Noncirrhotic portal hypertension associated with didanosine: a case report and literature review.

Abstract:

:Noncirrhotic portal hypertension (NCPH) has recently been reported as a liver complication in human immunodeficiency virus (HIV)-infected patients and has been found to be associated with exposure to didanosine. Here, we describe the case of an HIV-infected patient with portal hypertension who initially presented with massive ascites and portal vein thrombosis. The patient's HIV-1 infection was well-controlled with highly active antiretroviral therapy (lamivudine/didanosine plus nevirapine) for 3 years since its diagnosis in 2007. He had no history of alcoholism, drug abuse, or liver diseases. An extensive work-up for other possible causes of liver disease was performed, but the results were inconclusive. In addition to reporting this case, we have reviewed the literature on didanosine-related NCPH and analyzed the findings of 61 similar previously reported cases.

journal_name

Jpn J Infect Dis

authors

Chang HM,Tsai HC,Lee SS,Wann SR,Chen YS

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

61-5

issue

1

eissn

1344-6304

issn

1884-2836

journal_volume

65

pub_type

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