Abstract：
AIM:Recent protein expression profiling of breast cancer has identified specific subtypes with clinical, biological, and therapeutic implications. The aim of this study was to identify the mammographic correlates of these novel molecular classes of invasive breast cancer. MATERIALS AND METHODS:The mammographic findings of 415 patients with operable breast cancer were correlated with the previously described protein expression classes identified by our group using immunohistochemical (IHC) assessment of a large series of breast cancer cases prepared as tissue microarrays (TMAs). Twenty-five proteins of known relevance in breast cancer were assessed, including hormone receptors, HER-2 status, basal and luminal markers, p53 expression, and E-cadherin. RESULTS:The mammographic background pattern and proportion of lesions that were mammographically occult were similar in all groups. Groups characterized by luminal and hormone receptor positivity had significantly more spiculate lesions at mammography. Groups characterized by HER-2 overexpression, basal characteristics, and E-cadherin positivity had a significantly higher proportion of ill-defined masses. These findings were independent of histological grade. CONCLUSION:The mammographic features of breast cancer show significant correlation with molecular classes of invasive breast cancer identified by protein expression IHC analysis. The biological reasons for the findings and implications of these regarding imaging protocols require further study and may provide mechanisms for improvement of detection of these lesions.
journal_name
Clin Radioljournal_title
Clinical radiologyauthors
Taneja S,Evans AJ,Rakha EA,Green AR,Ball G,Ellis IOdoi
10.1016/j.crad.2008.06.006subject
Has Abstractpub_date
2008-11-01 00:00:00pages
1228-35issue
11eissn
0009-9260issn
1365-229Xpii
S0009-9260(08)00266-3journal_volume
63pub_type
杂志文章abstract：AIM:To compare the diagnostic performance of the 2017 (v2017) and 2018 versions (v2018) of the Liver Imaging-Reporting and Data System (LI-RADS) for hepatocellular carcinoma (HCC) using gadoxetic acid-enhanced magnetic resonance imaging (Gd-EOB-MRI) and to evaluate the effect in v2018. MATERIALS AND METHODS:Treatment-...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/j.crad.2019.11.004
更新日期：2020-04-01 00:00:00
abstract：AIM:The purpose of the study was to determine the feasibility of three-dimensional (3D) constructive interference in steady state (CISS) sequences for evaluating the anterolateral ligament (ALL). MATERIALS AND METHODS:Magnetic resonance imaging (MRI) of the right knee joint in 30 healthy volunteers was performed using...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/j.crad.2019.08.014
更新日期：2019-12-01 00:00:00
abstract：:Choroidal malignant melanomas are relatively rare tumours and can have a very long natural history. The management of these tumours is controversial. The results of a study of a small group of patients treated by radiotherapy, either as primary treatment or following local excision or enucleation, are presented here. ...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(87)80388-4
更新日期：1987-01-01 00:00:00
abstract：:Computed tomography (CT) proved to be invaluable in diagnosing and ascertaining the extent of an epidermal inclusion cyst of the tympanic membrane secondary to a previous myringoplasty. ...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(05)81168-7
更新日期：1993-03-01 00:00:00
abstract：:Six cases with bacteriologically and/or histologically proven breast tuberculosis were analysed out of 1152 consecutive mammograms performed. The objective was to identify some factors that may facilitate pre-operative mammographic and ultrasonographic diagnosis of breast tuberculosis. Nipple retraction and coarse str...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(96)80115-2
更新日期：1996-05-01 00:00:00
abstract：AIM:To evaluate the early treatment response to chemotherapy in patients with lung cancer using dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI). MATERIALS AND METHODS:Twenty-two patients with lung cancer underwent DCE-MRI before chemotherapy and 1 week after the start of the first course of chemothera...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/j.crad.2018.02.013
更新日期：2018-07-01 00:00:00
abstract：:The first European trial of iodixanol (Nycomed Imaging AS) in adult intravenous urography is reported. Iodixanol is a new non-ionic, dimeric contrast medium of low osmolality. A double-blind, randomized, three group parallel study comparing iodixanol 270 mgI/ml, iodixanol 320 mgI/ml and iopamidol 300 mgI/ml (Niopam) w...
journal_title：Clinical radiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0009-9260(05)81801-x
更新日期：1994-05-01 00:00:00
abstract：AIM:To prospectively analyse the occurrence of right coronary artery (RCA) artefact and assess its relationship with patient heart rate (HR) and HR variability (HRV) in order to determine the most appropriate parameters for high-pitch cardiovascular computed tomography (CT) acquisition, minimize the likelihood of artef...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/j.crad.2014.01.013
更新日期：2014-07-01 00:00:00
abstract：:The ultrasound appearances of primary liver tumour in three patients are described. Changes in these appearances following devascularisation of the tumour by transcatheter embolisation are demonstrated. A possible mechanism for the change in appearances is suggested and is discussed in the light of plain radiographic ...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(80)80028-6
更新日期：1980-11-01 00:00:00
abstract：:The modern management of urolithiasis requires a multi-disciplinary approach. Imaging plays a central role in both diagnosis and planning therapy of renal and ureteric calculi. This article reviews the current status of diagnosis and management of stone disease, and the contribution of radiological imaging in accurate...
journal_title：Clinical radiology
pub_type： 杂志文章,评审
doi：10.1016/s0009-9260(03)00103-x
更新日期：2003-06-01 00:00:00
abstract：AIM:To undertake a meta-analysis of the diagnostic performance of abbreviated (ABB) magnetic resonance imaging (MRI) and full diagnostic protocol MRI (FDP-MRI) in breast cancer. MATERIALS AND METHODS:This meta-analysis was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis for Diagn...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/j.crad.2020.08.036
更新日期：2021-02-01 00:00:00
abstract：:We describe 27 cases of bone tumours or tumour-like lesions where there was spontaneous regression. The follow-up period was 2.8-16.7 years (average, 7.0 years). Fourteen of these cases were no longer visible on plain radiographs. Histological diagnosis included exostosis, eosinophilic granuloma, fibrous dysplasia, fi...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1053/crad.2001.0795
更新日期：2001-11-01 00:00:00
abstract：:Transjugular intrahepatic portosystemic stent shunt (TIPSS) is a new percutaneous technique for reducing portal venous pressure. We attempted TIPSS in six patients with recurrent bleeding for oesophageal or gastric varices between July 1991 and January 1992 with success in five. There have been no deaths. One patient ...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(05)80438-6
更新日期：1992-09-01 00:00:00
abstract：AIM:To investigate the clinical and image features of thymic neuroendocrine tumours (NETs), and characterise the radiological patterns of recurrence and metastasis on serial imaging studies. MATERIALS AND METHODS:The study included 14 patients (11 males) with a histopathological diagnosis of thymic NETs (one typical c...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/j.crad.2017.11.025
更新日期：2018-05-01 00:00:00
abstract：:A review of imaging in the acquired immune deficiency syndrome (AIDS) is presented. The imaging features can be conveniently categorized according to whether the presenting complications are infective (bacterial, protozoal, or fungal), bronchiectasis, neoplastic (Kaposi's sarcoma, AIDS-related lymphoma, or lymphoproli...
journal_title：Clinical radiology
pub_type： 杂志文章,评审
doi：10.1016/s0009-9260(98)80146-3
更新日期：1998-08-01 00:00:00
abstract：:Five patients with deep pelvic abscesses underwent computed tomography (CT)-guided catheter drainage using a transrectal approach. The use of an outer removable plastic sheath over the catheter to facilitate positioning and prevent inadvertent damage to the mucosal wall is described. This new approach using CT guidanc...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(05)80007-8
更新日期：1992-04-01 00:00:00
abstract：AIM:To assess the effect of the presence and locality of symptomatic lower-limb deep vein thrombosis (DVT) on mortality and morbidity following contrast venography (CV), the reference standard for diagnosing below-knee DVT, with a view to determining the prevalence of recurrent episodes of DVT and post-thrombotic syndr...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/j.crad.2015.12.014
更新日期：2016-04-01 00:00:00
abstract：:Fibro-osseous lesions of the bone are well-recognized primary bone tumours. However, given the degree of overlap of imaging findings and variation in management of various sub-types, it is a widely accepted practice to perform a biopsy to obtain histopathological confirmation of the diagnosis. The following is a summa...
journal_title：Clinical radiology
pub_type： 杂志文章,评审
doi：10.1016/j.crad.2013.09.011
更新日期：2014-02-01 00:00:00
abstract：AIM:To evaluate patterns of disease and identify factors predicting outcome in patients presenting with recurrent endometrial adenocarcinoma following primary surgery. MATERIALS AND METHODS:A retrospective review was performed of the imaging and clinical data in 86 patients (median age 66 years, range 42-88 years) pre...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/j.crad.2006.06.015
更新日期：2007-01-01 00:00:00
abstract：AIM:To evaluate the use of a phantom system to help teach the basic techniques of accurate CT-guided needle placement, thereby avoiding the risks associated with teaching on patients. MATERIALS AND METHODS:Gelatine phantoms with five, 1.9 cm embedded spherical wooden targets were constructed. Four trainee operators pe...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/j.crad.2006.09.010
更新日期：2007-02-01 00:00:00
abstract：:In a prospective study, A mode ultrasound scanning contributed to the diagnosis and management of 24 of 50 consecutive patients with pleural disease. In 30% of patients it was superior to radiology in clarifying the solid or fluid nature of a pleural opacity, and in 42% of patients it allowed selection of the most app...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(81)80042-6
更新日期：1981-05-01 00:00:00
abstract：AIMS:PET-CT scans are routinely performed in patients with lung cancer after investigation by chest x-ray (CXR) and CT scan, when these have demonstrated potentially curable disease. If the majority of patients with lung cancer potentially suitable for curative treatment could be identified earlier in the diagnostic pa...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/j.crad.2011.10.032
更新日期：2012-06-01 00:00:00
abstract：:The aim of this study was to document the appearances of fistula-in-ano on magnetic resonance imaging (MRI) and to prospectively evaluate the accuracy of MRI in the pre-operative assessment of anal fistulae. Patients with a clinical diagnosis of fistula-in-ano and awaiting surgery (n = 35) were examined with MRI. The ...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(05)82906-x
更新日期：1994-01-01 00:00:00
abstract：PURPOSE:To determine pre-operative MRI accuracy in assessing local disease extent in recurrent/residual pelvic bowel cancer by comparing MRI assessment and staging examination under anaesthesia (EUA), with laparotomy/histopathological findings. MATERIALS AND METHODS:Twenty-seven consecutive patients with recurrent (n ...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1053/crad.2002.0933
更新日期：2002-06-01 00:00:00
abstract：:We reviewed our experience of the therapeutic role of radiology in Budd-Chiari syndrome. Patients with stenosis and/or occlusion of the main hepatic veins and/or inferior vena cava (IVC) are suitable for radiological intervention (35% in our series). Eighteen patients (mean age 37.4 years) have undergone radiological ...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(96)80005-5
更新日期：1996-11-01 00:00:00
abstract：:Surgical anastomosis between branches of the external and internal carotid arteries may be beneficial in selected cases of transient ischaemic attacks and reversible ischaemic neurological deficit. It is the responsibility of the radiologist, at the time of initial angiographic evaluation, to recognise patients who mi...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(79)80197-x
更新日期：1979-09-01 00:00:00
abstract：AIM:To audit the feasibility and use of diffusion-weighted (DW) magnetic resonance imaging (MRI) as initial neuroimaging for in-patients with clinically suspected acute stroke. MATERIALS AND METHODS:In April 2000, MRI with DW and T2-weighted sequence was locally instituted as initial neuroimaging for patients with cli...
journal_title：Clinical radiology
pub_type： 杂志文章
doi：10.1016/s0009-9260(02)00463-4
更新日期：2003-03-01 00:00:00
abstract：:Intestinal failure (IF) is the inability of the alimentary tract to digest and absorb sufficient nutrition to maintain normal fluid balance, growth, and health. It commonly arises from disease affecting the mesenteric root. Although severe IF is usually managed in specialized units, it lies at the end of a spectrum wi...
journal_title：Clinical radiology
pub_type： 杂志文章,评审
doi：10.1016/j.crad.2010.01.011
更新日期：2010-05-01 00:00:00
abstract：:Integrated positron-emission tomography and computed tomography (PET/CT) is one of the most important imaging techniques to have emerged in oncological practice in the last decade. Hybrid imaging, in general, remains a rapidly growing field, not only in developing countries, but also in western industrialised healthca...
journal_title：Clinical radiology
pub_type： 杂志文章,评审
doi：10.1016/j.crad.2016.03.013
更新日期：2016-07-01 00:00:00
abstract：:This article presents an updated review of cystic renal mass imaging. Most cystic renal masses encountered incidentally are benign and can be diagnosed confidently on imaging and require no follow-up. Hyperattenuating masses discovered at unenhanced or single-phase enhanced computed tomography (CT) measuring between 2...
journal_title：Clinical radiology
pub_type： 杂志文章,评审
doi：10.1016/j.crad.2018.09.003
更新日期：2019-02-01 00:00:00
