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Inhibition of palatal fusion in vitro by indomethacin in two strains of mice with different H-2 backgrounds.

Abstract：

:Susceptibility to glucocorticoid-induced cleft palate in mice has been related to the H-2 histocompatibility complex on chromosome 17. Indomethacin administered in vitro to palatal processes from 13.5-day-old mouse embryos inhibited palatal fusion. Strains with the A background and the H-2a haplotype had significantly higher rates of inhibition than their partners with the H-2b haplotype. The inhibition was prevented in both strains by the addition to the media of prostaglandin E2, but this corrective effect was greater in the A strain with the H-2a haplotype. Thus, blockade of palatal fusion involves prostaglandins, suggesting a similar genetic and biochemical pathway for the different susceptibilities to cleft palate induced by both indomethacin and glucocorticoids.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Montenegro MA,Palomino H

doi

10.1016/0003-9969(89)90051-4

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

949-55

issue

12

eissn

0003-9969

issn

1879-1506

journal_volume

34

pub_type

杂志文章

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