Embryonic hematopoiesis in vertebrate somites gives rise to definitive hematopoietic stem cells.

Abstract:

:Hematopoietic stem cells (HSCs) replenish all types of blood cells. It is debating whether HSCs in adults solely originate from the aorta-gonad-mesonephros (AGM) region, more specifically, the dorsal aorta, during embryogenesis. Here, we report that somite hematopoiesis, a previously unwitnessed hematopoiesis, can generate definitive HSCs (dHSCs) in zebrafish. By transgenic lineage tracing, we found that a subset of cells within the forming somites emigrate ventromedially and mix with lateral plate mesoderm-derived primitive hematopoietic cells before the blood circulation starts. These somite-derived hematopoietic precursors and stem cells (sHPSCs) subsequently enter the circulation and colonize the kidney of larvae and adults. RNA-seq analysis reveals that sHPSCs express hematopoietic genes with sustained expression of many muscle/skeletal genes. Embryonic sHPSCs transplanted into wild-type embryos expand during growth and survive for life time with differentiation into various hematopoietic lineages, indicating self-renewal and multipotency features. Therefore, the embryonic origin of dHSCs in adults is not restricted to the AGM.

journal_name

J Mol Cell Biol

authors

Qiu J,Fan X,Wang Y,Jin H,Song Y,Han Y,Huang S,Meng Y,Tang F,Meng A

doi

10.1093/jmcb/mjw024

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

288-301

issue

4

eissn

1674-2788

issn

1759-4685

pii

mjw024

journal_volume

8

pub_type

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