Cancer-associated adipocyte-derived G-CSF promotes breast cancer malignancy via Stat3 signaling.

abstract：:X chromosome inactivation and genomic imprinting are two classic epigenetic regulatory processes that cause mono-allelic gene expression. In female mammals, mono-allelic expression of the long non-coding RNA gene X-inactive specific transcript (XIST) is essential for initiation of X chromosome inactivation upon differ...

journal_title：Journal of molecular cell biology

authors： Zhang Y,Wang C,Liu X,Yang Q,Ji H,Yang M,Xu M,Zhou Y,Xie W,Luo Z,Lin C

更新日期：2019-09-19 00:00:00

abstract：:Mutations of epigenetic regulators are pervasive in human tumors. ASXL1 is frequently mutated in myeloid malignancies. We previously found that ASXL1 forms together with BAP1 a complex that can deubiquitinylate mono-ubiquitinylated lysine 119 on histone H2A (H2AK119ub1), a Polycomb repressive mark. However, a complete...

journal_title：Journal of molecular cell biology

authors： Cao L,Xia X,Kong Y,Jia F,Yuan B,Li R,Li Q,Wang Y,Cui M,Dai Z,Zheng H,Christensen J,Zhou Y,Wu X

更新日期：2020-09-01 00:00:00

abstract：:The MYC transcription factor plays a key role in cell growth control. Enhanced MYC protein stability has been found to promote tumorigenesis. Thus, understanding how MYC stability is controlled may have significant implications for revealing MYC-driven growth regulatory mechanisms in physiological and pathological pro...

journal_title：Journal of molecular cell biology

authors： Gonzalez-Pecchi V,Kwan AK,Doyle S,Ivanov AA,Du Y,Fu H

更新日期：2020-07-03 00:00:00

abstract：:OspE, a Shigella type III effector binds to integrin-like kinase and enhances cell adhesion to better disseminate and colonize the intestinal epithelium. Because of the existence of OspE orthologues in other enteropathogens such as enteropathogenic Escherichia coli or Salmonella sp., maintenance of cell adhesion appea...

journal_title：Journal of molecular cell biology

authors： Van Nhieu GT,Guignot J

更新日期：2009-12-01 00:00:00

abstract：:Histone deacetylase 1 (HDAC1) is an essential epigenetic regulator belonging to a highly conserved family of deacetylases. Increased HDAC1 activity and expression often correlates with neoplastic transformation. Here we show how specific modification of HDAC1 by SUMO1, but not by SUMO2, facilitates HDAC1 degradation. ...

journal_title：Journal of molecular cell biology

authors： Citro S,Jaffray E,Hay RT,Seiser C,Chiocca S

更新日期：2013-12-01 00:00:00

abstract：:We previously identified that hepatitis B virus (HBV) encodes a microRNA (HBV-miR-3) that restrains HBV replication by targeting the HBV transcript. However, whether HBV-miR-3 affects host innate immunity to modulate HBV replication remains unclear. Here, we examined the vital functions of HBV-miR-3 in the innate immu...

journal_title：Journal of molecular cell biology

authors： Zhao X,Sun L,Mu T,Yi J,Ma C,Xie H,Liu M,Tang H

更新日期：2020-05-18 00:00:00

abstract：:Haploid pluripotent stem cells, such as haploid embryonic stem cells (haESCs), facilitate the genetic study of recessive traits. In vitro, fish haESCs maintain haploidy in both undifferentiated and differentiated states, but whether mammalian haESCs can preserve pluripotency in the haploid state has not been tested. H...

journal_title：Journal of molecular cell biology

authors： Shuai L,Wang Y,Dong M,Wang X,Sang L,Wang M,Wan H,Luo G,Gu T,Yuan Y,Feng C,Teng F,Li W,Liu X,Li T,Wang L,Wang XJ,Zhao XY,Zhou Q

更新日期：2015-08-01 00:00:00

abstract：:The ectoderm has the capability to generate epidermis and neuroectoderm and plays imperative roles during the early embryonic development. Our recent study uncovered a region with ectodermal progenitor potential in mouse embryo at embryonic day 7.0 and revealed that Nodal inhibition is essential for its formation. Her...

journal_title：Journal of molecular cell biology

authors： Li L,Song L,Liu C,Chen J,Peng G,Wang R,Liu P,Tang K,Rossant J,Jing N

更新日期：2015-10-01 00:00:00

abstract：:Establishment of the primordial follicle (PF) pool is pivotal for the female reproductive lifespan; however, the mechanism of primordial folliculogenesis is poorly understood. Here, the transcription factor SP1 was shown to be essential for PF formation in mice. Our results showed that SP1 is present in both oocytes a...

journal_title：Journal of molecular cell biology

authors： Cai H,Liu B,Wang H,Sun G,Feng L,Chen Z,Zhou J,Zhang J,Zhang T,He M,Yang T,Guo Q,Teng Z,Xin Q,Zhou B,Zhang H,Xia G,Wang C

更新日期：2020-04-24 00:00:00

abstract：:RAD9 regulates multiple cellular processes that influence genomic integrity, and for at least some of its functions the protein acts as part of a heterotrimeric complex bound to HUS1 and RAD1 proteins. RAD9 participates in DNA repair, including base excision repair, homologous recombination repair and mismatch repair,...

journal_title：Journal of molecular cell biology

authors： Lieberman HB,Bernstock JD,Broustas CG,Hopkins KM,Leloup C,Zhu A

更新日期：2011-02-01 00:00:00

abstract：:Deregulation of microRNAs (miRNAs) and c-Myc (Myc) contributes to hepatocellular carcinoma (HCC) progression, but how miRNAs and Myc regulate each other in hepatocarcinogenesis is still poorly understood. Using a functional screen, we identified miR-129-5p as a miRNA that inhibits HCC cell growth. miR-129-5p targets t...

journal_title：Journal of molecular cell biology

authors： Han H,Li W,Shen H,Zhang J,Zhu Y,Li Y

更新日期：2016-10-01 00:00:00

abstract：:Although genome-wide association studies (GWAS) have successfully identified thousands of genomic loci associated with hundreds of complex traits in the past decade, the debate about such problems as missing heritability and weak interpretability has been appealing for effective computational methods to facilitate the...

journal_title：Journal of molecular cell biology

authors： Wu M,Lin Z,Ma S,Chen T,Jiang R,Wong WH

更新日期：2017-12-01 00:00:00

abstract：:E-selectin is a cell-adhesion molecule of the vascular endothelium that promotes essential leukocyte rolling in the early inflammatory response by binding to glycoproteins containing the tetrasaccharide sialyl Lewis(x) (sLe(x)). Efficient leukocyte recruitment under vascular flow conditions depends on an increased lif...

journal_title：Journal of molecular cell biology

authors： Preston RC,Jakob RP,Binder FP,Sager CP,Ernst B,Maier T

更新日期：2016-02-01 00:00:00

abstract：:Type 2 immune response has been shown to facilitate cold-induced thermogenesis and browning of white fat. However, whether alternatively activated macrophages produce catecholamine and substantially promote adaptive thermogenesis in adipose tissue remains controversial. Here, we show that tyrosine hydroxylase (TyrH), ...

journal_title：Journal of molecular cell biology

authors： Luo Y,Liu B,Yang X,Ma X,Zhang X,Bragin DE,Yang XO,Huang W,Liu M

更新日期：2017-10-01 00:00:00

abstract：:Advances in functional genomics have led to discovery of a large group of previous uncharacterized long non-coding RNAs (lncRNAs). Emerging evidence indicates that lncRNAs may serve as master gene regulators through various mechanisms. Dysregulation of lncRNAs is often associated with a variety of human diseases inclu...

journal_title：Journal of molecular cell biology

authors： Zhang A,Xu M,Mo YY

更新日期：2014-06-01 00:00:00

abstract：:Analysis linking directly genomics, neuroimaging phenotypes and clinical measurements is crucial for understanding psychiatric disorders, but remains rare. Here, we describe a multi-scale analysis using genome-wide SNPs, gene expression, grey matter volume (GMV), and the positive and negative syndrome scale scores (PA...

journal_title：Journal of molecular cell biology

authors： Ma L,Rolls ET,Liu X,Liu Y,Jiao Z,Wang Y,Gong W,Ma Z,Gong F,Wan L

更新日期：2019-08-19 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) is a protein kinase that plays key roles in cellular regulation. It forms complexes with additional proteins. The best-understood one is mTOR complex 1 (mTORC1). The regulation and cellular functions of mTORC1 have been the subjects of intense study; despite this, many question...

journal_title：Journal of molecular cell biology

authors： Wang X,Proud CG

更新日期：2011-08-01 00:00:00

abstract：:SRY-related HMG-box gene 2 (SOX2) is one of the key regulatory genes that maintain the pluripotency and self-renewal properties in embryonic stem cells. Here we used immunohistochemistry to analyze the expression of SOX2 in human prostate tissues and found it contributed to tumorigenesis and correlated with histologic...

journal_title：Journal of molecular cell biology

authors： Jia X,Li X,Xu Y,Zhang S,Mou W,Liu Y,Liu Y,Lv D,Liu CH,Tan X,Xiang R,Li N

更新日期：2011-08-01 00:00:00

abstract：:Our earlier studies have demonstrated that the cigarette smoke in the form of cigarette smoke condensate (CSC) causes growth arrest of a mouse spermatocyte cell line [GC-2spd(ts)] through activation of the AHR-NRF2 pathway. The present study demonstrates the CSC-activated p38 and ERK MAPK signaling in GC-2spd(ts) via ...

journal_title：Journal of molecular cell biology

authors： Esakky P,Hansen DA,Drury AM,Moley KH

更新日期：2015-02-01 00:00:00

abstract：:Extracellular vesicles (EVs) carry signals within or at their limiting membranes, providing a mechanism by which cells can exchange more complex information than what was previously thought. In addition to mRNAs and microRNAs, there are DNA fragments in EVs. Solexa sequencing indicated the presence of at least 16434 g...

journal_title：Journal of molecular cell biology

authors： Cai J,Han Y,Ren H,Chen C,He D,Zhou L,Eisner GM,Asico LD,Jose PA,Zeng C

更新日期：2013-08-01 00:00:00

abstract：:Ever since gene targeting or specific modification of genome sequences in mice was achieved in the early 1980s, the reverse genetic approach of precise editing of any genomic locus has greatly accelerated biomedical research and biotechnology development. In particular, the recent development of the CRISPR/Cas9 system...

journal_title：Journal of molecular cell biology

authors： Wu Q,Shou J

更新日期：2020-10-30 00:00:00

abstract：:Mycobacterium tuberculosis is one of the most notorious killers worldwide. These pathogens have evolved to infect human beings in a so-called dormant form that is extremely difficult to treat. New work, however, suggests that mycobacterial proteasomes, multicomponent structures that protect the microbe from damaging e...

journal_title：Journal of molecular cell biology

authors： Cheng Y,Pieters J

更新日期：2010-08-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC), characterized by the lack of expression of the estrogen receptor, the progesterone receptor, and the human epidermal growth factor receptor 2, is an aggressive form of cancer that conveys unpredictable and poor prognosis due to limited treatment options and lack of effective targe...

journal_title：Journal of molecular cell biology

authors： Liu S,Wang Z,Liu Z,Shi S,Zhang Z,Zhang J,Lin H

更新日期：2018-08-01 00:00:00

abstract：:Human colon carcinomas (CCs) represent a growing worldwide problem. One of the pathways that has been negatively implicated in the genesis of CCs is triggered by bone morphogenetic protein (BMP) ligands, which activate BMP receptors leading to the function of SMAD proteins in the nucleus. BMP signaling is altered in f...

journal_title：Journal of molecular cell biology

authors： Lorente-Trigos A,Varnat F,Melotti A,Ruiz i Altaba A

更新日期：2010-12-01 00:00:00

abstract：:Inactivation of the p53 gene is a key driver of tumorigenesis in various cancer cohorts and types. The quest for a successful p53-based therapy that holds the promise of treating more than half of the cancer population has culminated in extensive knowledge about the role and function of p53 and led to new proposed inn...

journal_title：Journal of molecular cell biology

authors： Aning OA,Cheok CF

更新日期：2019-03-01 00:00:00

abstract：:Dying cells actively attract professional phagocytes by sending out soluble 'find-me' signals. The characterization and identification of the corresponding molecular entities have revealed that 'find-me' signals come in different flavors, including peptides, proteins, lipids and complex structures, such as apoptotic m...

journal_title：Journal of molecular cell biology

authors： Peter C,Wesselborg S,Lauber K

更新日期：2010-04-01 00:00:00

abstract：:Cells encountering hypoxic stress conserve resources and energy by downregulating the protein synthesis. Here we demonstrate that one mechanism in this response is the translational repression of TOP mRNAs that encode components of the translational apparatus. This mode of regulation involves TSC and Rheb, as knockout...

journal_title：Journal of molecular cell biology

authors： Miloslavski R,Cohen E,Avraham A,Iluz Y,Hayouka Z,Kasir J,Mudhasani R,Jones SN,Cybulski N,Rüegg MA,Larsson O,Gandin V,Rajakumar A,Topisirovic I,Meyuhas O

更新日期：2014-06-01 00:00:00

abstract：:We present a computational study of tissue transcriptomic data of 14 cancer types to address: what may drive cancer cell division? Our analyses point to that persistent disruption of the intracellular pH by Fenton reactions may be at the root of cancer development. Specifically, we have statistically demonstrated that...

journal_title：Journal of molecular cell biology

authors： Sun H,Zhang C,Cao S,Sheng T,Dong N,Xu Y

更新日期：2018-10-01 00:00:00

abstract：:Mesoangioblasts (MABs) are vessel-associated stem cells that express pericyte marker genes and participate in skeletal muscle regeneration. Molecular circuits that regulate the myogenic commitment of MABs are still poorly characterized. The critical role of bone morphogenetic protein (BMP) signalling during proliferat...

journal_title：Journal of molecular cell biology

authors： Costamagna D,Quattrocelli M,van Tienen F,Umans L,de Coo IF,Zwijsen A,Huylebroeck D,Sampaolesi M

更新日期：2016-02-01 00:00:00

abstract：:HIV-Tat-interacting protein of 60 kDa (TIP60) is a lysine acetyltransferase and known to be downregulated in multiple cancers. Among various signalling pathways, TIP60 is implicated in regulating epithelial-mesenchymal transition (EMT). Here, we show that TIP60 expression abrogates cell migration and metastatic potent...

journal_title：Journal of molecular cell biology

authors： Zhang Y,Subbaiah VK,Rajagopalan D,Tham CY,Abdullah LN,Toh TB,Gong M,Tan TZ,Jadhav SP,Pandey AK,Karnani N,Chow EK,Thiery JP,Jha S

更新日期：2016-10-01 00:00:00