Abstract：
:Breathing is an integrated motor behavior that is driven and controlled by a network of brainstem neurons. Zfhx4 is a zinc finger transcription factor and our results showed that it was specifically expressed in several regions of the mouse brainstem. Mice lacking Zfhx4 died shortly after birth from an apparent inability to initiate respiration. We also found that the electrical rhythm of brainstem‒spinal cord preparations was significantly depressed in Zfhx4-null mice compared to wild-type mice. Immunofluorescence staining revealed that Zfhx4 was co-expressed with Phox2b and Math1 in the brainstem and that Zfhx4 ablation greatly decreased the expression of these proteins, especially in the retrotrapezoid nucleus (RTN). Combined ChIP‒seq and mRNA expression microarray analysis identified Phox2b as the direct downstream target gene of Zfhx4, and this finding was validated by ChIP‒qPCR. Previous studies have reported that both Phox2b and Math1 play key roles in the development of the respiratory center, and Phox2b and Math1 knockout mice are neonatal lethal due to severe central apnea. On top of this, our study revealed that Zfhx4 is a critical regulator of Phox2b expression and essential for perinatal breathing.
journal_name
J Mol Cell Bioljournal_title
Journal of molecular cell biologyauthors
Zhang M,Du S,Ou H,Cui R,Jiang N,Lin Y,Ge R,Ma D,Zhang Jdoi
10.1093/jmcb/mjaa081subject
Has Abstractpub_date
2021-01-20 00:00:00eissn
1674-2788issn
1759-4685pii
6104894pub_type
杂志文章abstract：:Mesoangioblasts (MABs) are vessel-associated stem cells that express pericyte marker genes and participate in skeletal muscle regeneration. Molecular circuits that regulate the myogenic commitment of MABs are still poorly characterized. The critical role of bone morphogenetic protein (BMP) signalling during proliferat...
journal_title：Journal of molecular cell biology
pub_type： 杂志文章
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journal_title：Journal of molecular cell biology
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更新日期：2009-12-01 00:00:00
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journal_title：Journal of molecular cell biology
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更新日期：2010-08-01 00:00:00
abstract：:Understanding the mechanism of how cholangiocytes (liver ductal cells) are activated upon liver injury and specified to hepatocytes would permit liver regenerative medicine. Here we achieved long-term in vitro expansion of mouse liver organoids by modulating signaling pathways with a combination of three small-molecul...
journal_title：Journal of molecular cell biology
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更新日期：2020-08-01 00:00:00
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journal_title：Journal of molecular cell biology
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更新日期：2014-06-01 00:00:00
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journal_title：Journal of molecular cell biology
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journal_title：Journal of molecular cell biology
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更新日期：2020-07-08 00:00:00
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journal_title：Journal of molecular cell biology
pub_type： 杂志文章,评审
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更新日期：2019-03-01 00:00:00
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journal_title：Journal of molecular cell biology
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更新日期：2016-10-01 00:00:00
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journal_title：Journal of molecular cell biology
pub_type： 杂志文章
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更新日期：2009-10-01 00:00:00
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journal_title：Journal of molecular cell biology
pub_type： 杂志文章
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更新日期：2016-02-01 00:00:00
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journal_title：Journal of molecular cell biology
pub_type： 杂志文章
doi：10.1093/jmcb/mjq021
更新日期：2010-10-01 00:00:00
abstract：:Histone deacetylase 1 (HDAC1) is an essential epigenetic regulator belonging to a highly conserved family of deacetylases. Increased HDAC1 activity and expression often correlates with neoplastic transformation. Here we show how specific modification of HDAC1 by SUMO1, but not by SUMO2, facilitates HDAC1 degradation. ...
journal_title：Journal of molecular cell biology
pub_type： 杂志文章
doi：10.1093/jmcb/mjt032
更新日期：2013-12-01 00:00:00
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journal_title：Journal of molecular cell biology
pub_type： 杂志文章
doi：10.1093/jmcb/mjz056
更新日期：2019-09-19 00:00:00
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journal_title：Journal of molecular cell biology
pub_type： 杂志文章
doi：10.1093/jmcb/mjaa058
更新日期：2020-10-26 00:00:00
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journal_title：Journal of molecular cell biology
pub_type： 杂志文章,评审
doi：10.1093/jmcb/mjw046
更新日期：2017-02-01 00:00:00
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journal_title：Journal of molecular cell biology
pub_type： 杂志文章,评审
doi：10.1093/jmcb/mjz022
更新日期：2019-07-19 00:00:00
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journal_title：Journal of molecular cell biology
pub_type： 杂志文章
doi：10.1093/jmcb/mjq035
更新日期：2010-12-01 00:00:00
abstract：:Establishment of the primordial follicle (PF) pool is pivotal for the female reproductive lifespan; however, the mechanism of primordial folliculogenesis is poorly understood. Here, the transcription factor SP1 was shown to be essential for PF formation in mice. Our results showed that SP1 is present in both oocytes a...
journal_title：Journal of molecular cell biology
pub_type： 杂志文章
doi：10.1093/jmcb/mjz059
更新日期：2020-04-24 00:00:00
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journal_title：Journal of molecular cell biology
pub_type： 杂志文章
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更新日期：2009-12-01 00:00:00
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journal_title：Journal of molecular cell biology
pub_type： 杂志文章
doi：10.1093/jmcb/mjs038
更新日期：2012-12-01 00:00:00
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更新日期：2018-12-01 00:00:00
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更新日期：2015-10-01 00:00:00
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更新日期：2020-07-03 00:00:00
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journal_title：Journal of molecular cell biology
pub_type： 杂志文章
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更新日期：2017-04-01 00:00:00
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更新日期：2011-10-01 00:00:00
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更新日期：2011-08-01 00:00:00
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更新日期：2016-08-01 00:00:00
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