Abstract:
:Hepatitis B virus (HBV) surface antigen mutations may lead to immune escape and eventually cause failure of immunization. In this report, we identified immune escape variants in immunized babies born to hepatitis B surface antigen (HBsAg) carrier mothers. A total of 68 babies were followed up for 2 years after the full course of vaccination; 2.9% (2/68) of babies were found to be infected with the variant HBV in spite of preexisting antibody to surface antigen (anti-HBs) at 24 months post immunization. Both infants were positive for HBV-DNA; sequencing results of the "a" determinant region of the surface gene revealed that both babies had point mutations at a different nucleotide position resulting in various amino acid substitutions. In addition, an intriguing variant having an addition-deletion mutation was observed in one of the babies. This is the first report to show the addition-deletion variant of HBV in India. However, the immunological significance of the above HBV variants needs to be further elucidated.
journal_name
Jpn J Infect Disjournal_title
Japanese journal of infectious diseasesauthors
Velu V,Saravanan S,Nandakumar S,Dhevahi E,Shankar EM,Murugavel KG,Kumarasamy T,Thyagarajan SPsubject
Has Abstractpub_date
2008-01-01 00:00:00pages
73-6issue
1eissn
1344-6304issn
1884-2836journal_volume
61pub_type
杂志文章abstract::This study aimed to determine the levels of the macrolides-lincosamides-streptogramins B (MLS(B)) resistance phenotype of Staphylococcus aureus and coagulase-negative staphylococci (CNS) isolates from clinical samples. A total of 521 strains of staphylococci, comprising 230 S. aureus and 291 CNS isolates from various ...
journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:
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journal_title:Japanese journal of infectious diseases
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
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journal_title:Japanese journal of infectious diseases
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pub_type: 杂志文章
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
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journal_title:Japanese journal of infectious diseases
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pub_type: 杂志文章
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:
更新日期:2005-06-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:10.7883/yoken.JJID.2015.626
更新日期:2017-01-24 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:10.7883/yoken.JJID.2014.321
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:10.7883/yoken.67.447
更新日期:2014-01-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:10.7883/yoken.JJID.2016.419
更新日期:2017-09-25 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:
更新日期:2005-02-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:10.7883/yoken.JJID.2015.224
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pub_type: 杂志文章
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:
更新日期:2003-10-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:10.7883/yoken.JJID.2020.589
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:
更新日期:2008-09-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 临床试验,杂志文章
doi:
更新日期:2011-01-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
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更新日期:2010-07-01 00:00:00
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journal_title:Japanese journal of infectious diseases
pub_type: 杂志文章
doi:
更新日期:2006-10-01 00:00:00