Genotyping of Human Papillomavirus in Cervical Squamous Intraepithelial Lesions in Mexican Women.

Abstract:

:Approximately 40 genotypes of the human papillomavirus (HPV) have been identified in cervical mucosa. In particular, HPV-16 and HPV-18 have been associated with cervical neoplasia. Squamous intraepithelial lesions (SILs) are precursors of cervical cancer. This study aimed to identify the HPV by genotype in SILs using a linear array genotyping test in a population in Mexico. We performed a cross-sectional study of 129 female patients with or without SILs, as determined by colposcopy, who completed a risk factor questionnaire. Cervical swab samples were obtained and genotyped using a Linear Array HPV Genotyping assay. Forty-nine (37.98%) samples were positive for HPV, and 24 genotypes were identified among these samples. The most common genotype was HPV-16. Twelve genotypes were found in both high- and low-grade SILs (HPV-6, 16, 31, 39, 51, 52, 53, 58, 59, 61, 67, and 84), of which seven were high-risk SILs (HPV-16, 31, 39, 51, 52, 58, and 59). Among the populations studied, the most frequent genotype was HPV-16, multiple infections were found, and four patients without injury tested positive for HPV.

journal_name

Jpn J Infect Dis

authors

Colín-Ferreyra MDC,Domínguez-García MV,Mendieta-Zerón H,Camarillo-Romero MDS,Pérez-Rogel M,Martínez-Madrigal M,Martínez-Pérez S,Romero-Figueroa MDS

doi

10.7883/yoken.JJID.2019.289

subject

Has Abstract

pub_date

2020-03-24 00:00:00

pages

157-160

issue

2

eissn

1344-6304

issn

1884-2836

journal_volume

73

pub_type

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