mTORC1 signaling: what we still don't know.

abstract：:Establishment of the primordial follicle (PF) pool is pivotal for the female reproductive lifespan; however, the mechanism of primordial folliculogenesis is poorly understood. Here, the transcription factor SP1 was shown to be essential for PF formation in mice. Our results showed that SP1 is present in both oocytes a...

journal_title：Journal of molecular cell biology

authors： Cai H,Liu B,Wang H,Sun G,Feng L,Chen Z,Zhou J,Zhang J,Zhang T,He M,Yang T,Guo Q,Teng Z,Xin Q,Zhou B,Zhang H,Xia G,Wang C

更新日期：2020-04-24 00:00:00

abstract：:Mammalian fertilization involves membrane events-adhesion, fusion, sperm engulfment, membrane block to polyspermy-whose causes remain largely unknown. Recently, specific oscillations of the sperm in contact with the egg were shown to be necessary for fusion. Using a microfluidic chip to impose the venue for the encoun...

journal_title：Journal of molecular cell biology

authors： Ravaux B,Favier S,Perez E,Gourier C

更新日期：2018-12-01 00:00:00

abstract：:As many human sensory and cognitive diseases are caused by irreversible damage or loss of certain types of neurons, methodologies aimed at replacement of lost neurons are key to restore lost sensation. Recent advances in generation of ear-cell progenitors, optic-cup structures and cortical neurons from human embryonic...

journal_title：Journal of molecular cell biology

authors： Zhang K,Yi F,Liu GH,Belmonte JC

更新日期：2013-04-01 00:00:00

abstract：:Normal tissues are organized in a hierarchical model, whereas at the apex of these hierarchies reside stem cells (SCs) capable of self-renewal and of producing differentiated cellular progenies, leading to normal development and homeostasis. Alike, tumors are organized in a hierarchical manner, with cancer SCs residin...

journal_title：Journal of molecular cell biology

authors： Koifman G,Aloni-Grinstein R,Rotter V

更新日期：2019-07-19 00:00:00

abstract：:Hematopoietic stem cells (HSCs) replenish all types of blood cells. It is debating whether HSCs in adults solely originate from the aorta-gonad-mesonephros (AGM) region, more specifically, the dorsal aorta, during embryogenesis. Here, we report that somite hematopoiesis, a previously unwitnessed hematopoiesis, can gen...

journal_title：Journal of molecular cell biology

authors： Qiu J,Fan X,Wang Y,Jin H,Song Y,Han Y,Huang S,Meng Y,Tang F,Meng A

更新日期：2016-08-01 00:00:00

abstract：:The activity of dopaminergic neurons are thought to be increased by stimuli that predict reward and decreased by stimuli that predict aversive outcomes. Recent work by Matsumoto and Hikosaka challenges this model by asserting that stimuli associated with either rewarding or aversive outcomes increase the activity of d...

journal_title：Journal of molecular cell biology

authors： Frank MJ,Surmeier DJ

更新日期：2009-10-01 00:00:00

abstract：:Homoeostatic regulation of the light sensor, rhodopsin, is critical for the maintenance of light sensitivity and survival of photoreceptors. The major fly rhodopsin, Rh1, undergoes light-induced endocytosis and degradation, but its protein and mRNA levels remain constant during light/dark cycles. It is not clear how t...

journal_title：Journal of molecular cell biology

authors： Wang X,Mu Y,Sun M,Han J

更新日期：2017-04-01 00:00:00

abstract：:Mutations of epigenetic regulators are pervasive in human tumors. ASXL1 is frequently mutated in myeloid malignancies. We previously found that ASXL1 forms together with BAP1 a complex that can deubiquitinylate mono-ubiquitinylated lysine 119 on histone H2A (H2AK119ub1), a Polycomb repressive mark. However, a complete...

journal_title：Journal of molecular cell biology

authors： Cao L,Xia X,Kong Y,Jia F,Yuan B,Li R,Li Q,Wang Y,Cui M,Dai Z,Zheng H,Christensen J,Zhou Y,Wu X

更新日期：2020-09-01 00:00:00

abstract：:Extracellular vesicles (EVs) carry signals within or at their limiting membranes, providing a mechanism by which cells can exchange more complex information than what was previously thought. In addition to mRNAs and microRNAs, there are DNA fragments in EVs. Solexa sequencing indicated the presence of at least 16434 g...

journal_title：Journal of molecular cell biology

authors： Cai J,Han Y,Ren H,Chen C,He D,Zhou L,Eisner GM,Asico LD,Jose PA,Zeng C

更新日期：2013-08-01 00:00:00

abstract：:E-selectin is a cell-adhesion molecule of the vascular endothelium that promotes essential leukocyte rolling in the early inflammatory response by binding to glycoproteins containing the tetrasaccharide sialyl Lewis(x) (sLe(x)). Efficient leukocyte recruitment under vascular flow conditions depends on an increased lif...

journal_title：Journal of molecular cell biology

authors： Preston RC,Jakob RP,Binder FP,Sager CP,Ernst B,Maier T

更新日期：2016-02-01 00:00:00

abstract：:Haploid pluripotent stem cells, such as haploid embryonic stem cells (haESCs), facilitate the genetic study of recessive traits. In vitro, fish haESCs maintain haploidy in both undifferentiated and differentiated states, but whether mammalian haESCs can preserve pluripotency in the haploid state has not been tested. H...

journal_title：Journal of molecular cell biology

authors： Shuai L,Wang Y,Dong M,Wang X,Sang L,Wang M,Wan H,Luo G,Gu T,Yuan Y,Feng C,Teng F,Li W,Liu X,Li T,Wang L,Wang XJ,Zhao XY,Zhou Q

更新日期：2015-08-01 00:00:00

abstract：:Motile cilia and flagella are microtubule-based organelles important for cell locomotion and extracellular liquid flow through beating. Although axonenal dyneins that drive ciliary beat have been extensively studied in unicellular Chlamydomonas, to what extent such knowledge can be applied to vertebrate is poorly know...

journal_title：Journal of molecular cell biology

authors： Zhang Y,Chen Y,Zheng J,Wang J,Duan S,Zhang W,Yan X,Zhu X

更新日期：2019-05-01 00:00:00

abstract：:Mycobacterium tuberculosis is one of the most notorious killers worldwide. These pathogens have evolved to infect human beings in a so-called dormant form that is extremely difficult to treat. New work, however, suggests that mycobacterial proteasomes, multicomponent structures that protect the microbe from damaging e...

journal_title：Journal of molecular cell biology

authors： Cheng Y,Pieters J

更新日期：2010-08-01 00:00:00

abstract：:HIV-Tat-interacting protein of 60 kDa (TIP60) is a lysine acetyltransferase and known to be downregulated in multiple cancers. Among various signalling pathways, TIP60 is implicated in regulating epithelial-mesenchymal transition (EMT). Here, we show that TIP60 expression abrogates cell migration and metastatic potent...

journal_title：Journal of molecular cell biology

authors： Zhang Y,Subbaiah VK,Rajagopalan D,Tham CY,Abdullah LN,Toh TB,Gong M,Tan TZ,Jadhav SP,Pandey AK,Karnani N,Chow EK,Thiery JP,Jha S

更新日期：2016-10-01 00:00:00

abstract：:The SMYD (SET and MYND domain) family of lysine methyltransferases (KMTs) plays pivotal roles in various cellular processes, including gene expression regulation and DNA damage response. Initially identified as genuine histone methyltransferases, specific members of this family have recently been shown to methylate no...

journal_title：Journal of molecular cell biology

authors： Abu-Farha M,Lanouette S,Elisma F,Tremblay V,Butson J,Figeys D,Couture JF

更新日期：2011-10-01 00:00:00

abstract：:Although genome-wide association studies (GWAS) have successfully identified thousands of genomic loci associated with hundreds of complex traits in the past decade, the debate about such problems as missing heritability and weak interpretability has been appealing for effective computational methods to facilitate the...

journal_title：Journal of molecular cell biology

authors： Wu M,Lin Z,Ma S,Chen T,Jiang R,Wong WH

更新日期：2017-12-01 00:00:00

abstract：:Bacteria and archaea encode members of the large multiple antibiotic resistance regulator (MarR) family of transcriptional regulators. Generally, MarR homologs regulate activity of genes involved in antibiotic resistance, stress responses, virulence or catabolism of aromatic compounds. They constitute a diverse group ...

journal_title：Journal of molecular cell biology

authors： Perera IC,Grove A

更新日期：2010-10-01 00:00:00

abstract：:OspE, a Shigella type III effector binds to integrin-like kinase and enhances cell adhesion to better disseminate and colonize the intestinal epithelium. Because of the existence of OspE orthologues in other enteropathogens such as enteropathogenic Escherichia coli or Salmonella sp., maintenance of cell adhesion appea...

journal_title：Journal of molecular cell biology

authors： Van Nhieu GT,Guignot J

更新日期：2009-12-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is a highly invasive brain tumor with limited therapeutic means and poor prognosis. Recent studies indicate that glioma-initiating cells/glioma stem cells (GICs/GSCs) may be responsible for tumor initiation, infiltration, and recurrence. GICs could aberrantly employ molecular machinery ba...

journal_title：Journal of molecular cell biology

authors： Li Y,Wang W,Wang F,Wu Q,Li W,Zhong X,Tian K,Zeng T,Gao L,Liu Y,Li S,Jiang X,Du G,Zhou Y

更新日期：2017-08-01 00:00:00

abstract：:The ectoderm has the capability to generate epidermis and neuroectoderm and plays imperative roles during the early embryonic development. Our recent study uncovered a region with ectodermal progenitor potential in mouse embryo at embryonic day 7.0 and revealed that Nodal inhibition is essential for its formation. Her...

journal_title：Journal of molecular cell biology

authors： Li L,Song L,Liu C,Chen J,Peng G,Wang R,Liu P,Tang K,Rossant J,Jing N

更新日期：2015-10-01 00:00:00

abstract：:Inactivation of the p53 gene is a key driver of tumorigenesis in various cancer cohorts and types. The quest for a successful p53-based therapy that holds the promise of treating more than half of the cancer population has culminated in extensive knowledge about the role and function of p53 and led to new proposed inn...

journal_title：Journal of molecular cell biology

authors： Aning OA,Cheok CF

更新日期：2019-03-01 00:00:00

abstract：:Dying cells actively attract professional phagocytes by sending out soluble 'find-me' signals. The characterization and identification of the corresponding molecular entities have revealed that 'find-me' signals come in different flavors, including peptides, proteins, lipids and complex structures, such as apoptotic m...

journal_title：Journal of molecular cell biology

authors： Peter C,Wesselborg S,Lauber K

更新日期：2010-04-01 00:00:00

abstract：:X chromosome inactivation and genomic imprinting are two classic epigenetic regulatory processes that cause mono-allelic gene expression. In female mammals, mono-allelic expression of the long non-coding RNA gene X-inactive specific transcript (XIST) is essential for initiation of X chromosome inactivation upon differ...

journal_title：Journal of molecular cell biology

authors： Zhang Y,Wang C,Liu X,Yang Q,Ji H,Yang M,Xu M,Zhou Y,Xie W,Luo Z,Lin C

更新日期：2019-09-19 00:00:00

abstract：:Scaffolding proteins play pivotal roles in the assembly of macromolecular machines such as the spliceosome. The adaptor protein CD2BP2, originally identified as a binding partner of the adhesion molecule CD2, is a pre-spliceosomal assembly factor that utilizes its glycine-tyrosine-phenylalanine (GYF) domain to co-loca...

journal_title：Journal of molecular cell biology

authors： Albert GI,Schell C,Kirschner KM,Schäfer S,Naumann R,Müller A,Kretz O,Kuropka B,Girbig M,Hübner N,Krause E,Scholz H,Huber TB,Knobeloch KP,Freund C

更新日期：2015-10-01 00:00:00

abstract：:Long thought to be the glue responsible for holding sister chromatids together, cohesin has been found to be stickier than previously thought. Recent discoveries point to cohesin having a role in transcription regulation by mediating long-distance intra-chromosomal interactions. ...

journal_title：Journal of molecular cell biology

authors： Díaz-Martínez LA,Yu H

更新日期：2009-12-01 00:00:00

abstract：:For patients with COVID-19 caused by SARS-CoV-2, the damages to multiple organs have been clinically observed. Since most of current investigations for virus-host interaction are based on cell level, there is an urgent demand to probe tissue-specific features associated with SARS-CoV-2 infection. Based on collected pr...

journal_title：Journal of molecular cell biology

authors： Feng L,Yin YY,Liu CH,Xu KR,Li QR,Wu JR,Zeng R

更新日期：2020-07-08 00:00:00

abstract：:Mdm2 is the key negative regulator of the tumour suppressor p53, making it an attractive target for anti-cancer drug design. We recently identified a new role of Mdm2 in gene repression through its direct interaction with several proteins of the polycomb group (PcG) family. PcG proteins form polycomb repressive comple...

journal_title：Journal of molecular cell biology

authors： Wienken M,Moll UM,Dobbelstein M

更新日期：2017-02-01 00:00:00

abstract：:Deregulation of microRNAs (miRNAs) and c-Myc (Myc) contributes to hepatocellular carcinoma (HCC) progression, but how miRNAs and Myc regulate each other in hepatocarcinogenesis is still poorly understood. Using a functional screen, we identified miR-129-5p as a miRNA that inhibits HCC cell growth. miR-129-5p targets t...

journal_title：Journal of molecular cell biology

authors： Han H,Li W,Shen H,Zhang J,Zhu Y,Li Y

更新日期：2016-10-01 00:00:00

abstract：:Type 2 immune response has been shown to facilitate cold-induced thermogenesis and browning of white fat. However, whether alternatively activated macrophages produce catecholamine and substantially promote adaptive thermogenesis in adipose tissue remains controversial. Here, we show that tyrosine hydroxylase (TyrH), ...

journal_title：Journal of molecular cell biology

authors： Luo Y,Liu B,Yang X,Ma X,Zhang X,Bragin DE,Yang XO,Huang W,Liu M

更新日期：2017-10-01 00:00:00

abstract：:Local signaling events at synapses or axon terminals are communicated to the nucleus to elicit transcriptional responses, and thereby translate information about the external environment into internal neuronal representations. This retrograde signaling is critical to dendritic growth, synapse development, and neuronal...

journal_title：Journal of molecular cell biology

authors： Wu Y,Lv X,Wang H,Qian K,Ding J,Wang J,Hua S,Sun T,Zhou Y,Yu L,Qiu S

更新日期：2020-10-26 00:00:00