当前位置： SCI文献检索 > JAPANESE JOURNAL OF INFECTIOUS DISEASES期刊下所有文献 > Safety and Immunogenicity of the Quadrivalent HPV Vaccine in Japanese Boys: a Phase 3, Open-Label Study.

Safety and Immunogenicity of the Quadrivalent HPV Vaccine in Japanese Boys: a Phase 3, Open-Label Study.

Abstract：

:Human papillomavirus (HPV)-associated disease is common among men with HPV infection. A quadrivalent HPV (qHPV) vaccine has demonstrated 85.9% efficacy against HPV6/11/16/18-related, persistent (≥ 6 month) infection in a study of Japanese men aged 16-26 years old. Here, we report the results of an open-label study of the immunogenicity and tolerability of the qHPV vaccine (NCT02576054), conducted to bridge findings from Japanese men to Japanese boys aged 9-15 years old. A total of 100 boys completed a three-vaccination regimen (Day 1, and Months 2 and 6), and 99 boys were included in the primary analysis population. The rate of seroconversion at one month after vaccine Dose 3 (Month 7) was high for each type of HPV (anti-HPV6/11/16/18 seroconversion rates [95% CI]: 94.9% [85.5%, 98.3%], 99.0% [94.4%, 100.0%], 99.0% [94.5%, 100.0%], and 99.0% [94.4%, 100.0%], respectively). Moreover, anti-HPV6/11/16/18 geometric mean titers were 482.9 mMU/mL, 1052.8 mMU/mL, 3878.3 mMU/mL, and 1114.5 mMU/mL, respectively. Immune responses to the qHPV vaccine were non-inferior among Japanese boys included in the current study and compared with young Japanese men from a separate study. Injection-site reactions were the most common adverse events, and administration of the vaccine was well tolerated in Japanese boys.

journal_name

Jpn J Infect Dis

journal_title

Japanese journal of infectious diseases

authors

Murata S,Takeuchi Y,Yamanaka K,Hayakawa J,Yoshida M,Yokokawa R,Wakana A,Sawata M,Tanaka Y

doi

10.7883/yoken.JJID.2018.448

subject

Has Abstract

pub_date

2019-09-19 00:00:00

pages

299-305

issue

5

eissn

1344-6304

issn

1884-2836

journal_volume

72

pub_type

杂志文章

相关文献

JAPANESE JOURNAL OF INFECTIOUS DISEASES文献大全
  • Leprosy as a challenge to science on the ability to decode its enigma. A hypothesis on how to respond.

    abstract：:In world leprosy nowadays, a favorable epidemiologic trend has been provided due to the best effort of the worldwide campaign with chemotherapy providing a bright but one-sided look at the future. However, the numbers of new patients are still higher than those under chemotherapy, leaving a concern over the remaining ...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章,评审

    doi：

    authors： Matsuo E

    更新日期：2005-04-01 00:00:00

  • Difference in distribution of Chlamydia trachomatis genotypes among different provinces: a pilot study from four provinces in China.

    abstract：:The objective of this study was to assess the distribution of Chlamydia trachomatis genovars in male sexually transmitted disease (STD) clinic patients from 1 province in eastern China (Jiangsu) and 3 provinces in southern China (Guangdong, Guangxi, and Hainan). Urine specimens (n = 140) were collected from 46 public ...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：10.7883/yoken.66.69

    authors： Han Y,Yin YP,Shi MQ,Zhong MY,Chen SC,Xang Z,Jiang N,Chen XS

    更新日期：2013-01-01 00:00:00

  • A food-borne outbreak of gastroenteritis caused by different Salmonella serotypes in 2 universities in Xiamen, Fujian, China, in 2012.

    abstract：:We investigated a diarrhea outbreak in 2 universities to identify the etiological agent responsible, the source of infection, the mode of transmission, and the risk factors. A case-controlled study was conducted using case students and asymptomatic control students who were selected randomly and frequency-matched acco...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：10.7883/yoken.JJID.2014.235

    authors： Guo Z,Su Ch,Huang J,Niu J

    更新日期：2015-01-01 00:00:00

  • Comparison of the Predictive Performances of qSOFA, APACHE II, and SGS for Evaluation of the Disease Prognosis of CCHF Patients at the Emergency Department.

    abstract：:In this study, we compared the predictive performances of quick sequential organ failure assessment (qSOFA), the acute physiology and chronic health evaluation (APACHE II) scores, and the severity grading score (SGS) for evaluation of the disease prognosis of patients with Crimean-Congo hemorrhagic fever (CCHF) at the...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：10.7883/yoken.JJID.2019.507

    authors： Demirtas E,Bakir M,Buyuktuna SA,Oksuz C,Oz M,Cebecioglu K,Unlusavuran M

    更新日期：2020-09-24 00:00:00

  • International Comparison of Causative Bacteria and Antimicrobial Susceptibilities of Urinary Tract Infections between Kobe, Japan, and Surabaya, Indonesia.

    abstract：:Variation by country in urinary tract infection (UTI)-causative bacteria is partly due to the differences in the use of antibiotics. We compared their frequencies and antibiotic susceptibilities in the treatment of patients with UTI from 2 cities, Kobe, Japan, and Surabaya, Indonesia. We retrospectively analyzed 1,804...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：10.7883/yoken.JJID.2017.233

    authors： Kitagawa K,Shigemura K,Yamamichi F,Alimsardjono L,Rahardjo D,Kuntaman K,Shirakawa T,Fujisawa M

    更新日期：2018-01-23 00:00:00

  • The Rapid Induction of Carbapenem-Resistance in an Aeromonas dhakensis Blood Isolate.

    abstract：:Meropenem-susceptible and -resistant Aeromonas dhakensis isolates from blood cultures of a fatal case of septicemia were analyzed. The two isolates were homologous and gene expression of metallo-β-lactamase in the resistant strain was upregulated. Physicians should be aware of the possibility of the induction of carba...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：10.7883/yoken.JJID.2015.098

    authors： Murata M,Morinaga Y,Akamatsu N,Matsuda J,Uno N,Kosai K,Hasegawa H,Okada M,Moriuchi H,Yanagihara K

    更新日期：2016-09-21 00:00:00

  • The adverse events of influenza A (H1N1) vaccination and its risk factors in healthcare personnel in 18 military healthcare units in Korea.

    abstract：:In this study, we characterized adverse events related to influenza A (H1N1) vaccination and studied the factors that influence the occurrence of these events. A total of 4,302 personnel in 18 military healthcare units in Korea received 0.5 ml of inactivated H1N1 vaccine. The study questionnaires were answered by 3,93...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：

    authors： Hwang SM,Choe KW,Cho SH,Yoon SJ,Park DE,Kang JS,Kim MJ,Chun BC,Lee SM

    更新日期：2011-01-01 00:00:00

  • Multicenter Study of the Clinical Presentation of Staphylococcus lugdunensis Bacteremia in Japan.

    abstract：:Staphylococcus lugdunensis (SL) is a bacterium with a highly pathogenicity than most other coagulase-negative Staphylococcus spp. (CoNS). In Japan, data on this pathogen are sparse, and the current prevalence of SL bacteremia is unknown. Therefore, we investigated the prevalence of SL in blood culture specimens in a p...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章,多中心研究

    doi：10.7883/yoken.JJID.2016.130

    authors： Ainoda Y,Takeshita N,Hase R,Mikawa T,Hosokawa N,Kawamura I,Kurai H,Abe M,Kimura M,Araoka H,Fujita T,Totsuka K,Mezaki K,Sekiya N,Ohmagari N

    更新日期：2017-07-24 00:00:00

  • Prediction of Contact Residues in Anti-HIV Neutralizing Antibody by Deep Learning.

    abstract：:The monoclonal antibody 1C10 targets the V3 loop of HIV-1 and neutralizes a broad range of clade B viruses. However, the mode of interaction between 1C10 and the V3 loop remains unclear because crystallization of 1C10 and the V3 peptide was unsuccessful due to the flexible regions present in both 1C10 and the V3 pepti...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：10.7883/yoken.JJID.2019.496

    authors： Kaku Y,Kuwata T,Gorny MK,Matsushita S

    更新日期：2020-05-22 00:00:00

  • Early detection of systemic candidiasis in the whole blood of patients with hematologic malignancies.

    abstract：:Systemic candidiasis is a significant cause of morbidity and mortality in patients with hematologic disorders. The aim of this study was to determine the prevalence of systemic candidiasis and the efficiency of the polymerase chain reaction-enzyme-linked immunosorbent assay (PCR-ELIZA) method for the early detection o...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：

    authors： Badiee P,Kordbacheh P,Alborzi A,Zakernia M,Haddadi P

    更新日期：2009-01-01 00:00:00

  • Seroprevalence of a novel influenza A (H3N2) variant virus in the Japanese population.

    abstract：:Antibody distribution to a novel swine-origin influenza A (H3N2) variant virus among different age groups in Japan was determined by hemagglutination-inhibition assay. Japanese children in the age group 1-14 years were at a higher risk than those in older age groups. ...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：10.7883/yoken.66.549

    authors： Kishida N,Imai M,Xu H,Taya K,Fujisaki S,Takashita E,Tashiro M,Odagiri T

    更新日期：2013-01-01 00:00:00

  • The role of myeloperoxidase in the pathogenesis of coronary artery disease.

    abstract：:A growing body of evidence continues to emerge implicating the role of myeloperoxidase (MPO) and its oxidant products in the promotion of atherogenesis. A major mechanism by which MPO impacts the arterial wall is through its modification of net cellular cholesterol flux. MPO promotes lipid peroxidation and conversion ...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章,评审

    doi：

    authors： Nicholls SJ,Hazen SL

    更新日期：2004-10-01 00:00:00

  • Characterization of CTX-M-22 and TEM-141 Encoded by a single plasmid from a clinical isolate of Enterobacter cloacae in China.

    abstract：:We analyzed the resistance to expanded-spectrum cephalosporins of an Enterobacter cloacae clinical isolate, EC002, by transconjugation, isoelectric-focusing analysis, and cloning experiments. It produced two beta-lactamases with isoelectric point values of 5.4 and 8.7, corresponding to TEM-141, a novel variant of TEM-...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：

    authors： Liu G,Ling BD,Xie YE,Lin L,Zeng Y,Zhang X,Lei J

    更新日期：2007-09-01 00:00:00

  • Clinical and molecular characterization of hand-foot-and-mouth disease in Thailand, 2008-2009.

    abstract：:Hand-foot-and-mouth disease (HFMD) is caused by a group of enteroviruses, most commonly coxsackievirus A 16 (CA16) and enterovirus 71 (EV71). In general, the disease is mild and self-limited except in the case of EV71 infections, which may incur serious complications. This research focused on virus characterization of...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：

    authors： Chatproedprai S,Theanboonlers A,Korkong S,Thongmee C,Wananukul S,Poovorawan Y

    更新日期：2010-07-01 00:00:00

  • Factors Associated with Immunological Discordance in HIV-Infected Patients Receiving Antiretroviral Therapy with Complete Viral Suppression in a Resource-Limited Setting.

    abstract：:"Immunological discordance," i.e., immunological failure despite complete viral suppression in human immunodeficiency virus (HIV)-infected patients receiving antiretroviral therapy (ART), is associated with increased risk of AIDS or death. To evaluate risk factors for immunological discordance in a resource-limited se...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：10.7883/yoken.JJID.2014.062

    authors： Mingbunjerdsuk P,Asdamongkol N,Sungkanuparph S

    更新日期：2015-01-01 00:00:00

  • Immune reconstitution inflammatory syndrome among HIV/AIDS patients during highly active antiretroviral therapy in Addis Ababa, Ethiopia.

    abstract：:Suppression of viral replication is followed by increases in CD4+ lymphocytes, and this has been shown to result in decreased susceptibility to opportunists after initiation of highly active antiretroviral therapy (HAART). However, clinical aggravations after the initiation of HAART have been thought to be due to the ...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：

    authors： Huruy K,Mulu A,Mengistu G,Shewa-Amare A,Akalu A,Kassu A,Andargie G,Elias D,Torben W

    更新日期：2008-05-01 00:00:00

  • Relationship between MMP Expression and Virulence of Dengue Virus Type-2 in Infected Mosquito and Mammalian Cells.

    abstract：:Dengue virus infections are mostly asymptomatic but can produce a mild, self-limiting acute febrile illness, dengue fever, or a life threatening severe illness, dengue hemorrhagic fever. Dengue hemorrhagic fever is associated with increased vascular permeability partly as a result of elevated levels of matrix metallop...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：10.7883/yoken.JJID.2014.323

    authors： Leaungwutiwong P,Kelley JF,Sachair A,Jittmittraphap A,Luplertlop N

    更新日期：2016-01-01 00:00:00

  • Impact of population size on incidence of rubella and measles in comparison with that of other infectious diseases.

    abstract：:A strong dependency of rubella and measles epidemics on population size was confirmed by 2 types of plots: the cumulative frequency distribution of number of cases per prefecture and the slope of the log-log plots of number of cases per prefecture on the y-axis vs. prefecture population size on the x-axis. These param...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：10.7883/yoken.67.447

    authors： Yoshikura H

    更新日期：2014-01-01 00:00:00

  • Predictors of Hospitalization and Admission to Intensive Care Units of Influenza Patients in Serbia through Four Influenza Seasons from 2010/2011 to 2013/2014.

    abstract：:A retrospective analysis of the surveillance data on laboratory confirmed cases of influenza in 4 post pandemic seasons in Serbia was performed to evaluate predictors of hospitalization and admission to intensive care units (ICU). The specimens, including nasal and throat swabs were tested for influenza. Univariate an...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：10.7883/yoken.JJID.2016.210

    authors： Dimitrijević D,Ilić D,Rakić Adrović S,Šuljagić V,Pelemiš M,Stevanović G,Milinković M,Šipetić Grujićić S

    更新日期：2017-05-24 00:00:00

  • In vitro activity of linezolid against Mycobacterium tuberculosis strains isoalted from Western Turkey.

    abstract：:We investigated the linezolid susceptibility of Mycobacterium tuberculosis strains isolated from a tertiary care hospital in Izmir. A total of 67 M. tuberculosis strains (33 multidrug-resistant [MDR] and 34 non-MDR) were isolated and identified by the Tuberculosis Laboratory, Department of Microbiology and Clinical Mi...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：

    authors： Ermertcan S,Hosgor-Limoncu M,Erac B,Tasli H,Cavusoglu C,Bozkurt H

    更新日期：2009-09-01 00:00:00

  • A Safety and Immunogenicity Study of a Single Dose of a Meningococcal (Groups A, C, W, and Y) Polysaccharide Diphtheria Toxoid Conjugate Vaccine (MEN-ACWY-D) in Healthy Japanese Participants.

    abstract：:Meningococcal disease can cause significant disability and mortality. The quadrivalent meningococcal polysaccharide diphtheria toxoid conjugate vaccine (Men-ACWY-D) protects against invasive meningococcal disease caused by serogroups A, C, W, and Y. This phase III, open-label, single-arm, multicenter study evaluated t...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章,多中心研究

    doi：10.7883/yoken.JJID.2017.277

    authors： Fukushima S,Kikuchi H,Miyazu M,Hamada A,Ouchi K,Takagi H,Mihara H,Sasaki T,Oka H,Bosch-Castells V,Oster P

    更新日期：2018-11-22 00:00:00

  • Possible horizontal transmission of crimean-congo hemorrhagic Fever virus from a mother to her child.

    abstract：:The case of a child with Crimean-Congo hemorrhagic fever (CCHF) presumably infected with CCHF virus from her 27-year-old mother is described. The mother with CCHF was treated with ribavirin and did not present with any symptoms of obvious hemorrhage. The child developed fever on the 5th day after the mother's onset. T...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：

    authors： Saijo M,Tang Q,Shimayi B,Han L,Zhang Y,Asiguma M,Tianshu D,Maeda A,Kurane I,Morikawa S

    更新日期：2004-04-01 00:00:00

  • Two cases of sucrose-fermenting Vibrio vulnificus infection in which 16S rDNA sequencing was useful for diagnosis.

    abstract：:Vibrio vulnificus is a Gram-negative bacterium which is associated with severe infections in humans. We experienced two cases of sucrose-fermenting V. vulnificus infection. The causative agents in both cases were unidentifiable by conventional identification systems because of their unique characteristics, and sequenc...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：

    authors： Nagao M,Shimizu Y,Kawada Y,Baba H,Yamada K,Torii K,Ohta M

    更新日期：2006-04-01 00:00:00

  • Laboratory Evaluation of Rapid Antigen Detection Tests for More-Sensitive Detection of Respiratory Syncytial Virus Antigen.

    abstract：:We evaluated two currently available rapid antigen detection tests (RADTs) for Respiratory syncytial virus (RSV), Sofia® RSV FIA and BinaxNOW RSV Card (BinaxNOW). Between November 2017 and February 2018, 395 nasopharyngeal swabs were collected from children diagnosed with acute respiratory infections. The swabs were e...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：10.7883/yoken.JJID.2018.528

    authors： Sun Y,Deng J,Qian Y,Zhu R,Wang F,Tian R,De R,Zhao L

    更新日期：2019-11-21 00:00:00

  • Seasonal influenza surveillance using prescription data for anti-influenza medications.

    abstract：:Surveillance is critical for both early detection and a timely public health response to infectious diseases. Electronic information systems have been widely adopted by pharmacies in Japan. The aim of this study is to evaluate the feasibility of using prescription data for influenza surveillance in Japan to facilitate...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：

    authors： Yoshida M,Matsui T,Ohkusa Y,Kobayashi J,Ohyama T,Sugawara T,Yasui Y,Tachibana T,Okabe N

    更新日期：2009-05-01 00:00:00

  • Identification of a novel metallo-β-lactamase VIM-28 located within unusual arrangement of class 1 integron structure in Pseudomonas aeruginosa isolates from Egypt.

    abstract：:Two multidrug-resistant Pseudomonas aeruginosa strains harboring blaVIM were isolated from a hospital in Egypt and were indistinguishable by pulsed-field gel electrophoresis. Sequence analysis revealed a novel VIM β-lactamase, VIM-28. Additional sequencing of integron revealed that the blaVIM-28 gene cassette had an u...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：

    authors： El-Mahdy TS

    更新日期：2014-01-01 00:00:00

  • Virulence profile of diarrhoeagenic Escherichia coli from the Western region of Ghana.

    abstract：:Diarrhoeagenic Escherichia coli (DEC), an important agent of infectious diarrhoea, is constantly evolving, making it necessary for its periodic monitoring. Unfortunately, DEC genotypes in Ghana remain uncharacterised. We focused on characterising the molecular serotypes, virulence factors, multilocus sequence types, a...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：10.7883/yoken.JJID.2020.356

    authors： Prah I,Ayibieke A,Huong NTT,Iguchi A,Mahazu S,Sato W,Hayashi T,Yamaoka S,Suzuki T,Iwanaga S,Ablordey A,Saito R

    更新日期：2020-08-31 00:00:00

  • Circulating Genotypes of Dengue-1 Virus in South West India, 2014-2015.

    abstract：:Dengue is the most prevalent arboviral disease affecting humans, with tropical and subtropical regions having the highest risk of dengue virus infections. The clinical symptoms often range from mild fever to fever with hemorrhagic manifestations and shock. Since 2010, India has been witnessing a marked increase in the...

    journal_title：Japanese journal of infectious diseases

    pub_type： 历史文章,杂志文章

    doi：10.7883/yoken.JJID.2017.087

    authors： Pooja S,Sabeena S,Revti B,Sanjay R,Anjali A,Rajendra K,Aswathyraj S,Giselle D,Hindol M,Arunkumar G

    更新日期：2017-11-22 00:00:00

  • Fluctuations in Antibody Titers against Enterovirus D68 in Pediatric Sera Collected in a Community before, during, and after a Possible Outbreak.

    abstract：:We previously reported a hospital-based epidemiological study on enterovirus (EV)-D68 infection among children during the autumn of 2015, which indirectly inferred an outbreak in Sendai, Japan. In this study, stocked sera of children (aged 0-6 years; without symptoms of infectious diseases) in the Sendai community col...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：10.7883/yoken.JJID.2019.056

    authors： Kadji FMN,Nishimura H,Okamoto M,Sato K,Ohmiya S,Ito H,Suzuki A,Nagai Y,Oshitani H

    更新日期：2020-01-23 00:00:00

  • Chlamydial infections in term and preterm neonates.

    abstract：:The aim of this study was to evaluate the incidence and morbidities of Chlamydia trachomatis infections in newborn infants. Tissue culture and direct immunofluorescence (DIF) tests were used to detect the presence of nasopharyngeal C. trachomatis infection in 35 preterm and 21 healthy term neonates. All infants wer...

    journal_title：Japanese journal of infectious diseases

    pub_type： 杂志文章

    doi：

    authors： Bekler C,Kultursay N,Ozacar T,Sayiner A,Yalaz M,Akisu M

    更新日期：2012-01-01 00:00:00