Proteome-wide Data Analysis Reveals Tissue-specific Network Associated with SARS-CoV-2 Infection.

abstract：:The activity of dopaminergic neurons are thought to be increased by stimuli that predict reward and decreased by stimuli that predict aversive outcomes. Recent work by Matsumoto and Hikosaka challenges this model by asserting that stimuli associated with either rewarding or aversive outcomes increase the activity of d...

journal_title：Journal of molecular cell biology

authors： Frank MJ,Surmeier DJ

更新日期：2009-10-01 00:00:00

abstract：:E-selectin is a cell-adhesion molecule of the vascular endothelium that promotes essential leukocyte rolling in the early inflammatory response by binding to glycoproteins containing the tetrasaccharide sialyl Lewis(x) (sLe(x)). Efficient leukocyte recruitment under vascular flow conditions depends on an increased lif...

journal_title：Journal of molecular cell biology

authors： Preston RC,Jakob RP,Binder FP,Sager CP,Ernst B,Maier T

更新日期：2016-02-01 00:00:00

abstract：:The SMYD (SET and MYND domain) family of lysine methyltransferases (KMTs) plays pivotal roles in various cellular processes, including gene expression regulation and DNA damage response. Initially identified as genuine histone methyltransferases, specific members of this family have recently been shown to methylate no...

journal_title：Journal of molecular cell biology

authors： Abu-Farha M,Lanouette S,Elisma F,Tremblay V,Butson J,Figeys D,Couture JF

更新日期：2011-10-01 00:00:00

abstract：:Although genome-wide association studies (GWAS) have successfully identified thousands of genomic loci associated with hundreds of complex traits in the past decade, the debate about such problems as missing heritability and weak interpretability has been appealing for effective computational methods to facilitate the...

journal_title：Journal of molecular cell biology

authors： Wu M,Lin Z,Ma S,Chen T,Jiang R,Wong WH

更新日期：2017-12-01 00:00:00

abstract：:Inactivation of the p53 gene is a key driver of tumorigenesis in various cancer cohorts and types. The quest for a successful p53-based therapy that holds the promise of treating more than half of the cancer population has culminated in extensive knowledge about the role and function of p53 and led to new proposed inn...

journal_title：Journal of molecular cell biology

authors： Aning OA,Cheok CF

更新日期：2019-03-01 00:00:00

abstract：:Embryonic stem cells (ESCs) exhibit unique chromatin features, including a permissive transcriptional program and an open, decondensed chromatin state. Induced pluripotent stem cells (iPSCs), which are very similar to ESCs, hold great promise for therapy and basic research. However, the mechanisms by which reprogrammi...

journal_title：Journal of molecular cell biology

authors： Mattout A,Biran A,Meshorer E

更新日期：2011-12-01 00:00:00

abstract：:The MYC transcription factor plays a key role in cell growth control. Enhanced MYC protein stability has been found to promote tumorigenesis. Thus, understanding how MYC stability is controlled may have significant implications for revealing MYC-driven growth regulatory mechanisms in physiological and pathological pro...

journal_title：Journal of molecular cell biology

authors： Gonzalez-Pecchi V,Kwan AK,Doyle S,Ivanov AA,Du Y,Fu H

更新日期：2020-07-03 00:00:00

abstract：:Scaffolding proteins play pivotal roles in the assembly of macromolecular machines such as the spliceosome. The adaptor protein CD2BP2, originally identified as a binding partner of the adhesion molecule CD2, is a pre-spliceosomal assembly factor that utilizes its glycine-tyrosine-phenylalanine (GYF) domain to co-loca...

journal_title：Journal of molecular cell biology

authors： Albert GI,Schell C,Kirschner KM,Schäfer S,Naumann R,Müller A,Kretz O,Kuropka B,Girbig M,Hübner N,Krause E,Scholz H,Huber TB,Knobeloch KP,Freund C

更新日期：2015-10-01 00:00:00

abstract：:We previously identified that hepatitis B virus (HBV) encodes a microRNA (HBV-miR-3) that restrains HBV replication by targeting the HBV transcript. However, whether HBV-miR-3 affects host innate immunity to modulate HBV replication remains unclear. Here, we examined the vital functions of HBV-miR-3 in the innate immu...

journal_title：Journal of molecular cell biology

authors： Zhao X,Sun L,Mu T,Yi J,Ma C,Xie H,Liu M,Tang H

更新日期：2020-05-18 00:00:00

abstract：:TDP43 pathology is seen in a large majority of amyotrophic lateral sclerosis (ALS) cases, suggesting a central pathogenic role of this regulatory protein. Clarifying the molecular mechanism controlling TDP43 stability and subcellular location might provide important insights into ALS therapy. The ubiquitin E3 ligase R...

journal_title：Journal of molecular cell biology

authors： Ma P,Li Y,Wang H,Mao B

更新日期：2021-01-02 00:00:00

abstract：:Adipocyte is the most predominant cell type in the tumor microenvironment of breast cancer and plays a pivotal role in cancer progression, yet the underlying mechanisms and functional mediators remain elusive. We isolated primary preadipocytes from mammary fat pads of human breast cancer patients and generated mature ...

journal_title：Journal of molecular cell biology

authors： Liu L,Wu Y,Zhang C,Zhou C,Li Y,Zeng Y,Zhang C,Li R,Luo D,Wang L,Zhang L,Tu S,Deng H,Luo S,Chen YG,Xiong X,Yan X

更新日期：2020-09-01 00:00:00

abstract：:Understanding the mechanism of how cholangiocytes (liver ductal cells) are activated upon liver injury and specified to hepatocytes would permit liver regenerative medicine. Here we achieved long-term in vitro expansion of mouse liver organoids by modulating signaling pathways with a combination of three small-molecul...

journal_title：Journal of molecular cell biology

authors： Wang X,Ni C,Jiang N,Wei J,Liang J,Zhao B,Lin X

更新日期：2020-08-01 00:00:00

abstract：:The mouse double minute 4 (MDM4) is emerging from the shadow of its more famous relative MDM2 and is starting to steal the limelight, largely due to its therapeutic possibilities. MDM4 is a vital regulator of the tumor suppressor p53. It restricts p53 transcriptional activity and also, at least in development, facilit...

journal_title：Journal of molecular cell biology

authors： Haupt S,Mejía-Hernández JO,Vijayakumaran R,Keam SP,Haupt Y

更新日期：2019-03-01 00:00:00

abstract：:Type 2 immune response has been shown to facilitate cold-induced thermogenesis and browning of white fat. However, whether alternatively activated macrophages produce catecholamine and substantially promote adaptive thermogenesis in adipose tissue remains controversial. Here, we show that tyrosine hydroxylase (TyrH), ...

journal_title：Journal of molecular cell biology

authors： Luo Y,Liu B,Yang X,Ma X,Zhang X,Bragin DE,Yang XO,Huang W,Liu M

更新日期：2017-10-01 00:00:00

abstract：:The Hippo signalling pathway has a crucial role in growth control during development, and its dysregulation contributes to tumorigenesis. Recent studies uncover multiple upstream regulatory inputs into Hippo signalling, which affects phosphorylation of the transcriptional coactivator Yki/YAP/TAZ by Wts/Lats. Here we i...

journal_title：Journal of molecular cell biology

authors： Huang D,Li X,Sun L,Huang P,Ying H,Wang H,Wu J,Song H

更新日期：2016-08-01 00:00:00

abstract：:Histone deacetylase 1 (HDAC1) is an essential epigenetic regulator belonging to a highly conserved family of deacetylases. Increased HDAC1 activity and expression often correlates with neoplastic transformation. Here we show how specific modification of HDAC1 by SUMO1, but not by SUMO2, facilitates HDAC1 degradation. ...

journal_title：Journal of molecular cell biology

authors： Citro S,Jaffray E,Hay RT,Seiser C,Chiocca S

更新日期：2013-12-01 00:00:00

abstract：:Establishment of the primordial follicle (PF) pool is pivotal for the female reproductive lifespan; however, the mechanism of primordial folliculogenesis is poorly understood. Here, the transcription factor SP1 was shown to be essential for PF formation in mice. Our results showed that SP1 is present in both oocytes a...

journal_title：Journal of molecular cell biology

authors： Cai H,Liu B,Wang H,Sun G,Feng L,Chen Z,Zhou J,Zhang J,Zhang T,He M,Yang T,Guo Q,Teng Z,Xin Q,Zhou B,Zhang H,Xia G,Wang C

更新日期：2020-04-24 00:00:00

abstract：:Cells encountering hypoxic stress conserve resources and energy by downregulating the protein synthesis. Here we demonstrate that one mechanism in this response is the translational repression of TOP mRNAs that encode components of the translational apparatus. This mode of regulation involves TSC and Rheb, as knockout...

journal_title：Journal of molecular cell biology

authors： Miloslavski R,Cohen E,Avraham A,Iluz Y,Hayouka Z,Kasir J,Mudhasani R,Jones SN,Cybulski N,Rüegg MA,Larsson O,Gandin V,Rajakumar A,Topisirovic I,Meyuhas O

更新日期：2014-06-01 00:00:00

abstract：:Bacteria and archaea encode members of the large multiple antibiotic resistance regulator (MarR) family of transcriptional regulators. Generally, MarR homologs regulate activity of genes involved in antibiotic resistance, stress responses, virulence or catabolism of aromatic compounds. They constitute a diverse group ...

journal_title：Journal of molecular cell biology

authors： Perera IC,Grove A

更新日期：2010-10-01 00:00:00

abstract：:Haploid pluripotent stem cells, such as haploid embryonic stem cells (haESCs), facilitate the genetic study of recessive traits. In vitro, fish haESCs maintain haploidy in both undifferentiated and differentiated states, but whether mammalian haESCs can preserve pluripotency in the haploid state has not been tested. H...

journal_title：Journal of molecular cell biology

authors： Shuai L,Wang Y,Dong M,Wang X,Sang L,Wang M,Wan H,Luo G,Gu T,Yuan Y,Feng C,Teng F,Li W,Liu X,Li T,Wang L,Wang XJ,Zhao XY,Zhou Q

更新日期：2015-08-01 00:00:00

abstract：:Extracellular vesicles (EVs) carry signals within or at their limiting membranes, providing a mechanism by which cells can exchange more complex information than what was previously thought. In addition to mRNAs and microRNAs, there are DNA fragments in EVs. Solexa sequencing indicated the presence of at least 16434 g...

journal_title：Journal of molecular cell biology

authors： Cai J,Han Y,Ren H,Chen C,He D,Zhou L,Eisner GM,Asico LD,Jose PA,Zeng C

更新日期：2013-08-01 00:00:00

abstract：:Advances in functional genomics have led to discovery of a large group of previous uncharacterized long non-coding RNAs (lncRNAs). Emerging evidence indicates that lncRNAs may serve as master gene regulators through various mechanisms. Dysregulation of lncRNAs is often associated with a variety of human diseases inclu...

journal_title：Journal of molecular cell biology

authors： Zhang A,Xu M,Mo YY

更新日期：2014-06-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) replenish all types of blood cells. It is debating whether HSCs in adults solely originate from the aorta-gonad-mesonephros (AGM) region, more specifically, the dorsal aorta, during embryogenesis. Here, we report that somite hematopoiesis, a previously unwitnessed hematopoiesis, can gen...

journal_title：Journal of molecular cell biology

authors： Qiu J,Fan X,Wang Y,Jin H,Song Y,Han Y,Huang S,Meng Y,Tang F,Meng A

更新日期：2016-08-01 00:00:00

abstract：:OspE, a Shigella type III effector binds to integrin-like kinase and enhances cell adhesion to better disseminate and colonize the intestinal epithelium. Because of the existence of OspE orthologues in other enteropathogens such as enteropathogenic Escherichia coli or Salmonella sp., maintenance of cell adhesion appea...

journal_title：Journal of molecular cell biology

authors： Van Nhieu GT,Guignot J

更新日期：2009-12-01 00:00:00

abstract：:Breathing is an integrated motor behavior that is driven and controlled by a network of brainstem neurons. Zfhx4 is a zinc finger transcription factor and our results showed that it was specifically expressed in several regions of the mouse brainstem. Mice lacking Zfhx4 died shortly after birth from an apparent inabil...

journal_title：Journal of molecular cell biology

authors： Zhang M,Du S,Ou H,Cui R,Jiang N,Lin Y,Ge R,Ma D,Zhang J

更新日期：2021-01-20 00:00:00

abstract：:Motile cilia and flagella are microtubule-based organelles important for cell locomotion and extracellular liquid flow through beating. Although axonenal dyneins that drive ciliary beat have been extensively studied in unicellular Chlamydomonas, to what extent such knowledge can be applied to vertebrate is poorly know...

journal_title：Journal of molecular cell biology

authors： Zhang Y,Chen Y,Zheng J,Wang J,Duan S,Zhang W,Yan X,Zhu X

更新日期：2019-05-01 00:00:00

abstract：:RAD9 regulates multiple cellular processes that influence genomic integrity, and for at least some of its functions the protein acts as part of a heterotrimeric complex bound to HUS1 and RAD1 proteins. RAD9 participates in DNA repair, including base excision repair, homologous recombination repair and mismatch repair,...

journal_title：Journal of molecular cell biology

authors： Lieberman HB,Bernstock JD,Broustas CG,Hopkins KM,Leloup C,Zhu A

更新日期：2011-02-01 00:00:00

abstract：:The ectoderm has the capability to generate epidermis and neuroectoderm and plays imperative roles during the early embryonic development. Our recent study uncovered a region with ectodermal progenitor potential in mouse embryo at embryonic day 7.0 and revealed that Nodal inhibition is essential for its formation. Her...

journal_title：Journal of molecular cell biology

authors： Li L,Song L,Liu C,Chen J,Peng G,Wang R,Liu P,Tang K,Rossant J,Jing N

更新日期：2015-10-01 00:00:00

abstract：:X chromosome inactivation and genomic imprinting are two classic epigenetic regulatory processes that cause mono-allelic gene expression. In female mammals, mono-allelic expression of the long non-coding RNA gene X-inactive specific transcript (XIST) is essential for initiation of X chromosome inactivation upon differ...

journal_title：Journal of molecular cell biology

authors： Zhang Y,Wang C,Liu X,Yang Q,Ji H,Yang M,Xu M,Zhou Y,Xie W,Luo Z,Lin C

更新日期：2019-09-19 00:00:00

abstract：:Deregulation of microRNAs (miRNAs) and c-Myc (Myc) contributes to hepatocellular carcinoma (HCC) progression, but how miRNAs and Myc regulate each other in hepatocarcinogenesis is still poorly understood. Using a functional screen, we identified miR-129-5p as a miRNA that inhibits HCC cell growth. miR-129-5p targets t...

journal_title：Journal of molecular cell biology

authors： Han H,Li W,Shen H,Zhang J,Zhu Y,Li Y

更新日期：2016-10-01 00:00:00