathogenic bacteria, particularly those causing invasive enteric infections. In this study, we observed changes in the pathophysiological features of mice with streptozotocin-induced hyperglycemia. In our experiments, both hyperglycemic and control mice were infected with pathogenic enteric bacteria-non-typhoidal Salmonella, Shigella flexneri, or Vibrio parahaemolyticus. Morbidity, mortality, and bacterial load were all higher in the diabetic mice than in the control mice, and the phagocytic and bactericidal activities of peritoneal macrophages isolated from hyperglycemic mice were lower than they were in the controls. We hypothesize that hyperglycemia leads to a downregulation of the innate immune response, which in turn increases vulnerability to enteric bacterial infection.
journal_name
Jpn J Infect Disjournal_title
Japanese journal of infectious diseasesauthors
Koley H,Ghosh P,Sinha R,Mitra S,Mukherjee P,Howlader DR,Chaki C,Nag Ddoi
10.7883/yoken.JJID.2015.418subject
Has Abstractpub_date
2017-01-24 00:00:00pages
111-114issue
1eissn
1344-6304issn
1884-2836journal_volume
70pub_type
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