Ectodermal progenitors derived from epiblast stem cells by inhibition of Nodal signaling.

abstract：:We present a computational study of tissue transcriptomic data of 14 cancer types to address: what may drive cancer cell division? Our analyses point to that persistent disruption of the intracellular pH by Fenton reactions may be at the root of cancer development. Specifically, we have statistically demonstrated that...

journal_title：Journal of molecular cell biology

authors： Sun H,Zhang C,Cao S,Sheng T,Dong N,Xu Y

更新日期：2018-10-01 00:00:00

abstract：:Analysis linking directly genomics, neuroimaging phenotypes and clinical measurements is crucial for understanding psychiatric disorders, but remains rare. Here, we describe a multi-scale analysis using genome-wide SNPs, gene expression, grey matter volume (GMV), and the positive and negative syndrome scale scores (PA...

journal_title：Journal of molecular cell biology

authors： Ma L,Rolls ET,Liu X,Liu Y,Jiao Z,Wang Y,Gong W,Ma Z,Gong F,Wan L

更新日期：2019-08-19 00:00:00

abstract：:Breathing is an integrated motor behavior that is driven and controlled by a network of brainstem neurons. Zfhx4 is a zinc finger transcription factor and our results showed that it was specifically expressed in several regions of the mouse brainstem. Mice lacking Zfhx4 died shortly after birth from an apparent inabil...

journal_title：Journal of molecular cell biology

authors： Zhang M,Du S,Ou H,Cui R,Jiang N,Lin Y,Ge R,Ma D,Zhang J

更新日期：2021-01-20 00:00:00

abstract：:As many human sensory and cognitive diseases are caused by irreversible damage or loss of certain types of neurons, methodologies aimed at replacement of lost neurons are key to restore lost sensation. Recent advances in generation of ear-cell progenitors, optic-cup structures and cortical neurons from human embryonic...

journal_title：Journal of molecular cell biology

authors： Zhang K,Yi F,Liu GH,Belmonte JC

更新日期：2013-04-01 00:00:00

abstract：:Establishment of the primordial follicle (PF) pool is pivotal for the female reproductive lifespan; however, the mechanism of primordial folliculogenesis is poorly understood. Here, the transcription factor SP1 was shown to be essential for PF formation in mice. Our results showed that SP1 is present in both oocytes a...

journal_title：Journal of molecular cell biology

authors： Cai H,Liu B,Wang H,Sun G,Feng L,Chen Z,Zhou J,Zhang J,Zhang T,He M,Yang T,Guo Q,Teng Z,Xin Q,Zhou B,Zhang H,Xia G,Wang C

更新日期：2020-04-24 00:00:00

abstract：:Complex immune responses have evolved to protect multicellular organisms against the invasion of pathogens. This has exerted strong developmental pressure for specialized functions that can also limit damage to self-tissue. Two arms of immunity, the innate and adaptive immune systems, have evolved for quick, non-speci...

journal_title：Journal of molecular cell biology

authors： Issazadeh-Navikas S

更新日期：2012-04-01 00:00:00

abstract：:Embryonic stem cells (ESCs) exhibit unique chromatin features, including a permissive transcriptional program and an open, decondensed chromatin state. Induced pluripotent stem cells (iPSCs), which are very similar to ESCs, hold great promise for therapy and basic research. However, the mechanisms by which reprogrammi...

journal_title：Journal of molecular cell biology

authors： Mattout A,Biran A,Meshorer E

更新日期：2011-12-01 00:00:00

abstract：:The involvement of microRNAs (miRNAs) in the development of the neural crest (NC) cells and other neuronal differentiation is still poorly understood. Here, we investigated the global function of miRNAs in embryonic development by examining the Wnt1-cre-mediated Dicer knockout mice. Dicer ablation resulted in malforma...

journal_title：Journal of molecular cell biology

authors： Huang T,Liu Y,Huang M,Zhao X,Cheng L

更新日期：2010-06-01 00:00:00

abstract：:MEK inhibitor has been highlighted as a promising anti-tumor drug but its effect has been reported as varying over a wide range depending on patho-physiological conditions. In this study, we employed a systems approach by combining biochemical experimentation with in silico simulations to investigate the resistance me...

journal_title：Journal of molecular cell biology

authors： Won JK,Yang HW,Shin SY,Lee JH,Heo WD,Cho KH

更新日期：2012-06-01 00:00:00

abstract：:Normal tissues are organized in a hierarchical model, whereas at the apex of these hierarchies reside stem cells (SCs) capable of self-renewal and of producing differentiated cellular progenies, leading to normal development and homeostasis. Alike, tumors are organized in a hierarchical manner, with cancer SCs residin...

journal_title：Journal of molecular cell biology

authors： Koifman G,Aloni-Grinstein R,Rotter V

更新日期：2019-07-19 00:00:00

abstract：:Mycobacterium tuberculosis is one of the most notorious killers worldwide. These pathogens have evolved to infect human beings in a so-called dormant form that is extremely difficult to treat. New work, however, suggests that mycobacterial proteasomes, multicomponent structures that protect the microbe from damaging e...

journal_title：Journal of molecular cell biology

authors： Cheng Y,Pieters J

更新日期：2010-08-01 00:00:00

abstract：:Homoeostatic regulation of the light sensor, rhodopsin, is critical for the maintenance of light sensitivity and survival of photoreceptors. The major fly rhodopsin, Rh1, undergoes light-induced endocytosis and degradation, but its protein and mRNA levels remain constant during light/dark cycles. It is not clear how t...

journal_title：Journal of molecular cell biology

authors： Wang X,Mu Y,Sun M,Han J

更新日期：2017-04-01 00:00:00

abstract：:Bacteria and archaea encode members of the large multiple antibiotic resistance regulator (MarR) family of transcriptional regulators. Generally, MarR homologs regulate activity of genes involved in antibiotic resistance, stress responses, virulence or catabolism of aromatic compounds. They constitute a diverse group ...

journal_title：Journal of molecular cell biology

authors： Perera IC,Grove A

更新日期：2010-10-01 00:00:00

abstract：:Extracellular vesicles (EVs) carry signals within or at their limiting membranes, providing a mechanism by which cells can exchange more complex information than what was previously thought. In addition to mRNAs and microRNAs, there are DNA fragments in EVs. Solexa sequencing indicated the presence of at least 16434 g...

journal_title：Journal of molecular cell biology

authors： Cai J,Han Y,Ren H,Chen C,He D,Zhou L,Eisner GM,Asico LD,Jose PA,Zeng C

更新日期：2013-08-01 00:00:00

abstract：:Ever since gene targeting or specific modification of genome sequences in mice was achieved in the early 1980s, the reverse genetic approach of precise editing of any genomic locus has greatly accelerated biomedical research and biotechnology development. In particular, the recent development of the CRISPR/Cas9 system...

journal_title：Journal of molecular cell biology

authors： Wu Q,Shou J

更新日期：2020-10-30 00:00:00

abstract：:The mouse double minute 4 (MDM4) is emerging from the shadow of its more famous relative MDM2 and is starting to steal the limelight, largely due to its therapeutic possibilities. MDM4 is a vital regulator of the tumor suppressor p53. It restricts p53 transcriptional activity and also, at least in development, facilit...

journal_title：Journal of molecular cell biology

authors： Haupt S,Mejía-Hernández JO,Vijayakumaran R,Keam SP,Haupt Y

更新日期：2019-03-01 00:00:00

abstract：:Although genome-wide association studies (GWAS) have successfully identified thousands of genomic loci associated with hundreds of complex traits in the past decade, the debate about such problems as missing heritability and weak interpretability has been appealing for effective computational methods to facilitate the...

journal_title：Journal of molecular cell biology

authors： Wu M,Lin Z,Ma S,Chen T,Jiang R,Wong WH

更新日期：2017-12-01 00:00:00

abstract：:Mammalian fertilization involves membrane events-adhesion, fusion, sperm engulfment, membrane block to polyspermy-whose causes remain largely unknown. Recently, specific oscillations of the sperm in contact with the egg were shown to be necessary for fusion. Using a microfluidic chip to impose the venue for the encoun...

journal_title：Journal of molecular cell biology

authors： Ravaux B,Favier S,Perez E,Gourier C

更新日期：2018-12-01 00:00:00

abstract：:The MYC transcription factor plays a key role in cell growth control. Enhanced MYC protein stability has been found to promote tumorigenesis. Thus, understanding how MYC stability is controlled may have significant implications for revealing MYC-driven growth regulatory mechanisms in physiological and pathological pro...

journal_title：Journal of molecular cell biology

authors： Gonzalez-Pecchi V,Kwan AK,Doyle S,Ivanov AA,Du Y,Fu H

更新日期：2020-07-03 00:00:00

abstract：:T-cell intracellular antigen (TIA)-1 and TIA-1-related protein (TIAR) are mRNA-binding proteins that can aggregate within granules under specific stress conditions. In this study, we analyzed TIAR/TIA-1 aggregation under different hypoxic conditions, and studied the effects on the hypoxia-inducible factor (HIF)-1α in ...

journal_title：Journal of molecular cell biology

authors： Gottschald OR,Malec V,Krasteva G,Hasan D,Kamlah F,Herold S,Rose F,Seeger W,Hänze J

更新日期：2010-12-01 00:00:00

abstract：:Advances in functional genomics have led to discovery of a large group of previous uncharacterized long non-coding RNAs (lncRNAs). Emerging evidence indicates that lncRNAs may serve as master gene regulators through various mechanisms. Dysregulation of lncRNAs is often associated with a variety of human diseases inclu...

journal_title：Journal of molecular cell biology

authors： Zhang A,Xu M,Mo YY

更新日期：2014-06-01 00:00:00

abstract：:Scaffolding proteins play pivotal roles in the assembly of macromolecular machines such as the spliceosome. The adaptor protein CD2BP2, originally identified as a binding partner of the adhesion molecule CD2, is a pre-spliceosomal assembly factor that utilizes its glycine-tyrosine-phenylalanine (GYF) domain to co-loca...

journal_title：Journal of molecular cell biology

authors： Albert GI,Schell C,Kirschner KM,Schäfer S,Naumann R,Müller A,Kretz O,Kuropka B,Girbig M,Hübner N,Krause E,Scholz H,Huber TB,Knobeloch KP,Freund C

更新日期：2015-10-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC), characterized by the lack of expression of the estrogen receptor, the progesterone receptor, and the human epidermal growth factor receptor 2, is an aggressive form of cancer that conveys unpredictable and poor prognosis due to limited treatment options and lack of effective targe...

journal_title：Journal of molecular cell biology

authors： Liu S,Wang Z,Liu Z,Shi S,Zhang Z,Zhang J,Lin H

更新日期：2018-08-01 00:00:00

abstract：:Long thought to be the glue responsible for holding sister chromatids together, cohesin has been found to be stickier than previously thought. Recent discoveries point to cohesin having a role in transcription regulation by mediating long-distance intra-chromosomal interactions. ...

journal_title：Journal of molecular cell biology

authors： Díaz-Martínez LA,Yu H

更新日期：2009-12-01 00:00:00

abstract：:SRY-related HMG-box gene 2 (SOX2) is one of the key regulatory genes that maintain the pluripotency and self-renewal properties in embryonic stem cells. Here we used immunohistochemistry to analyze the expression of SOX2 in human prostate tissues and found it contributed to tumorigenesis and correlated with histologic...

journal_title：Journal of molecular cell biology

authors： Jia X,Li X,Xu Y,Zhang S,Mou W,Liu Y,Liu Y,Lv D,Liu CH,Tan X,Xiang R,Li N

更新日期：2011-08-01 00:00:00

abstract：:The SMYD (SET and MYND domain) family of lysine methyltransferases (KMTs) plays pivotal roles in various cellular processes, including gene expression regulation and DNA damage response. Initially identified as genuine histone methyltransferases, specific members of this family have recently been shown to methylate no...

journal_title：Journal of molecular cell biology

authors： Abu-Farha M,Lanouette S,Elisma F,Tremblay V,Butson J,Figeys D,Couture JF

更新日期：2011-10-01 00:00:00

abstract：:Although cancer and neurodegenerative disease are two distinct pathological disorders, emerging evidence indicates that these two types of disease share common mechanisms of genetic and molecular abnormalities. Recent studies show that individual microRNAs (miRNAs) could be involved in the pathology of both diseases, ...

journal_title：Journal of molecular cell biology

authors： Du L,Pertsemlidis A

更新日期：2011-06-01 00:00:00

abstract：:Human colon carcinomas (CCs) represent a growing worldwide problem. One of the pathways that has been negatively implicated in the genesis of CCs is triggered by bone morphogenetic protein (BMP) ligands, which activate BMP receptors leading to the function of SMAD proteins in the nucleus. BMP signaling is altered in f...

journal_title：Journal of molecular cell biology

authors： Lorente-Trigos A,Varnat F,Melotti A,Ruiz i Altaba A

更新日期：2010-12-01 00:00:00

abstract：:We previously identified that hepatitis B virus (HBV) encodes a microRNA (HBV-miR-3) that restrains HBV replication by targeting the HBV transcript. However, whether HBV-miR-3 affects host innate immunity to modulate HBV replication remains unclear. Here, we examined the vital functions of HBV-miR-3 in the innate immu...

journal_title：Journal of molecular cell biology

authors： Zhao X,Sun L,Mu T,Yi J,Ma C,Xie H,Liu M,Tang H

更新日期：2020-05-18 00:00:00

abstract：:Dying cells actively attract professional phagocytes by sending out soluble 'find-me' signals. The characterization and identification of the corresponding molecular entities have revealed that 'find-me' signals come in different flavors, including peptides, proteins, lipids and complex structures, such as apoptotic m...

journal_title：Journal of molecular cell biology

authors： Peter C,Wesselborg S,Lauber K

更新日期：2010-04-01 00:00:00