当前位置： SCI文献检索 > Journal of Molecular Cell Biology期刊下所有文献 > Multi-scale analysis of schizophrenia risk genes, brain structure, and clinical symptoms reveals integrative clues for subtyping schizophrenia patients.

Multi-scale analysis of schizophrenia risk genes, brain structure, and clinical symptoms reveals integrative clues for subtyping schizophrenia patients.

Abstract：

:Analysis linking directly genomics, neuroimaging phenotypes and clinical measurements is crucial for understanding psychiatric disorders, but remains rare. Here, we describe a multi-scale analysis using genome-wide SNPs, gene expression, grey matter volume (GMV), and the positive and negative syndrome scale scores (PANSS) to explore the etiology of schizophrenia. With 72 drug-naive schizophrenic first episode patients (FEPs) and 73 matched heathy controls, we identified 108 genes, from schizophrenia risk genes, that correlated significantly with GMV, which are highly co-expressed in the brain during development. Among these 108 candidates, 19 distinct genes were found associated with 16 brain regions referred to as hot clusters (HCs), primarily in the frontal cortex, sensory-motor regions and temporal and parietal regions. The patients were subtyped into three groups with distinguishable PANSS scores by the GMV of the identified HCs. Furthermore, we found that HCs with common GMV among patient groups are related to genes that mostly mapped to pathways relevant to neural signaling, which are associated with the risk for schizophrenia. Our results provide an integrated view of how genetic variants may affect brain structures that lead to distinct disease phenotypes. The method of multi-scale analysis that was described in this research, may help to advance the understanding of the etiology of schizophrenia.

journal_name

J Mol Cell Biol

journal_title

Journal of molecular cell biology

authors

Ma L,Rolls ET,Liu X,Liu Y,Jiao Z,Wang Y,Gong W,Ma Z,Gong F,Wan L

doi

10.1093/jmcb/mjy071

subject

Has Abstract

pub_date

2019-08-19 00:00:00

pages

678-687

issue

8

eissn

1674-2788

issn

1759-4685

pii

5227766

journal_volume

11

pub_type

杂志文章

相关文献

Journal of Molecular Cell Biology文献大全
  • NSD3S stabilizes MYC through hindering its interaction with FBXW7.

    abstract：:The MYC transcription factor plays a key role in cell growth control. Enhanced MYC protein stability has been found to promote tumorigenesis. Thus, understanding how MYC stability is controlled may have significant implications for revealing MYC-driven growth regulatory mechanisms in physiological and pathological pro...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjz098

    authors： Gonzalez-Pecchi V,Kwan AK,Doyle S,Ivanov AA,Du Y,Fu H

    更新日期：2020-07-03 00:00:00

  • Wnt1-cre-mediated conditional loss of Dicer results in malformation of the midbrain and cerebellum and failure of neural crest and dopaminergic differentiation in mice.

    abstract：:The involvement of microRNAs (miRNAs) in the development of the neural crest (NC) cells and other neuronal differentiation is still poorly understood. Here, we investigated the global function of miRNAs in embryonic development by examining the Wnt1-cre-mediated Dicer knockout mice. Dicer ablation resulted in malforma...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjq008

    authors： Huang T,Liu Y,Huang M,Zhao X,Cheng L

    更新日期：2010-06-01 00:00:00

  • Bidirectional regulation of fragile X mental retardation protein phosphorylation controls rhodopsin homoeostasis.

    abstract：:Homoeostatic regulation of the light sensor, rhodopsin, is critical for the maintenance of light sensitivity and survival of photoreceptors. The major fly rhodopsin, Rh1, undergoes light-induced endocytosis and degradation, but its protein and mRNA levels remain constant during light/dark cycles. It is not clear how t...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjw041

    authors： Wang X,Mu Y,Sun M,Han J

    更新日期：2017-04-01 00:00:00

  • Durable pluripotency and haploidy in epiblast stem cells derived from haploid embryonic stem cells in vitro.

    abstract：:Haploid pluripotent stem cells, such as haploid embryonic stem cells (haESCs), facilitate the genetic study of recessive traits. In vitro, fish haESCs maintain haploidy in both undifferentiated and differentiated states, but whether mammalian haESCs can preserve pluripotency in the haploid state has not been tested. H...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjv044

    authors： Shuai L,Wang Y,Dong M,Wang X,Sang L,Wang M,Wan H,Luo G,Gu T,Yuan Y,Feng C,Teng F,Li W,Liu X,Li T,Wang L,Wang XJ,Zhao XY,Zhou Q

    更新日期：2015-08-01 00:00:00

  • When Shigella tells the cell to hang on.

    abstract：:OspE, a Shigella type III effector binds to integrin-like kinase and enhances cell adhesion to better disseminate and colonize the intestinal epithelium. Because of the existence of OspE orthologues in other enteropathogens such as enteropathogenic Escherichia coli or Salmonella sp., maintenance of cell adhesion appea...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjp013

    authors： Van Nhieu GT,Guignot J

    更新日期：2009-12-01 00:00:00

  • Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.

    abstract：:Cells encountering hypoxic stress conserve resources and energy by downregulating the protein synthesis. Here we demonstrate that one mechanism in this response is the translational repression of TOP mRNAs that encode components of the translational apparatus. This mode of regulation involves TSC and Rheb, as knockout...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mju008

    authors： Miloslavski R,Cohen E,Avraham A,Iluz Y,Hayouka Z,Kasir J,Mudhasani R,Jones SN,Cybulski N,Rüegg MA,Larsson O,Gandin V,Rajakumar A,Topisirovic I,Meyuhas O

    更新日期：2014-06-01 00:00:00

  • SP1 governs primordial folliculogenesis by regulating pregranulosa cell development in mice.

    abstract：:Establishment of the primordial follicle (PF) pool is pivotal for the female reproductive lifespan; however, the mechanism of primordial folliculogenesis is poorly understood. Here, the transcription factor SP1 was shown to be essential for PF formation in mice. Our results showed that SP1 is present in both oocytes a...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjz059

    authors： Cai H,Liu B,Wang H,Sun G,Feng L,Chen Z,Zhou J,Zhang J,Zhang T,He M,Yang T,Guo Q,Teng Z,Xin Q,Zhou B,Zhang H,Xia G,Wang C

    更新日期：2020-04-24 00:00:00

  • Cigarette smoke-induced cell cycle arrest in spermatocytes [GC-2spd(ts)] is mediated through crosstalk between Ahr-Nrf2 pathway and MAPK signaling.

    abstract：:Our earlier studies have demonstrated that the cigarette smoke in the form of cigarette smoke condensate (CSC) causes growth arrest of a mouse spermatocyte cell line [GC-2spd(ts)] through activation of the AHR-NRF2 pathway. The present study demonstrates the CSC-activated p38 and ERK MAPK signaling in GC-2spd(ts) via ...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mju049

    authors： Esakky P,Hansen DA,Drury AM,Moley KH

    更新日期：2015-02-01 00:00:00

  • Molecular mechanisms of ligand-mediated attenuation of DNA binding by MarR family transcriptional regulators.

    abstract：:Bacteria and archaea encode members of the large multiple antibiotic resistance regulator (MarR) family of transcriptional regulators. Generally, MarR homologs regulate activity of genes involved in antibiotic resistance, stress responses, virulence or catabolism of aromatic compounds. They constitute a diverse group ...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjq021

    authors： Perera IC,Grove A

    更新日期：2010-10-01 00:00:00

  • Haploinsufficiency of the TDP43 ubiquitin E3 ligase RNF220 leads to ALS-like motor neuron defects in the mouse.

    abstract：:TDP43 pathology is seen in a large majority of amyotrophic lateral sclerosis (ALS) cases, suggesting a central pathogenic role of this regulatory protein. Clarifying the molecular mechanism controlling TDP43 stability and subcellular location might provide important insights into ALS therapy. The ubiquitin E3 ligase R...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjaa072

    authors： Ma P,Li Y,Wang H,Mao B

    更新日期：2021-01-02 00:00:00

  • Paired related homeobox 1 transactivates dopamine D2 receptor to maintain propagation and tumorigenicity of glioma-initiating cells.

    abstract：:Glioblastoma multiforme (GBM) is a highly invasive brain tumor with limited therapeutic means and poor prognosis. Recent studies indicate that glioma-initiating cells/glioma stem cells (GICs/GSCs) may be responsible for tumor initiation, infiltration, and recurrence. GICs could aberrantly employ molecular machinery ba...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjx017

    authors： Li Y,Wang W,Wang F,Wu Q,Li W,Zhong X,Tian K,Zeng T,Gao L,Liu Y,Li S,Jiang X,Du G,Zhou Y

    更新日期：2017-08-01 00:00:00

  • Egg CD9 protein tides correlated with sperm oscillations tune the gamete fusion ability in mammal.

    abstract：:Mammalian fertilization involves membrane events-adhesion, fusion, sperm engulfment, membrane block to polyspermy-whose causes remain largely unknown. Recently, specific oscillations of the sperm in contact with the egg were shown to be necessary for fusion. Using a microfluidic chip to impose the venue for the encoun...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjy005

    authors： Ravaux B,Favier S,Perez E,Gourier C

    更新日期：2018-12-01 00:00:00

  • TIP60 inhibits metastasis by ablating DNMT1-SNAIL2-driven epithelial-mesenchymal transition program.

    abstract：:HIV-Tat-interacting protein of 60 kDa (TIP60) is a lysine acetyltransferase and known to be downregulated in multiple cancers. Among various signalling pathways, TIP60 is implicated in regulating epithelial-mesenchymal transition (EMT). Here, we show that TIP60 expression abrogates cell migration and metastatic potent...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjw038

    authors： Zhang Y,Subbaiah VK,Rajagopalan D,Tham CY,Abdullah LN,Toh TB,Gong M,Tan TZ,Jadhav SP,Pandey AK,Karnani N,Chow EK,Thiery JP,Jha S

    更新日期：2016-10-01 00:00:00

  • Cancer-associated adipocyte-derived G-CSF promotes breast cancer malignancy via Stat3 signaling.

    abstract：:Adipocyte is the most predominant cell type in the tumor microenvironment of breast cancer and plays a pivotal role in cancer progression, yet the underlying mechanisms and functional mediators remain elusive. We isolated primary preadipocytes from mammary fat pads of human breast cancer patients and generated mature ...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjaa016

    authors： Liu L,Wu Y,Zhang C,Zhou C,Li Y,Zeng Y,Zhang C,Li R,Luo D,Wang L,Zhang L,Tu S,Deng H,Luo S,Chen YG,Xiong X,Yan X

    更新日期：2020-09-01 00:00:00

  • Embryonic hematopoiesis in vertebrate somites gives rise to definitive hematopoietic stem cells.

    abstract：:Hematopoietic stem cells (HSCs) replenish all types of blood cells. It is debating whether HSCs in adults solely originate from the aorta-gonad-mesonephros (AGM) region, more specifically, the dorsal aorta, during embryogenesis. Here, we report that somite hematopoiesis, a previously unwitnessed hematopoiesis, can gen...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjw024

    authors： Qiu J,Fan X,Wang Y,Jin H,Song Y,Han Y,Huang S,Meng Y,Tang F,Meng A

    更新日期：2016-08-01 00:00:00

  • Toward precision CRISPR DNA fragment editing and predictable 3D genome engineering.

    abstract：:Ever since gene targeting or specific modification of genome sequences in mice was achieved in the early 1980s, the reverse genetic approach of precise editing of any genomic locus has greatly accelerated biomedical research and biotechnology development. In particular, the recent development of the CRISPR/Cas9 system...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjaa060

    authors： Wu Q,Shou J

    更新日期：2020-10-30 00:00:00

  • Role of the lncRNA-p53 regulatory network in cancer.

    abstract：:Advances in functional genomics have led to discovery of a large group of previous uncharacterized long non-coding RNAs (lncRNAs). Emerging evidence indicates that lncRNAs may serve as master gene regulators through various mechanisms. Dysregulation of lncRNAs is often associated with a variety of human diseases inclu...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章,评审

    doi：10.1093/jmcb/mju013

    authors： Zhang A,Xu M,Mo YY

    更新日期：2014-06-01 00:00:00

  • Mdm2 as a chromatin modifier.

    abstract：:Mdm2 is the key negative regulator of the tumour suppressor p53, making it an attractive target for anti-cancer drug design. We recently identified a new role of Mdm2 in gene repression through its direct interaction with several proteins of the polycomb group (PcG) family. PcG proteins form polycomb repressive comple...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章,评审

    doi：10.1093/jmcb/mjw046

    authors： Wienken M,Moll UM,Dobbelstein M

    更新日期：2017-02-01 00:00:00

  • An HBV-encoded miRNA activates innate immunity to restrict HBV replication.

    abstract：:We previously identified that hepatitis B virus (HBV) encodes a microRNA (HBV-miR-3) that restrains HBV replication by targeting the HBV transcript. However, whether HBV-miR-3 affects host innate immunity to modulate HBV replication remains unclear. Here, we examined the vital functions of HBV-miR-3 in the innate immu...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjz104

    authors： Zhao X,Sun L,Mu T,Yi J,Ma C,Xie H,Liu M,Tang H

    更新日期：2020-05-18 00:00:00

  • Molecular suicide notes: last call from apoptosing cells.

    abstract：:Dying cells actively attract professional phagocytes by sending out soluble 'find-me' signals. The characterization and identification of the corresponding molecular entities have revealed that 'find-me' signals come in different flavors, including peptides, proteins, lipids and complex structures, such as apoptotic m...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjp045

    authors： Peter C,Wesselborg S,Lauber K

    更新日期：2010-04-01 00:00:00

  • mTORC1 signaling: what we still don't know.

    abstract：:The mammalian target of rapamycin (mTOR) is a protein kinase that plays key roles in cellular regulation. It forms complexes with additional proteins. The best-understood one is mTOR complex 1 (mTORC1). The regulation and cellular functions of mTORC1 have been the subjects of intense study; despite this, many question...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章,评审

    doi：10.1093/jmcb/mjq038

    authors： Wang X,Proud CG

    更新日期：2011-08-01 00:00:00

  • microRNA-129-5p, a c-Myc negative target, affects hepatocellular carcinoma progression by blocking the Warburg effect.

    abstract：:Deregulation of microRNAs (miRNAs) and c-Myc (Myc) contributes to hepatocellular carcinoma (HCC) progression, but how miRNAs and Myc regulate each other in hepatocarcinogenesis is still poorly understood. Using a functional screen, we identified miR-129-5p as a miRNA that inhibits HCC cell growth. miR-129-5p targets t...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjw010

    authors： Han H,Li W,Shen H,Zhang J,Zhu Y,Li Y

    更新日期：2016-10-01 00:00:00

  • miR-221/222 activate the Wnt/β-catenin signaling to promote triple-negative breast cancer.

    abstract：:Triple-negative breast cancer (TNBC), characterized by the lack of expression of the estrogen receptor, the progesterone receptor, and the human epidermal growth factor receptor 2, is an aggressive form of cancer that conveys unpredictable and poor prognosis due to limited treatment options and lack of effective targe...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjy041

    authors： Liu S,Wang Z,Liu Z,Shi S,Zhang Z,Zhang J,Lin H

    更新日期：2018-08-01 00:00:00

  • Global epigenetic changes during somatic cell reprogramming to iPS cells.

    abstract：:Embryonic stem cells (ESCs) exhibit unique chromatin features, including a permissive transcriptional program and an open, decondensed chromatin state. Induced pluripotent stem cells (iPSCs), which are very similar to ESCs, hold great promise for therapy and basic research. However, the mechanisms by which reprogrammi...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjr028

    authors： Mattout A,Biran A,Meshorer E

    更新日期：2011-12-01 00:00:00

  • Ectodermal progenitors derived from epiblast stem cells by inhibition of Nodal signaling.

    abstract：:The ectoderm has the capability to generate epidermis and neuroectoderm and plays imperative roles during the early embryonic development. Our recent study uncovered a region with ectodermal progenitor potential in mouse embryo at embryonic day 7.0 and revealed that Nodal inhibition is essential for its formation. Her...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjv030

    authors： Li L,Song L,Liu C,Chen J,Peng G,Wang R,Liu P,Tang K,Rossant J,Jing N

    更新日期：2015-10-01 00:00:00

  • Rheb promotes brown fat thermogenesis by Notch-dependent activation of the PKA signaling pathway.

    abstract：:Increasing brown and beige fat thermogenesis have an anti-obesity effect and thus great metabolic benefits. However, the molecular mechanisms regulating brown and beige fat thermogenesis remain to be further elucidated. We recently found that fat-specific knockout of Rheb promoted beige fat thermogenesis. In the curre...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjz056

    authors： Meng W,Liang X,Xiao T,Wang J,Wen J,Luo H,Teng J,Fei Y,Zhang Q,Liu B,Hu F,Bai J,Liu M,Zhou Z,Liu F

    更新日期：2019-09-19 00:00:00

  • The crossregulation between ERK and PI3K signaling pathways determines the tumoricidal efficacy of MEK inhibitor.

    abstract：:MEK inhibitor has been highlighted as a promising anti-tumor drug but its effect has been reported as varying over a wide range depending on patho-physiological conditions. In this study, we employed a systems approach by combining biochemical experimentation with in silico simulations to investigate the resistance me...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjs021

    authors： Won JK,Yang HW,Shin SY,Lee JH,Heo WD,Cho KH

    更新日期：2012-06-01 00:00:00

  • Vertebrate Dynein-f depends on Wdr78 for axonemal localization and is essential for ciliary beat.

    abstract：:Motile cilia and flagella are microtubule-based organelles important for cell locomotion and extracellular liquid flow through beating. Although axonenal dyneins that drive ciliary beat have been extensively studied in unicellular Chlamydomonas, to what extent such knowledge can be applied to vertebrate is poorly know...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjy043

    authors： Zhang Y,Chen Y,Zheng J,Wang J,Duan S,Zhang W,Yan X,Zhu X

    更新日期：2019-05-01 00:00:00

  • Deregulation of tumor suppressive ASXL1-PTEN/AKT axis in myeloid malignancies.

    abstract：:Mutations of epigenetic regulators are pervasive in human tumors. ASXL1 is frequently mutated in myeloid malignancies. We previously found that ASXL1 forms together with BAP1 a complex that can deubiquitinylate mono-ubiquitinylated lysine 119 on histone H2A (H2AK119ub1), a Polycomb repressive mark. However, a complete...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjaa011

    authors： Cao L,Xia X,Kong Y,Jia F,Yuan B,Li R,Li Q,Wang Y,Cui M,Dai Z,Zheng H,Christensen J,Zhou Y,Wu X

    更新日期：2020-09-01 00:00:00

  • Fenton reactions drive nucleotide and ATP syntheses in cancer.

    abstract：:We present a computational study of tissue transcriptomic data of 14 cancer types to address: what may drive cancer cell division? Our analyses point to that persistent disruption of the intracellular pH by Fenton reactions may be at the root of cancer development. Specifically, we have statistically demonstrated that...

    journal_title：Journal of molecular cell biology

    pub_type： 杂志文章

    doi：10.1093/jmcb/mjy039

    authors： Sun H,Zhang C,Cao S,Sheng T,Dong N,Xu Y

    更新日期：2018-10-01 00:00:00