Abstract：
:I would like to stress that there seem to be three subpopulations of neural crest-derived melanocytes in the body that can be functionally and morphologically distinguished: the cutaneous melanocytes, which continuously synthesize small melanosomes to be transferred to keratinocytes; the uveal melanocytes, which synthesize larger melanosomes for only a short while to be retained by this melanogenically dormant cell; and the hair melanocyte, which intermittently produces melanin either in a cyclic manner or as a periodic supply from a stem population. These three types of melanocytes synthesize melanin granules by an identical bipartite system. However, the control mechanism regulating the specific differentiation and postmelanin synthesis function of these cell types needs to be addressed in future research.
journal_name
Dermatol Clinjournal_title
Dermatologic clinicsauthors
Boissy REsubject
Has Abstractpub_date
1988-04-01 00:00:00pages
161-73issue
2eissn
0733-8635issn
1558-0520journal_volume
6pub_type
杂志文章,评审abstract：:UV erythema or sunburn is a common sequela of modern man's pursuit of leisure activities. The dermatologist is frequently confronted with this painful cutaneous inflammatory response. The pathogenesis of sunburn is examined in terms of individual genetic sensitivity, environmental exposure, spectral variability, and t...
journal_title：Dermatologic clinics
pub_type： 杂志文章
doi：
更新日期：1986-04-01 00:00:00
abstract：:Pemphigoid gestationis is a rare, autoimmune bullous disease of pregnancy that involves autoantibodies directed against type XVII collagen in the basement membrane zone. This article discusses the immunopathogenesis, diagnostic methods, and clinical features of this fascinating disease. ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2011.03.002
更新日期：2011-07-01 00:00:00
abstract：:Pediatric allergic contact dermatitis (Ped-ACD) is an increasingly recognized highly prevalent skin disease that has a significant impact on the quality of life of patients and their families. Accurate and appropriate patch testing is vital to diagnosing Ped-ACD. This requires knowledge of the most common allergens in...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2020.02.003
更新日期：2020-07-01 00:00:00
abstract：:Melanoma vaccines represent a novel and potentially effective method of slowing the progression of melanoma. This article discusses the importance in the design of vaccines for melanoma, the relative advantages and disadvantages of this approach, and summarizes the results of the most important clinical trials conduct...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8635(05)70009-7
更新日期：1998-04-01 00:00:00
abstract：:The sensitizing capacity of double-headed haptens containing the pyrocatechol and alpha-methylene-gamma-butyrolactone groups reveals that only the pyrocatechol end is recognized as a sensitizer. Prior sensitization to the double-headed hapten provides protection against (induces immune tolerance to) further sensitizat...
journal_title：Dermatologic clinics
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Solitary pink lesions can pose a particular challenge to dermatologists because they may be almost or completely featureless clinically and dermoscopically, previously requiring biopsy to exclude malignancy. However, these lesions usually are not particularly challenging histopathologically. Thus, the incorporation of...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2016.05.007
更新日期：2016-10-01 00:00:00
abstract：:Skin disease is highly prevalent in the United States, and it has been well-documented that patients with skin disease experience financial, psychological, social, and quality-of-life (QoL) burdens beyond those of the general population. Pediatric patients and their caregivers are particularly vulnerable to the burden...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2012.12.010
更新日期：2013-04-01 00:00:00
abstract：:The success of the Mohs procedure depends on the reliability of each step in the technique. Pitfalls in histologic preparation of the tissue specimens may occur during debulking, excising, orienting, creating the map, sectioning, inking, tissue flattening and freezing, cutting, slide fixation, staining, and mapping th...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2011.01.002
更新日期：2011-04-01 00:00:00
abstract：:This article is a tribute to clinician Henry M. Lewis. The author shares practical therapeutic pearls developed and used over the years by Dr. Lewis. ...
journal_title：Dermatologic clinics
pub_type： 传,历史文章,杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Granuloma formation is usually regarded as a means of defending the host from persistent irritants of either exogenous or endogenous origin. Noninfectious granulomatous disorders of the skin encompass a challenging group of diseases owing to their clinical and histologic overlap. Drug reactions characterized by a gran...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2015.03.015
更新日期：2015-07-01 00:00:00
abstract：:The anatomic region influences the dermoscopic features of different lesions. In this article, the particular characteristics of the scalp, mucosal membranes, and lesions located on the milk line are explained. In histopathology, the benign melanocytic lesions in these locations are also named nevi of special sites, c...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2013.07.003
更新日期：2013-10-01 00:00:00
abstract：:Skin cancer is reaching epidemic levels in the United States. Recent advances in the understanding of the pathophysiology of melanoma have allowed improved risk stratification in the revised American Joint Committee on Cancer (AJCC) criteria, new tests to capture patients at higher risk than their stage may indicate, ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2018.08.003
更新日期：2019-01-01 00:00:00
abstract：:Antimalarial compounds have been demonstrated to be both safe and efficacious in the treatment of lupus erythematosus as well as several other dermatologic conditions. It is imperative, however, that physicians familiarize themselves with the potential complications associated with the use of these agents. Furthermore...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1992-07-01 00:00:00
abstract：:Occupational contact dermatitis in hairdressers is a common clinical dermatologic problem. Apparently often secondary to irritant contact dermatitis caused by shampooing in Europe, in North America, allergic contact dermatitis related to the chemicals handled, especially oxidation dyes and permanent waving components,...
journal_title：Dermatologic clinics
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Normal and malignant pigment cells are known targets for many hormones. Besides alpha-melanocyte-stimulating hormone and the steroidal hormones estrogen, testosterone, and glucocorticoids, factors produced by other epidermal cells can affect melanization and proliferation of pigment cells. Among those factors are the ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1988-04-01 00:00:00
abstract：:Light therapy is widely used in dermatology. An enhancement to his therapy is the use of a photosensitizing medication along with light therapy, known as photodynamic therapy (PDT). PDT is primarily used for the treatment of precancerous lesions, acne vulgaris, and nonmelonoma skin cancer, and has also been shown to i...
journal_title：Dermatologic clinics
pub_type： 杂志文章
doi：10.1016/j.det.2006.09.010
更新日期：2007-01-01 00:00:00
abstract：:Rothmund-Thomson syndrome is a rare inherited disorder characterized by poikilodermatous skin changes that appear in infancy. The inheritance is autosomal recessive. Patients exhibit variable features including skeletal abnormalities, juvenile cataracts, and a higher-than-expected incidence of malignancy. This article...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1995-01-01 00:00:00
abstract：:It is quite evident the pathogenesis of psoriasis is modulated by immune-mediated mechanisms that invoke activated T cells and inflammatory cytokines, such as tumor necrosis factor-alpha. Current immunosuppressive systemic treatments may be effective in controlling psoriasis to a certain degree but have significant dr...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2003.12.002
更新日期：2004-10-01 00:00:00
abstract：:A discussion of the pathologic findings found with aging and photodamage is used to formulate a rational preoperative regimen, treatment technique, and maintenance regimen. Details of laser treatment technique, anesthesia, and postoperative care are given. Possible contraindications are discussed, as are the pros and ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8635(05)70452-6
更新日期：1997-07-01 00:00:00
abstract：:Large defects may at first appear to be too big to close in a side-to-side fashion. Certain wounds and situations may call for healing with second intent. Undermining and pulley sutures are very helpful in bringing together wound edges of certain large openings. Partial closures may decrease the tendency to exert unwa...
journal_title：Dermatologic clinics
pub_type： 杂志文章
doi：10.1016/s0733-8635(05)70294-1
更新日期：2001-07-01 00:00:00
abstract：:Hepatic itch remains among the most agonizing symptoms for affected patients and a major clinical challenge for physicians. Pruritus may occur in almost all liver diseases, particularly those with cholestatic features. Hepatic itch arises irrespective of the severity of the underlying liver disease or extent of choles...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2018.02.008
更新日期：2018-07-01 00:00:00
abstract：:Photoprotection as it pertains to hair is not a common topic addressed by the dermatologist. Hair is nonliving and requires no protection from ultraviolet (UV) radiation because carcinogenesis of the hair shaft itself is not possible. If hair proteins are altered by sun exposure, damaged hair can be removed and replac...
journal_title：Dermatologic clinics
pub_type： 杂志文章
doi：10.1016/j.det.2005.08.006
更新日期：2006-01-01 00:00:00
abstract：:Vasculitis may be defined as damage to blood vessels induced by pathologic processes, resulting in compromise of function of the organ in which the blood vessels reside. A large number of syndromes and disease processes exist in which vasculitis plays a key role. Selected vasculitic syndromes of special interest to de...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1990-10-01 00:00:00
abstract：:Exanthematous eruptions, urticaria, photosensitivity, pigmentary problems, acne, alopecia, fixed drug eruptions, and lichenoid reactions are the most common dermatologic side effects associated with the administration of psychopharmacologic agents. The cutaneous findings associated with the various eruptions and the m...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8635(05)70378-8
更新日期：1996-07-01 00:00:00
abstract：:Medical spas are the fasting growing segment of the 15-billion dollar spa industry. Although medical spas have been in existence since ancient times to treat a wide variety of ailments such as gout, arthritis, and diabetes, our modern concept of the medical spa combines relaxation with medical rejuvenative procedures....
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2008.03.003
更新日期：2008-07-01 00:00:00
abstract：:Infections by VZV, the virus that causes chickenpox and herpes zoster, usually are diagnosed by the classic clinical presentations. In immunocompromised patients, however, the atypical presentation can make the diagnosis more challenging. Although varicella typically follows an uncomplicated course in children, adults...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8635(01)00012-2
更新日期：2002-04-01 00:00:00
abstract：:For both NF and Albright's syndrome, the pathogenetic relationships between the various elements of the respective syndromes remain a mystery, and the importance of nontumorous endocrine abnormalities in neurofibromatosis has, in my opinion, been overstated. Nonetheless, the parallel between the two disorders is strik...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1987-01-01 00:00:00
abstract：:Systemic drugs or ingestants may affect the nails. Changes vary from asymptomatic growth rate changes and pigmentation abnormalities to nail shedding and permanent deformity. The former two changes are most common. Presented are changes in nails caused by antibiotics, cancer chemotherapeutic drugs, poisons and ingesta...
journal_title：Dermatologic clinics
pub_type： 杂志文章
doi：
更新日期：1985-07-01 00:00:00
abstract：:The carcinoid syndrome and its clinical manifestations have been discussed. The standard laboratory test for making that diagnosis is urinary 5-HIAA levels but newer, more sensitive tests may also be available. ...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-01 00:00:00
abstract：:In all forms of epidermolysis bullosa (EB), skin fragility may result in bacterial colonization or infection, particularly in the more severe forms where wounds may be multiple and long-standing. A balance exists between a wound's bacterial load and the host defenses, such that there is a spectrum from simple contamin...
journal_title：Dermatologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.det.2010.01.004
更新日期：2010-04-01 00:00:00
