Abstract:
:Local signaling events at synapses or axon terminals are communicated to the nucleus to elicit transcriptional responses, and thereby translate information about the external environment into internal neuronal representations. This retrograde signaling is critical to dendritic growth, synapse development, and neuronal plasticity. Here, we demonstrate that neuronal activity induces retrograde translocation and nuclear accumulation of endosomal adaptor APPL1. Disrupting the interaction of APPL1 with Importin α1 abolishes nuclear accumulation of APPL1, which in turn decreases the levels of histone acetylation. We further demonstrate that retrograde translocation of APPL1 is required for the regulation of gene transcription and then maintenance of hippocampal late-phase long-term potentiation. Thus, these results illustrate an APPL1-mediated pathway that contributes to the modulation of synaptic plasticity via coupling neuronal activity with chromatin remodeling.
journal_name
J Mol Cell Bioljournal_title
Journal of molecular cell biologyauthors
Wu Y,Lv X,Wang H,Qian K,Ding J,Wang J,Hua S,Sun T,Zhou Y,Yu L,Qiu Sdoi
10.1093/jmcb/mjaa058subject
Has Abstractpub_date
2020-10-26 00:00:00eissn
1674-2788issn
1759-4685pii
5940026pub_type
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