Abstract:
:Normal and malignant pigment cells are known targets for many hormones. Besides alpha-melanocyte-stimulating hormone and the steroidal hormones estrogen, testosterone, and glucocorticoids, factors produced by other epidermal cells can affect melanization and proliferation of pigment cells. Among those factors are the prostaglandins, vitamin D3, ETAF, and interleukin-1.
journal_name
Dermatol Clinjournal_title
Dermatologic clinicsauthors
Abdel-Malek ZAsubject
Has Abstractpub_date
1988-04-01 00:00:00pages
175-83issue
2eissn
0733-8635issn
1558-0520journal_volume
6pub_type
杂志文章,评审abstract::Cosmeceuticals are understood to be active cosmetics that are sold over-the-counter, but have profound effects on skin appearance and functioning. This term has no legal meaning in the United States, because only cosmetics and pharmaceuticals are recognized by regulatory bodies. Cosmeceuticals are carefully developed ...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/j.det.2013.12.002
更新日期:2014-04-01 00:00:00
abstract::Melanocytic nevi represent benign clonal proliferations of the melanocytes in the skin that usually remain stable in size and behavior or disappear during life. Infrequently, melanocytic nevi undergo malignant transformation to melanoma. Understanding molecular and cellular mechanisms underlying oncogene-induced senes...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/j.det.2016.08.001
更新日期:2017-01-01 00:00:00
abstract::Much progress has been made over the past 10 years with regard to development of a vaccine active against HPV. Successful protection has been achieved in animal models using species-specific papillomaviruses; however, HPV diversity may delay the development of successful HPV vaccines, especially those designed as ther...
journal_title:Dermatologic clinics
pub_type: 杂志文章
doi:10.1016/s0733-8635(05)70056-5
更新日期:1998-10-01 00:00:00
abstract::Excising cancer in successive layers and examining the entire underside of each layer in the microscope by the systematic use of frozen sections ensure eradication of the neoplasm, including its "silent" outgrowths, and this is accomplished with the maximal sparing of normal tissue. Fresh-tissue micrographic surgery i...
journal_title:Dermatologic clinics
pub_type: 历史文章,杂志文章
doi:
更新日期:1989-10-01 00:00:00
abstract::Skin disease is highly prevalent in the United States, and it has been well-documented that patients with skin disease experience financial, psychological, social, and quality-of-life (QoL) burdens beyond those of the general population. Pediatric patients and their caregivers are particularly vulnerable to the burden...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/j.det.2012.12.010
更新日期:2013-04-01 00:00:00
abstract::There have been many advances during the past few years relating to the treatment of superficial fungal infections. This article focuses on recent developments, particularly in oral therapy, but in topical therapy as well. First, the newer agents (especially fluconazole, itraconazole, and terbinafine) are reviewed, an...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/s0733-8635(05)70337-5
更新日期:1996-01-01 00:00:00
abstract::Chloracne is a rare but important acneiform eruption often associated with the ingestion of chlorinated phenolic agents such as dioxins with subsequent toxicity from these chemicals. Clinically, chloracne can be distinguished from acne vulgaris by the distribution and appearance of the lesions and by taking a detailed...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:
更新日期:1990-01-01 00:00:00
abstract::This article describes that the diagnosis of melanoma has improved with such tools as epiluminescence microscopy. There remain, however, a number of unusual types of melanoma that are difficult to diagnose by virtue of their atypical or subtle morphology. The prognosis of these melanomas is often worse than for their ...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/s0733-8635(02)00036-0
更新日期:2002-10-01 00:00:00
abstract::Understanding the anatomy and distribution of facial fat and the alterations that occur during the aging process is essential to effectively and precisely achieve facial rejuvenation. Over the past several years, through cadaveric dissections and computed tomographic studies, much has been discovered concerning the ad...
journal_title:Dermatologic clinics
pub_type: 杂志文章
doi:10.1016/j.det.2013.09.007
更新日期:2014-01-01 00:00:00
abstract::Dermatologists helped to develop the specialty of liposuction surgery and contributed to many of the innovations and instrumentation in this field. Dermatologists were trained side by side with other cosmetic surgeons as the procedure was introduced into the United States. Dermatologists have been important in teachin...
journal_title:Dermatologic clinics
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
abstract::Cutaneous T-cell lymphoma is a malignancy of skin-homing T cells. This unique population of lymphocytes requires alternative therapies to those used in nodal lymphomas. Although phototherapy and nitrogen mustard have been standard treatments for decades, newer therapies have been arriving with increased frequency. Mor...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/j.det.2010.03.010
更新日期:2010-07-01 00:00:00
abstract::This article has shown that all the necessary components for successful control of gonorrhea are available. In developed countries, general improvements in economic conditions and advances in treatment and diagnosis have resulted in the lowest incidence rates of gonorrhea ever. Within these countries, however, control...
journal_title:Dermatologic clinics
pub_type: 杂志文章
doi:10.1016/s0733-8635(05)70036-x
更新日期:1998-10-01 00:00:00
abstract::Black patients who desire cosmetic surgery have not had many treatment options or services available to them. At this time, the requests for specific cosmetic surgical procedures by black patients have far exceeded the number of cosmetic surgeons able to meet their needs. A surgeon who calls himself or herself a cosme...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:
更新日期:1988-07-01 00:00:00
abstract::The therapeutic approach to mucous membrane pemphigoid is site specific, with the goal of preserving function for patients with chronic and treatment-resistant disease. The involvement of certain mucosal sites (ie, ocular, laryngeal, esophageal, nasopharyngeal, and anogenital) is high risk and warrants more aggressive...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/j.det.2011.06.022
更新日期:2011-10-01 00:00:00
abstract::Hair transplantation has developed into a refined art in the past 30 years. Refined techniques and instruments, appreciation of properly placed hairlines, better methods of harvesting donor grafts, and better cutting materials in punches have significantly improved results in one of the most frequently performed cosme...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:
更新日期:1987-07-01 00:00:00
abstract::Ocular melanomas are the most common intraocular malignancy in adults. The majority of ocular melanomas are choroidal melanomas. These tumors can be difficult to diagnose, especially when they are small. Documented growth of a lesion on serial examinations is the most important clinical feature favoring the diagnosis ...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:
更新日期:1992-10-01 00:00:00
abstract::Gardner's syndrome is an autosomal dominant genodermatosis. Familial polyposis of the colon, osteomas, and cutaneous epidermoid cysts are characteristic features. Colon cancer will develop in all affected individuals unless prophylactic colectomy is performed. The follow-up and management of patients with Gardner's sy...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:
更新日期:1995-01-01 00:00:00
abstract::Photoprotection as it pertains to hair is not a common topic addressed by the dermatologist. Hair is nonliving and requires no protection from ultraviolet (UV) radiation because carcinogenesis of the hair shaft itself is not possible. If hair proteins are altered by sun exposure, damaged hair can be removed and replac...
journal_title:Dermatologic clinics
pub_type: 杂志文章
doi:10.1016/j.det.2005.08.006
更新日期:2006-01-01 00:00:00
abstract::Treating the underlying pathophysiology of the wound remains of utmost importance. Several new treatment modalities may soon be available as adjunctive treatments. The efficacy of some remains to be established in well-controlled clinical studies. ...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/s0733-8635(05)70414-9
更新日期:1997-01-01 00:00:00
abstract::In this article, practical and clinical aspects of photoprotection are discussed with emphasis on topical sunscreens. Protection against the adverse effects of sunlight includes prevention of the following: sunburn in normal individuals; acute phototoxic and photoallergic reactions; chronic skin damage (dermatoheliosi...
journal_title:Dermatologic clinics
pub_type: 杂志文章
doi:
更新日期:1986-04-01 00:00:00
abstract::This article reviews the recent dermatopathology literature involving nonmelanocytic neoplasia, with a focus on important work done over the last 5 years. The discussion includes advances in the understanding of Merkel cell carcinoma pathogenesis and prognosis; changes in the seventh edition of the American Joint Comm...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/j.det.2012.06.009
更新日期:2012-10-01 00:00:00
abstract::Photodynamic therapy (PDT) has had a rapid insurgence into the dermatologic armamentarium of clinicians from all over the world. Its use in actinic keratoses and in non-melanoma skin cancers is well described. Additional uses, including its use in the treatment of photorejuvenation and acne vulgaris and related disord...
journal_title:Dermatologic clinics
pub_type: 杂志文章
doi:10.1016/j.det.2006.09.013
更新日期:2007-01-01 00:00:00
abstract::The development and use of various laser systems for the treatment of carcinomas of the skin constitute a relatively new therapeutic approach. Because the skin is a readily accessible organ, it is an excellent site at which to attempt different therapeutic modalities. What is truly astounding has been the development ...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:
更新日期:1991-10-01 00:00:00
abstract::Occupational contact dermatitis in hairdressers is a common clinical dermatologic problem. Apparently often secondary to irritant contact dermatitis caused by shampooing in Europe, in North America, allergic contact dermatitis related to the chemicals handled, especially oxidation dyes and permanent waving components,...
journal_title:Dermatologic clinics
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::Exanthematous eruptions, urticaria, photosensitivity, pigmentary problems, acne, alopecia, fixed drug eruptions, and lichenoid reactions are the most common dermatologic side effects associated with the administration of psychopharmacologic agents. The cutaneous findings associated with the various eruptions and the m...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/s0733-8635(05)70378-8
更新日期:1996-07-01 00:00:00
abstract::There is a spectrum of melanocytic tumors from benign to malignant. The goal of the dermatologist is to identify and remove early melanomas because doing so can be lifesaving. At the same time, it is inappropriate to randomly remove benign nevi. Dermatoscopy is an additional tool that can be used to help discriminate ...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/s0733-8635(05)70269-2
更新日期:2001-04-01 00:00:00
abstract::Liposuction is the most popular cosmetic surgical procedure performed in men. Aside from traditional liposuction using the tumescent technique, several energy-assisted liposuction technologies have emerged and been proven safe and particularly beneficial for the male patient demographic. The differences in fat distrib...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/j.det.2017.09.010
更新日期:2018-01-01 00:00:00
abstract::Alopecia areata (AA) is a recurrent autoimmune type of hair loss that affects about 5.3 million people in the United States alone. Despite being the most prevalent autoimmune disease, the molecular and cellular mechanisms underlying this complex disease are still poorly understood, and rational treatments are lacking....
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/j.det.2012.08.014
更新日期:2013-01-01 00:00:00
abstract::A compendium of uncommon dermatologic treatments, both medical and surgical, are presented. This article is based on a survey of the members of the Noah Worcester Dermatologic Society with subsequent additions, including treatment pearls from the Internet and other contributions from practicing dermatologists, as well...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/s0733-8635(05)70179-0
更新日期:2000-04-01 00:00:00
abstract::Stress is an abnormal or extreme adjustment in the physiology of an animal to cope with adverse effects of its environment and management. The adverse effect is designated the stressor. In this article, the authors try to focus on the main types of host factors that can influence stress (genetics, perception) and on t...
journal_title:Dermatologic clinics
pub_type: 杂志文章,评审
doi:10.1016/s0733-8635(05)70368-5
更新日期:1996-07-01 00:00:00