Management of Chronic Hepatic Itch.

Abstract:

:Hepatic itch remains among the most agonizing symptoms for affected patients and a major clinical challenge for physicians. Pruritus may occur in almost all liver diseases, particularly those with cholestatic features. Hepatic itch arises irrespective of the severity of the underlying liver disease or extent of cholestasis. Antihistamines are ineffective in hepatic itch. Therapeutic recommendations consist of a guideline-based stepwise approach, starting with the anion exchange resin cholestyramine, followed by rifampicin, naltrexone, and sertraline. Bezafibrate and ileal bile acid transporter inhibitors are promising future treatment options. Experimental and invasive procedures should be reserved for refractory pruritus.

journal_name

Dermatol Clin

journal_title

Dermatologic clinics

authors

Düll MM,Kremer AE

doi

10.1016/j.det.2018.02.008

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

293-300

issue

3

eissn

0733-8635

issn

1558-0520

pii

S0733-8635(18)30019-6

journal_volume

36

pub_type

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