Abstract:
:Ongoing research on malignant and normal cell biology has substantially enhanced the understanding of the biology of cancer and carcinogenesis. This has led to the development of methods to image the evolution of cancer, target specific biological molecules, and study the anti-tumour effects of novel therapeutic agents. At the same time, there has been a paradigm shift in the field of oncological imaging from purely structural or functional imaging to combined multimodal structure-function approaches that enable the assessment of malignancy from all aspects (including molecular and functional level) in a single examination. The evolving molecular functional imaging using specific molecular targets (especially with combined positron-emission tomography [PET] computed tomography [CT] using 2- [(18)F]-fluoro-2-deoxy-D-glucose [FDG] and other novel PET tracers) has great potential in translational research, giving specific quantitative information with regard to tumour activity, and has been of pivotal importance in diagnoses and therapy tailoring. Furthermore, molecular functional imaging has taken a key place in the present era of translational cancer research, producing an important tool to study and evolve newer receptor-targeted therapies, gene therapies, and in cancer stem cell research, which could form the basis to translate these agents into clinical practice, popularly termed "theranostics". Targeted molecular imaging needs to be developed in close association with biotechnology, information technology, and basic translational scientists for its best utility. This article reviews the current role of molecular functional imaging as one of the main pillars of translational research.
journal_name
Clin Radioljournal_title
Clinical radiologyauthors
Mahajan A,Goh V,Basu S,Vaish R,Weeks AJ,Thakur MH,Cook GJdoi
10.1016/j.crad.2015.06.082subject
Has Abstractpub_date
2015-10-01 00:00:00pages
1060-82issue
10eissn
0009-9260issn
1365-229Xpii
S0009-9260(15)00275-5journal_volume
70pub_type
杂志文章,评审abstract:AIM:To describe a cerebral computed tomography angiography (CTA) technique using a 320-detector CT machine and a small contrast medium volume (35 ml, 15 ml for test bolus). Also, to compare the quality of these images with that of the images acquired using a larger contrast medium volume (90 or 120 ml) and a fixed time...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2013.10.021
更新日期:2014-03-01 00:00:00
abstract::Technical developments have resulted in a great improvement in the quality of magnetic resonance imaging (MRI) of the orbit. With surface coil data acquisition spatial resolution of less than a millimetre can now be achieved, and contrast discrimination is such that the cortex and nucleus of the lens can be distinguis...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(86)80321-x
更新日期:1986-05-01 00:00:00
abstract:AIMS:To describe the optimum conditions for successful free-hand ultrasound guided intervention using an in-vitro experiment. MATERIALS AND METHODS:Optimal free-hand biopsy conditions were determined using targets buried in a purpose-built interventional phantom. The needle/probe distance and probe/phantom surface ang...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1053/crad.2000.0579
更新日期:2001-06-01 00:00:00
abstract:AIMS:PET-CT scans are routinely performed in patients with lung cancer after investigation by chest x-ray (CXR) and CT scan, when these have demonstrated potentially curable disease. If the majority of patients with lung cancer potentially suitable for curative treatment could be identified earlier in the diagnostic pa...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2011.10.032
更新日期:2012-06-01 00:00:00
abstract:AIM:To evaluate patterns of disease and identify factors predicting outcome in patients presenting with recurrent endometrial adenocarcinoma following primary surgery. MATERIALS AND METHODS:A retrospective review was performed of the imaging and clinical data in 86 patients (median age 66 years, range 42-88 years) pre...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2006.06.015
更新日期:2007-01-01 00:00:00
abstract::Needle core biopsy is considered the histological diagnostic method of choice for screen-detected breast lesions. Although the majority are definitively diagnosed as normal, benign, or malignant, approximately 7% are categorised as B3, of uncertain malignant potential. These include a wide range of lesions with differ...
journal_title:Clinical radiology
pub_type: 杂志文章,实务指引
doi:10.1016/j.crad.2018.04.004
更新日期:2018-08-01 00:00:00
abstract:AIM:To determine whether reporting plain films at faster rates lead to a deterioration in accuracy. METHODS:Fourteen consultant radiologists were asked to report a total of 90 radiographs in three sets of 30. They reported the first set at the rate they would report normally and the subsequent two sets in two thirds a...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(03)00289-7
更新日期:2003-12-01 00:00:00
abstract::111Indium (111In) WBC scintigraphy is an accurate method of assessing the extent of inflammatory bowel disease. A prospective study was performed to determine the correlation of ultrasound scanning with 111In WBC scintigraphy in the assessment of inflammatory bowel disease. Eighty-three indium and ultrasound scans wer...
journal_title:Clinical radiology
pub_type: 临床试验,杂志文章
doi:10.1016/s0009-9260(05)80896-7
更新日期:1990-12-01 00:00:00
abstract:AIM:To determine the diagnostic yield of each of three core passes when sampling abnormal lymph nodes in patients presenting with breast cancer. MATERIALS AND METHODS:All patients suspected of having breast cancer had axillary ultrasound as part of initial assessment. Radiologically abnormal nodes (cortical thickness ...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2011.10.006
更新日期:2012-05-01 00:00:00
abstract:AIM:Recent protein expression profiling of breast cancer has identified specific subtypes with clinical, biological, and therapeutic implications. The aim of this study was to identify the mammographic correlates of these novel molecular classes of invasive breast cancer. MATERIALS AND METHODS:The mammographic finding...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2008.06.006
更新日期:2008-11-01 00:00:00
abstract::A patient presenting with upper gastrointestinal bleeding had two visceral angiograms, the second of which demonstrated the hepatic veins in the late phase of the hepatic arterial injection. This observation led to the correct diagnosis of hepatic telangiectasia with arteriovenous shunting and the suspicion, subsequen...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(05)80607-5
更新日期:1990-06-01 00:00:00
abstract::Eighty infants have been treated for neonatal necrotising enterocolitis within a period of five years. Twenty-five per cent developed strictures of the small or large intestine. Four cases of atresia including two with multiple cyst formation were seen. Four patients developed severe malabsorption requiring hyperalime...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(79)80036-7
更新日期:1979-01-01 00:00:00
abstract::Pelvic phleboliths were demonstrated in 1000 subjects aged 16--79 years (mean 42.1, s.d. 12.7). They occurred in 44.2% of the subjects, in 37.3% of the males and 50.1% of the females. Among subjects between the ages of 35 and 54, phleboliths occurred more frequently in the females than in the males. In addition the ol...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(80)80095-x
更新日期:1980-01-01 00:00:00
abstract::The commonest causes of nasal obstruction are rhinitis and chronic rhinosinusitis, which affect up to 30% and 14% of the adult population, respectively. The global financial burden is huge, estimated at $5 billion for rhinitis and $8.6 billion for chronic rhinosinusitis per annum in the USA. On referral for imaging, c...
journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2019.07.027
更新日期:2020-09-01 00:00:00
abstract::The role of ultrasound for the diagnosis of pyloric stenosis has yet to be definitely established. We have carried out 147 ultrasound examinations of 142 infants (99 male and 43 female) with a history of projectile vomiting or the possibility of a pyloric mass. Measurements of the pyloric canal length, transverse pylo...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(05)81849-5
更新日期:1994-04-01 00:00:00
abstract::A randomized prospective trial was undertaken to compare the relative effectiveness of two commonly used bowel preparations (senna tablets and sodium picosulphate powder) administered to patients before they underwent out-patient intravenous urography. Their 'control' films were compared with plain 'kidneys, ureters, ...
journal_title:Clinical radiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0009-9260(05)81271-1
更新日期:1991-11-01 00:00:00
abstract:AIM:To determine the most important cranial ultrasound predictors of abnormality associated with neurodevelopmental outcome at 2 years of age in preterm infants. MATERIALS AND METHODS:A total of 343 preterm infants born between 2005 and 2010 and cared for in KK Women's and Children's Hospital, a tertiary paediatric ho...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2019.11.009
更新日期:2020-04-01 00:00:00
abstract::Skeletal radiological surveys in 161 renal transplant recipients identified 36 patients with 115 lesions of osteonecrosis. A further two patients with osteonecrosis found at autopsy had had no radiographic abnormality. The total incidence of osteonecrosis was, therefore, 38 (24%) out of 161. The lesions were frequentl...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(85)80012-x
更新日期:1985-01-01 00:00:00
abstract::Either radionuclide or contrast venography, or both, were performed in nine patients 2 months to 4 years after insertion of Mobin-Uddin caval umbrella filter for prevention of recurrent pulmonary embolism. In six patients the cava was occluded, and three major groups of collaterals were observed (central, intermediate...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(82)80185-2
更新日期:1982-09-01 00:00:00
abstract:AIM:To evaluate the safety, efficacy, and long-term outcomes of ultrasound-guided radiofrequency ablation (RFA) for the treatment of primary papillary thyroid microcarcinoma (PTMC). MATERIALS AND METHODS:A total of 37 patients with 38 PTMC nodules underwent RFA at a power of 20 W between September 2014 and December 20...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2019.05.012
更新日期:2019-09-01 00:00:00
abstract::Integrated positron-emission tomography and computed tomography (PET/CT) is one of the most important imaging techniques to have emerged in oncological practice in the last decade. Hybrid imaging, in general, remains a rapidly growing field, not only in developing countries, but also in western industrialised healthca...
journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2016.03.013
更新日期:2016-07-01 00:00:00
abstract::Two cases of squamous-cell carcinoma arising in dental cysts are presented. A review of the literature reveals that this is a rare condition and experience of treatment by radiotherapy is limited. The cases reported were controlled locally by external beam megavoltage radiotherapy with no significant long-term morbidi...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(85)80309-3
更新日期:1985-07-01 00:00:00
abstract:AIM:To establish a "one-stop" dysphagia service in which a consultation, barium swallow and endoscopy can all be performed in the same hospital visit. MATERIALS AND METHODS:In order to allow both barium swallow examination and endoscopy to be performed on the same day, a novel technique for clearing barium from the up...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1053/crad.2000.0637
更新日期:2001-01-01 00:00:00
abstract:AIM:To explore the value of CT spectral imaging in the differential diagnosis of necrotic hepatocellular carcinoma (nHCC) and hepatic abscess (HA) during the arterial phase (AP) and portal venous phase (PP). MATERIALS AND METHODS:Sixty patients with 36 nHCCs and 24 HAs underwent spectral CT during AP and PP. Iodine or...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/j.crad.2014.08.018
更新日期:2014-12-01 00:00:00
abstract::Magnetic resonance imaging (MRI), with its superior soft-tissue delineation, plays a pivotal role in the staging and surveillance of cancers affecting adult males, in particular, rectal, urinary bladder, and prostate cancers. There has been much recent interest in the complementary roles of diffusion-weighted imaging ...
journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2012.01.016
更新日期:2012-09-01 00:00:00
abstract::Increasing histological and radiological understanding of the processes involved in soft-tissue injury is leading to novel targeted treatments. A number of reviews have recommended that these treatments should be performed with image guidance. This review describes current ultrasound-guided interventions and injection...
journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2010.09.006
更新日期:2011-02-01 00:00:00
abstract::In presenting five new cases of renal adenomas the authors describe the general nature of these rare tumours. If the small adenoma corresponding to microscopic forms is frequent, the large adenoma is rare and always solitary. Haematuria and pain are the most common signs. The classic criterion of non-malignancy in a s...
journal_title:Clinical radiology
pub_type: 杂志文章
doi:10.1016/s0009-9260(79)80100-2
更新日期:1979-05-01 00:00:00
abstract::A review of imaging in the acquired immune deficiency syndrome (AIDS) is presented. The imaging features can be conveniently categorized according to whether the presenting complications are infective (bacterial, protozoal, or fungal), bronchiectasis, neoplastic (Kaposi's sarcoma, AIDS-related lymphoma, or lymphoproli...
journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/s0009-9260(98)80146-3
更新日期:1998-08-01 00:00:00
abstract::In vivo molecular imaging has a great potential to impact medicine by detecting diseases in early stages (screening), identifying extent of disease, selecting disease- and patient-specific treatment (personalized medicine), applying a directed or targeted therapy, and measuring molecular-specific effects of treatment....
journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2010.03.011
更新日期:2010-07-01 00:00:00
abstract::The radiological findings in paediatric Gaucher disease (GD) are reviewed and future challenges for radiology are discussed. This overview is based on a literature review and our experience of children with GD in one of two national institutions for paediatric GD in the UK. GD is known to progress more rapidly in chil...
journal_title:Clinical radiology
pub_type: 杂志文章,评审
doi:10.1016/j.crad.2003.09.010
更新日期:2004-02-01 00:00:00