abstract：:Breathing is an integrated motor behavior that is driven and controlled by a network of brainstem neurons. Zfhx4 is a zinc finger transcription factor and our results showed that it was specifically expressed in several regions of the mouse brainstem. Mice lacking Zfhx4 died shortly after birth from an apparent inabil...

journal_title：Journal of molecular cell biology

authors： Zhang M,Du S,Ou H,Cui R,Jiang N,Lin Y,Ge R,Ma D,Zhang J

更新日期：2021-01-20 00:00:00

abstract：:TDP43 pathology is seen in a large majority of amyotrophic lateral sclerosis (ALS) cases, suggesting a central pathogenic role of this regulatory protein. Clarifying the molecular mechanism controlling TDP43 stability and subcellular location might provide important insights into ALS therapy. The ubiquitin E3 ligase R...

journal_title：Journal of molecular cell biology

authors： Ma P,Li Y,Wang H,Mao B

更新日期：2021-01-02 00:00:00

abstract：:Ever since gene targeting or specific modification of genome sequences in mice was achieved in the early 1980s, the reverse genetic approach of precise editing of any genomic locus has greatly accelerated biomedical research and biotechnology development. In particular, the recent development of the CRISPR/Cas9 system...

journal_title：Journal of molecular cell biology

authors： Wu Q,Shou J

更新日期：2020-10-30 00:00:00

abstract：:Local signaling events at synapses or axon terminals are communicated to the nucleus to elicit transcriptional responses, and thereby translate information about the external environment into internal neuronal representations. This retrograde signaling is critical to dendritic growth, synapse development, and neuronal...

journal_title：Journal of molecular cell biology

authors： Wu Y,Lv X,Wang H,Qian K,Ding J,Wang J,Hua S,Sun T,Zhou Y,Yu L,Qiu S

更新日期：2020-10-26 00:00:00

abstract：:Adipocyte is the most predominant cell type in the tumor microenvironment of breast cancer and plays a pivotal role in cancer progression, yet the underlying mechanisms and functional mediators remain elusive. We isolated primary preadipocytes from mammary fat pads of human breast cancer patients and generated mature ...

journal_title：Journal of molecular cell biology

authors： Liu L,Wu Y,Zhang C,Zhou C,Li Y,Zeng Y,Zhang C,Li R,Luo D,Wang L,Zhang L,Tu S,Deng H,Luo S,Chen YG,Xiong X,Yan X

更新日期：2020-09-01 00:00:00

abstract：:Mutations of epigenetic regulators are pervasive in human tumors. ASXL1 is frequently mutated in myeloid malignancies. We previously found that ASXL1 forms together with BAP1 a complex that can deubiquitinylate mono-ubiquitinylated lysine 119 on histone H2A (H2AK119ub1), a Polycomb repressive mark. However, a complete...

journal_title：Journal of molecular cell biology

authors： Cao L,Xia X,Kong Y,Jia F,Yuan B,Li R,Li Q,Wang Y,Cui M,Dai Z,Zheng H,Christensen J,Zhou Y,Wu X

更新日期：2020-09-01 00:00:00

abstract：:Understanding the mechanism of how cholangiocytes (liver ductal cells) are activated upon liver injury and specified to hepatocytes would permit liver regenerative medicine. Here we achieved long-term in vitro expansion of mouse liver organoids by modulating signaling pathways with a combination of three small-molecul...

journal_title：Journal of molecular cell biology

authors： Wang X,Ni C,Jiang N,Wei J,Liang J,Zhao B,Lin X

更新日期：2020-08-01 00:00:00

abstract：:For patients with COVID-19 caused by SARS-CoV-2, the damages to multiple organs have been clinically observed. Since most of current investigations for virus-host interaction are based on cell level, there is an urgent demand to probe tissue-specific features associated with SARS-CoV-2 infection. Based on collected pr...

journal_title：Journal of molecular cell biology

authors： Feng L,Yin YY,Liu CH,Xu KR,Li QR,Wu JR,Zeng R

更新日期：2020-07-08 00:00:00

abstract：:The MYC transcription factor plays a key role in cell growth control. Enhanced MYC protein stability has been found to promote tumorigenesis. Thus, understanding how MYC stability is controlled may have significant implications for revealing MYC-driven growth regulatory mechanisms in physiological and pathological pro...

journal_title：Journal of molecular cell biology

authors： Gonzalez-Pecchi V,Kwan AK,Doyle S,Ivanov AA,Du Y,Fu H

更新日期：2020-07-03 00:00:00

abstract：:We previously identified that hepatitis B virus (HBV) encodes a microRNA (HBV-miR-3) that restrains HBV replication by targeting the HBV transcript. However, whether HBV-miR-3 affects host innate immunity to modulate HBV replication remains unclear. Here, we examined the vital functions of HBV-miR-3 in the innate immu...

journal_title：Journal of molecular cell biology

authors： Zhao X,Sun L,Mu T,Yi J,Ma C,Xie H,Liu M,Tang H

更新日期：2020-05-18 00:00:00

abstract：:Establishment of the primordial follicle (PF) pool is pivotal for the female reproductive lifespan; however, the mechanism of primordial folliculogenesis is poorly understood. Here, the transcription factor SP1 was shown to be essential for PF formation in mice. Our results showed that SP1 is present in both oocytes a...

journal_title：Journal of molecular cell biology

authors： Cai H,Liu B,Wang H,Sun G,Feng L,Chen Z,Zhou J,Zhang J,Zhang T,He M,Yang T,Guo Q,Teng Z,Xin Q,Zhou B,Zhang H,Xia G,Wang C

更新日期：2020-04-24 00:00:00

abstract：:X chromosome inactivation and genomic imprinting are two classic epigenetic regulatory processes that cause mono-allelic gene expression. In female mammals, mono-allelic expression of the long non-coding RNA gene X-inactive specific transcript (XIST) is essential for initiation of X chromosome inactivation upon differ...

journal_title：Journal of molecular cell biology

authors： Zhang Y,Wang C,Liu X,Yang Q,Ji H,Yang M,Xu M,Zhou Y,Xie W,Luo Z,Lin C

更新日期：2019-09-19 00:00:00

abstract：:Increasing brown and beige fat thermogenesis have an anti-obesity effect and thus great metabolic benefits. However, the molecular mechanisms regulating brown and beige fat thermogenesis remain to be further elucidated. We recently found that fat-specific knockout of Rheb promoted beige fat thermogenesis. In the curre...

journal_title：Journal of molecular cell biology

authors： Meng W,Liang X,Xiao T,Wang J,Wen J,Luo H,Teng J,Fei Y,Zhang Q,Liu B,Hu F,Bai J,Liu M,Zhou Z,Liu F

更新日期：2019-09-19 00:00:00

abstract：:Analysis linking directly genomics, neuroimaging phenotypes and clinical measurements is crucial for understanding psychiatric disorders, but remains rare. Here, we describe a multi-scale analysis using genome-wide SNPs, gene expression, grey matter volume (GMV), and the positive and negative syndrome scale scores (PA...

journal_title：Journal of molecular cell biology

authors： Ma L,Rolls ET,Liu X,Liu Y,Jiao Z,Wang Y,Gong W,Ma Z,Gong F,Wan L

更新日期：2019-08-19 00:00:00

abstract：:Normal tissues are organized in a hierarchical model, whereas at the apex of these hierarchies reside stem cells (SCs) capable of self-renewal and of producing differentiated cellular progenies, leading to normal development and homeostasis. Alike, tumors are organized in a hierarchical manner, with cancer SCs residin...

journal_title：Journal of molecular cell biology

authors： Koifman G,Aloni-Grinstein R,Rotter V

更新日期：2019-07-19 00:00:00

abstract：:Motile cilia and flagella are microtubule-based organelles important for cell locomotion and extracellular liquid flow through beating. Although axonenal dyneins that drive ciliary beat have been extensively studied in unicellular Chlamydomonas, to what extent such knowledge can be applied to vertebrate is poorly know...

journal_title：Journal of molecular cell biology

authors： Zhang Y,Chen Y,Zheng J,Wang J,Duan S,Zhang W,Yan X,Zhu X

更新日期：2019-05-01 00:00:00

abstract：:The mouse double minute 4 (MDM4) is emerging from the shadow of its more famous relative MDM2 and is starting to steal the limelight, largely due to its therapeutic possibilities. MDM4 is a vital regulator of the tumor suppressor p53. It restricts p53 transcriptional activity and also, at least in development, facilit...

journal_title：Journal of molecular cell biology

authors： Haupt S,Mejía-Hernández JO,Vijayakumaran R,Keam SP,Haupt Y

更新日期：2019-03-01 00:00:00

abstract：:Inactivation of the p53 gene is a key driver of tumorigenesis in various cancer cohorts and types. The quest for a successful p53-based therapy that holds the promise of treating more than half of the cancer population has culminated in extensive knowledge about the role and function of p53 and led to new proposed inn...

journal_title：Journal of molecular cell biology

authors： Aning OA,Cheok CF

更新日期：2019-03-01 00:00:00

abstract：:Mammalian fertilization involves membrane events-adhesion, fusion, sperm engulfment, membrane block to polyspermy-whose causes remain largely unknown. Recently, specific oscillations of the sperm in contact with the egg were shown to be necessary for fusion. Using a microfluidic chip to impose the venue for the encoun...

journal_title：Journal of molecular cell biology

authors： Ravaux B,Favier S,Perez E,Gourier C

更新日期：2018-12-01 00:00:00

abstract：:We present a computational study of tissue transcriptomic data of 14 cancer types to address: what may drive cancer cell division? Our analyses point to that persistent disruption of the intracellular pH by Fenton reactions may be at the root of cancer development. Specifically, we have statistically demonstrated that...

journal_title：Journal of molecular cell biology

authors： Sun H,Zhang C,Cao S,Sheng T,Dong N,Xu Y

更新日期：2018-10-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC), characterized by the lack of expression of the estrogen receptor, the progesterone receptor, and the human epidermal growth factor receptor 2, is an aggressive form of cancer that conveys unpredictable and poor prognosis due to limited treatment options and lack of effective targe...

journal_title：Journal of molecular cell biology

authors： Liu S,Wang Z,Liu Z,Shi S,Zhang Z,Zhang J,Lin H

更新日期：2018-08-01 00:00:00

abstract：:Although genome-wide association studies (GWAS) have successfully identified thousands of genomic loci associated with hundreds of complex traits in the past decade, the debate about such problems as missing heritability and weak interpretability has been appealing for effective computational methods to facilitate the...

journal_title：Journal of molecular cell biology

authors： Wu M,Lin Z,Ma S,Chen T,Jiang R,Wong WH

更新日期：2017-12-01 00:00:00

abstract：:Type 2 immune response has been shown to facilitate cold-induced thermogenesis and browning of white fat. However, whether alternatively activated macrophages produce catecholamine and substantially promote adaptive thermogenesis in adipose tissue remains controversial. Here, we show that tyrosine hydroxylase (TyrH), ...

journal_title：Journal of molecular cell biology

authors： Luo Y,Liu B,Yang X,Ma X,Zhang X,Bragin DE,Yang XO,Huang W,Liu M

更新日期：2017-10-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is a highly invasive brain tumor with limited therapeutic means and poor prognosis. Recent studies indicate that glioma-initiating cells/glioma stem cells (GICs/GSCs) may be responsible for tumor initiation, infiltration, and recurrence. GICs could aberrantly employ molecular machinery ba...

journal_title：Journal of molecular cell biology

authors： Li Y,Wang W,Wang F,Wu Q,Li W,Zhong X,Tian K,Zeng T,Gao L,Liu Y,Li S,Jiang X,Du G,Zhou Y

更新日期：2017-08-01 00:00:00

abstract：:Homoeostatic regulation of the light sensor, rhodopsin, is critical for the maintenance of light sensitivity and survival of photoreceptors. The major fly rhodopsin, Rh1, undergoes light-induced endocytosis and degradation, but its protein and mRNA levels remain constant during light/dark cycles. It is not clear how t...

journal_title：Journal of molecular cell biology

authors： Wang X,Mu Y,Sun M,Han J

更新日期：2017-04-01 00:00:00

abstract：:Mdm2 is the key negative regulator of the tumour suppressor p53, making it an attractive target for anti-cancer drug design. We recently identified a new role of Mdm2 in gene repression through its direct interaction with several proteins of the polycomb group (PcG) family. PcG proteins form polycomb repressive comple...

journal_title：Journal of molecular cell biology

authors： Wienken M,Moll UM,Dobbelstein M

更新日期：2017-02-01 00:00:00

abstract：:Deregulation of microRNAs (miRNAs) and c-Myc (Myc) contributes to hepatocellular carcinoma (HCC) progression, but how miRNAs and Myc regulate each other in hepatocarcinogenesis is still poorly understood. Using a functional screen, we identified miR-129-5p as a miRNA that inhibits HCC cell growth. miR-129-5p targets t...

journal_title：Journal of molecular cell biology

authors： Han H,Li W,Shen H,Zhang J,Zhu Y,Li Y

更新日期：2016-10-01 00:00:00

abstract：:HIV-Tat-interacting protein of 60 kDa (TIP60) is a lysine acetyltransferase and known to be downregulated in multiple cancers. Among various signalling pathways, TIP60 is implicated in regulating epithelial-mesenchymal transition (EMT). Here, we show that TIP60 expression abrogates cell migration and metastatic potent...

journal_title：Journal of molecular cell biology

authors： Zhang Y,Subbaiah VK,Rajagopalan D,Tham CY,Abdullah LN,Toh TB,Gong M,Tan TZ,Jadhav SP,Pandey AK,Karnani N,Chow EK,Thiery JP,Jha S

更新日期：2016-10-01 00:00:00

abstract：:The Hippo signalling pathway has a crucial role in growth control during development, and its dysregulation contributes to tumorigenesis. Recent studies uncover multiple upstream regulatory inputs into Hippo signalling, which affects phosphorylation of the transcriptional coactivator Yki/YAP/TAZ by Wts/Lats. Here we i...

journal_title：Journal of molecular cell biology

authors： Huang D,Li X,Sun L,Huang P,Ying H,Wang H,Wu J,Song H

更新日期：2016-08-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) replenish all types of blood cells. It is debating whether HSCs in adults solely originate from the aorta-gonad-mesonephros (AGM) region, more specifically, the dorsal aorta, during embryogenesis. Here, we report that somite hematopoiesis, a previously unwitnessed hematopoiesis, can gen...

journal_title：Journal of molecular cell biology

authors： Qiu J,Fan X,Wang Y,Jin H,Song Y,Han Y,Huang S,Meng Y,Tang F,Meng A

更新日期：2016-08-01 00:00:00

abstract：:E-selectin is a cell-adhesion molecule of the vascular endothelium that promotes essential leukocyte rolling in the early inflammatory response by binding to glycoproteins containing the tetrasaccharide sialyl Lewis(x) (sLe(x)). Efficient leukocyte recruitment under vascular flow conditions depends on an increased lif...

journal_title：Journal of molecular cell biology

authors： Preston RC,Jakob RP,Binder FP,Sager CP,Ernst B,Maier T

更新日期：2016-02-01 00:00:00

abstract：:Mesoangioblasts (MABs) are vessel-associated stem cells that express pericyte marker genes and participate in skeletal muscle regeneration. Molecular circuits that regulate the myogenic commitment of MABs are still poorly characterized. The critical role of bone morphogenetic protein (BMP) signalling during proliferat...

journal_title：Journal of molecular cell biology

authors： Costamagna D,Quattrocelli M,van Tienen F,Umans L,de Coo IF,Zwijsen A,Huylebroeck D,Sampaolesi M

更新日期：2016-02-01 00:00:00

abstract：:Scaffolding proteins play pivotal roles in the assembly of macromolecular machines such as the spliceosome. The adaptor protein CD2BP2, originally identified as a binding partner of the adhesion molecule CD2, is a pre-spliceosomal assembly factor that utilizes its glycine-tyrosine-phenylalanine (GYF) domain to co-loca...

journal_title：Journal of molecular cell biology

authors： Albert GI,Schell C,Kirschner KM,Schäfer S,Naumann R,Müller A,Kretz O,Kuropka B,Girbig M,Hübner N,Krause E,Scholz H,Huber TB,Knobeloch KP,Freund C

更新日期：2015-10-01 00:00:00

abstract：:The cranial neural crest (CNC) cells play a vital role in craniofacial development and regeneration. They are multi-potent progenitors, being able to differentiate into various types of tissues. Both pre-migratory and post-migratory CNC cells are plastic, taking on diverse fates by responding to different inductive si...

journal_title：Journal of molecular cell biology

authors： Shao M,Liu C,Song Y,Ye W,He W,Yuan G,Gu S,Lin C,Ma L,Zhang Y,Tian W,Hu T,Chen Y

更新日期：2015-10-01 00:00:00

abstract：:The ectoderm has the capability to generate epidermis and neuroectoderm and plays imperative roles during the early embryonic development. Our recent study uncovered a region with ectodermal progenitor potential in mouse embryo at embryonic day 7.0 and revealed that Nodal inhibition is essential for its formation. Her...

journal_title：Journal of molecular cell biology

authors： Li L,Song L,Liu C,Chen J,Peng G,Wang R,Liu P,Tang K,Rossant J,Jing N

更新日期：2015-10-01 00:00:00

abstract：:Haploid pluripotent stem cells, such as haploid embryonic stem cells (haESCs), facilitate the genetic study of recessive traits. In vitro, fish haESCs maintain haploidy in both undifferentiated and differentiated states, but whether mammalian haESCs can preserve pluripotency in the haploid state has not been tested. H...

journal_title：Journal of molecular cell biology

authors： Shuai L,Wang Y,Dong M,Wang X,Sang L,Wang M,Wan H,Luo G,Gu T,Yuan Y,Feng C,Teng F,Li W,Liu X,Li T,Wang L,Wang XJ,Zhao XY,Zhou Q

更新日期：2015-08-01 00:00:00

abstract：:Our earlier studies have demonstrated that the cigarette smoke in the form of cigarette smoke condensate (CSC) causes growth arrest of a mouse spermatocyte cell line [GC-2spd(ts)] through activation of the AHR-NRF2 pathway. The present study demonstrates the CSC-activated p38 and ERK MAPK signaling in GC-2spd(ts) via ...

journal_title：Journal of molecular cell biology

authors： Esakky P,Hansen DA,Drury AM,Moley KH

更新日期：2015-02-01 00:00:00

abstract：:Cells encountering hypoxic stress conserve resources and energy by downregulating the protein synthesis. Here we demonstrate that one mechanism in this response is the translational repression of TOP mRNAs that encode components of the translational apparatus. This mode of regulation involves TSC and Rheb, as knockout...

journal_title：Journal of molecular cell biology

authors： Miloslavski R,Cohen E,Avraham A,Iluz Y,Hayouka Z,Kasir J,Mudhasani R,Jones SN,Cybulski N,Rüegg MA,Larsson O,Gandin V,Rajakumar A,Topisirovic I,Meyuhas O

更新日期：2014-06-01 00:00:00

abstract：:Advances in functional genomics have led to discovery of a large group of previous uncharacterized long non-coding RNAs (lncRNAs). Emerging evidence indicates that lncRNAs may serve as master gene regulators through various mechanisms. Dysregulation of lncRNAs is often associated with a variety of human diseases inclu...

journal_title：Journal of molecular cell biology

authors： Zhang A,Xu M,Mo YY

更新日期：2014-06-01 00:00:00

abstract：:Histone deacetylase 1 (HDAC1) is an essential epigenetic regulator belonging to a highly conserved family of deacetylases. Increased HDAC1 activity and expression often correlates with neoplastic transformation. Here we show how specific modification of HDAC1 by SUMO1, but not by SUMO2, facilitates HDAC1 degradation. ...

journal_title：Journal of molecular cell biology

authors： Citro S,Jaffray E,Hay RT,Seiser C,Chiocca S

更新日期：2013-12-01 00:00:00