Allopregnanolone and perampanel as adjuncts to midazolam for treating diisopropylfluorophosphate-induced status epilepticus in rats.

Abstract:

:Combinations of midazolam, allopregnanolone, and perampanel were assessed for antiseizure activity in a rat diisopropylfluorophosphate (DFP) status epilepticus model. Animals receiving DFP followed by atropine and pralidoxime exhibited continuous high-amplitude rhythmical electroencephalography (EEG) spike activity and behavioral seizures for more than 5 hours. Treatments were administered intramuscularly 40 min after DFP. Seizures persisted following midazolam (1.8 mg/kg). The combination of midazolam with either allopregnanolone (6 mg/kg) or perampanel (2 mg/kg) terminated EEG and behavioral status epilepticus, but the onset of the perampanel effect was slow. The combination of midazolam, allopregnanolone, and perampanel caused rapid and complete suppression of EEG and behavioral seizures. In the absence of DFP, animals treated with the three-drug combination were sedated but not anesthetized. Animals that received midazolam alone exhibited spontaneous recurrent EEG seizures, whereas those that received the three-drug combination did not, demonstrating antiepileptogenic activity. All combination treatments reduced neurodegeneration as assessed with Fluoro-Jade C staining to a greater extent than midazolam alone, and most reduced astrogliosis as assessed by GFAP immunoreactivity but had mixed effects on markers of microglial activation. We conclude that allopregnanolone, a positive modulator of the GABAA receptor, and perampanel, an AMPA receptor antagonist, are potential adjuncts to midazolam in the treatment of benzodiazepine-refractory organophosphate nerve agent-induced status epilepticus.

journal_name

Ann N Y Acad Sci

authors

Dhir A,Bruun DA,Guignet M,Tsai YH,González E,Calsbeek J,Vu J,Saito N,Tancredi DJ,Harvey DJ,Lein PJ,Rogawski MA

doi

10.1111/nyas.14479

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

183-206

issue

1

eissn

0077-8923

issn

1749-6632

journal_volume

1480

pub_type

杂志文章
  • Gait deviations induced by visual motion stimulation in roll depend on head orientation.

    abstract::Locomotion control uses proprioceptive, visual, and vestibular signals. Previously, we analyzed the visual contribution with visual motion stimulation in roll while participants kept their heads in a normal upright orientation. In this study we applied the same visual disturbance in a head-upright and a nose-down cond...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.03846.x

    authors: Bardins S,Schneider E

    更新日期:2009-05-01 00:00:00

  • Activation of a unique population of CD8(+) T cells by intestinal epithelial cells.

    abstract::Intestinal epithelial cells may play a role in the regulation of immune responses toward luminal antigens. We show that a subset of CD8(+) T cells undergoes oligoclonal expansion in the intestinal mucosa, probably through interaction with a unique complex expressed on epithelial cells, formed by a CEA subfamily member...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1309.004

    authors: Allez M,Brimnes J,Shao L,Dotan I,Nakazawa A,Mayer L

    更新日期:2004-12-01 00:00:00

  • 16alpha-hydroxyestrone inhibits estrogen sulfotransferase activity in human liver cancer cells.

    abstract::In this study we investigated the impact of estrogen antagonists and of 16alpha-OHE1 (an estrogen derivative that binds to and induces transactivation of estrogen receptors) on estrogen metabolism in malignant HepG2 human liver cells featured by high estrogen sulfotransferase (EST); our aim was to clarify the potentia...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2008.03694.x

    authors: Campisi I,Granata OM,Cocciadiferro L,Calabrò M,Polito LM,Carruba G

    更新日期:2009-02-01 00:00:00

  • Resource depletion, pollen coupling, and the ecology of mast seeding.

    abstract::Masting, the highly variable and synchronous production of seeds across a population of perennial plants, is an ecologically important, but still poorly understood, phenomenon. While much is known about the fitness benefits of masting and its effects on seed consumers and trophic interactions, less is understood about...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12465

    authors: Crone EE,Rapp JM

    更新日期:2014-08-01 00:00:00

  • Negative regulation of placental fibronectin expression by glucocorticoids and cyclic adenosine 3',5'-monophosphate.

    abstract::Fibronectin is a ubiquitous extracellular matrix (ECM) protein known to play a critical role in cell adhesion. In the present study we dissected the effects of glucocorticoids and cyclic adenosine 3',5'-monophosphate (cAMP) on FN expression in cultures of cytotrophoblasts isolated from human term placentas to identify...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1994.tb21741.x

    authors: Guller S,Wozniak R,Leibman MI,Lockwood CJ

    更新日期:1994-09-30 00:00:00

  • Memory for tonal pitches: a music-length effect hypothesis.

    abstract::One of the most studied effects of verbal working memory (WM) is the influence of the length of the words that compose the list to be remembered. This work aims to investigate the nature of musical WM by replicating the word length effect in the musical domain. Length and rate of presentation were manipulated in a rec...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.04787.x

    authors: Akiva-Kabiri L,Vecchi T,Granot R,Basso D,Schön D

    更新日期:2009-07-01 00:00:00

  • Visualization and phase doppler particle analysis measurements of oscillating spray propagation of an airblast atomizer under typical engine conditions.

    abstract::Propagation of a kerosene spray formed by a prefilming airblast atomizer within a pulsating flame has been investigated. The measurements were performed in a 400 kW single combustor rig at typical engine conditions of up to 0.8 MPa inlet pressure and 673 K inlet temperature. The homogeneity of the fuel spray propagati...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb04585.x

    authors: Schober P,Meier R,Schäfer O,Wittig S

    更新日期:2002-10-01 00:00:00

  • Comparative study of PrPc expression in rat, monkey, and cow gastrointestinal tract.

    abstract::The gastrointestinal tract (GIT) appears to be the main site of entry for the pathological isoform of prions (PrP(sc)). To understand how the PrP(sc) internalization process occurs, it is important to characterize the cell types that express normal prion protein (PrP(c)) along the GIT. To do so, we studied the distrib...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1327.071

    authors: Marcos Z,Bodegas ME,Sesma MP,Guembe L

    更新日期:2005-04-01 00:00:00

  • A multifactorial model for the development of AIDS in homosexual men.

    abstract::The authors present a multifactorial model for the development of acquired immunodeficiency syndrome (AIDS) in homosexual men. It is posited that there is no specific AIDS agent; rather, AIDS is conceptualized as the result of an interaction of the known or likely effects of repeated exposures to specific environment...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1984.tb37134.x

    authors: Sonnabend JA,Witkin SS,Purtilo DT

    更新日期:1984-01-01 00:00:00

  • Modulation of a glial blood-brain barrier.

    abstract::CNS interstitial fluid homeostasis by the glial perineurial blood-brain barrier in the crayfish and cockroach is dependent on glial uptake mechanisms, low paracellular permeability, and the cation-binding properties of the extracellular matrix. Potassium selective permeability of the crayfish perineurium is modulated ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1991.tb15627.x

    authors: Butt AM

    更新日期:1991-01-01 00:00:00

  • Taste preference in nonhuman primates to compounds sweet in man.

    abstract::Primates have stimulated more interest than any other group as humans are ranked in this same mammalian order. Gustatory responses of human and nonhuman primates have already been compared for compounds such as monosaccharides, oligosaccharides, polyols, amino acids, dipeptides, proteins, dihydrochalcones, sulfamates,...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1998.tb10561.x

    authors: Glaser D,Tinti JM,Nofre C

    更新日期:1998-11-30 00:00:00

  • Role of GABA and glutamate circuitry in hypothalamo-pituitary-adrenocortical stress integration.

    abstract::GABA and glutamate play a major role in central integration of hypothalamo-pituitary-adrenocortical (HPA) stress responses. Recent work in our group has focused on mechanisms whereby GABAergic and glutamatergic circuits interact with parvocellular paraventricular nucleus (PVN) neurons controlling the HPA axis. GABAerg...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1296.004

    authors: Herman JP,Mueller NK,Figueiredo H

    更新日期:2004-06-01 00:00:00

  • Dietary advanced glycation endproducts and oxidative stress: in vivo effects on endothelial function and adipokines.

    abstract::Advanced glycation endproducts (AGEs) and oxidative stress (OS) contribute to the development and progression of diabetic complications. We have reported that dietary AGEs and OS induce acute endothelial dysfunction in vivo, but little is known about their effects on adipokines. Twenty inpatients with type 2 diabetes ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1433.042

    authors: Stirban A,Negrean M,Götting C,Uribarri J,Gawlowski T,Stratmann B,Kleesiek K,Koschinsky T,Vlassara H,Tschoepe D

    更新日期:2008-04-01 00:00:00

  • The evolving block universe and the meshing together of times.

    abstract::It has been proposed that spacetime should be regarded as an evolving block universe, bounded to the future by the present time, which continually extends to the future. This future boundary is defined at each time by measuring proper time along Ricci eigenlines from the start of the universe. A key point, then, is th...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12559

    authors: Ellis GF

    更新日期:2014-10-01 00:00:00

  • Age-related inflammatory diseases: role of genetics and gender in the pathophysiology of Alzheimer's disease.

    abstract::Alzheimer's disease (AD) is a heterogeneous and progressive neurodegenerative disease which in Western societies mainly accounts for clinical dementia. A high proportion of women are affected by this disease, especially at a very advanced age, which might to a large extent be associated with the fact that women live l...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1386.008

    authors: Candore G,Balistreri CR,Grimaldi MP,Vasto S,Listì F,Chiappelli M,Licastro F,Lio D,Caruso C

    更新日期:2006-11-01 00:00:00

  • Evidence for the conservation of an immunoreactive monokine network in invertebrates.

    abstract::Mytilus edulis, a marine bivalve mollusc, contains hemocytes that share certain properties with cells of the human monocyte-macrophage lineage. Because of this and previously reported similar responses to opioids between Mytilus hemocytes and human granulocytes, we determined whether Mytilus might also possess monokin...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1992.tb49098.x

    authors: Hughes TK Jr,Smith EM,Leung MK,Stefano GB

    更新日期:1992-04-15 00:00:00

  • Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells.

    abstract::Granulosa cells are known to contribute to maturation of oocytes, and most of the growth factors exert their action via granulosa cells. It has been established that granulosa cell death during follicular atresia and luteolysis results from apoptosis. However, the precise mechanistic pathways of granulosa cell apoptos...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1338.065

    authors: Tsai NM,Hsieh RH,Au HK,Shieh MJ,Huang SY,Tzeng CR

    更新日期:2005-05-01 00:00:00

  • Central nervous correlates of chemical communication in humans.

    abstract::The recording of chemosensory event-related potentials (CSERPs) has been established as an objective method in the assessment of central odor processing in humans. In the present study CSERPs were used to investigate whether human body odor is genetically determined by the major histocompatibility complex (MHC), refer...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1998.tb10634.x

    authors: Krauel K,Pause BM,Mueller C,Sojka B,Mueller-Ruchholtz W,Ferstl R

    更新日期:1998-11-30 00:00:00

  • Enhancement of the Mexican bovine babesiosis vaccine efficacy by using Lactobacillus casei.

    abstract::To evaluate the effect of Lactobacillus casei on the effectiveness of the Mexican bovine babesiosis mixed vaccine, 20 bovines were randomly allocated into four groups of five animals (I, II, III, and IV). At day -2 animals in groups I and II were inoculated with saline solution by intramuscular route (i.m.) and animal...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1428.071

    authors: Bautista CR,Alvarez JA,Mosqueda JJ,Falcon A,Ramos JA,Rojas C,Figueroa JV,Ku M

    更新日期:2008-12-01 00:00:00

  • Methamphetamine dependence: medication development efforts based on the dual deficit model of stimulant addiction.

    abstract::Converging lines of evidence indicate that withdrawal from prolonged exposure to stimulants and alcohol results in synaptic deficits of both dopamine (DA) and serotonin (5-HT). According to the dual deficit model proposed by the authors, DA dysfunction during cocaine or alcohol withdrawal underlies anhedonia and psych...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2000.tb05185.x

    authors: Rothman RB,Partilla JS,Dersch CM,Carroll FI,Rice KC,Baumann MH

    更新日期:2000-09-01 00:00:00

  • Selective cyclin-dependent kinase inhibitors discriminating between cell cycle and transcriptional kinases: future reality or utopia?

    abstract::Progression of the cell cycle is controlled by activating and inhibiting cellular factors. The delicate balance between these positive- and negative-acting regulators warrants proper cell cycle progression in normal cells and facilitates cellular response to a variety of stress stimuli. The increased activity of the p...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2009.04726.x

    authors: Wesierska-Gadek J,Krystof V

    更新日期:2009-08-01 00:00:00

  • Clinical evaluation of a new quantitative enzyme-linked immunosorbent assay for detection of double-stranded DNA autoantibodies.

    abstract::The measurement of autoantibodies specific for double-stranded DNA (anti-dsDNA) is a useful tool for the diagnosis and the prognosis of systemic lupus erythematosus (SLE). A new quantitative enzyme-linked immunosorbent assay (ELISA), ORG anti-dsDNA, is recently available for the determination of anti-dsDNA antibodies....

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1398.057

    authors: Bardin N,Ragot C,Sanmarco M

    更新日期:2007-08-01 00:00:00

  • Endorphins in the cerebrospinal fluid of psychiatric patients.

    abstract::In this paper we have reported the results of studies in psychiatric patient groups using the strategy of measuring opioid activity and beta-endorphin (ir) in CSF. Our findings do not lend support to the notion of excess endorphin activity in schizophrenia, but rather suggest the possibility of a decrease in endogenou...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1982.tb39511.x

    authors: Pickar D,Naber D,Post RM,van Kammen DP,Kaye W,Rubinow DR,Ballenger JC,Bunney WE Jr

    更新日期:1982-01-01 00:00:00

  • Clinical Features of CADASIL.

    abstract::Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare hereditary disease characterized by recurrent transient ischemic attacks, strokes, and vascular dementia. Various mutations in the Notch3 gene cause the disease, whereas the mechanism of how they cause the di...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb04825.x

    authors: Abe K,Murakami T,Matsubara E,Manabe Y,Nagano I,Shoji M

    更新日期:2002-11-01 00:00:00

  • Antioxidant vitamins and prevention of lung disease.

    abstract::Although the evidence for oxidative stress for air pollution in the human lung is fragmentary, the hypothesis that oxidative stress is an important, if not the sole, mechanism of toxicity of oxidizing air pollutants and tobacco smoke is compelling and growing. First, biochemical mechanisms have been worked out for oxi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1992.tb17095.x

    authors: Menzel DB

    更新日期:1992-09-30 00:00:00

  • Effector memory CD8+ T cells are resistant to apoptosis.

    abstract::Based upon their migrating properties and effector functions, CD8(+) T cells have been further classified into central memory (T(CM)) and two types of effector memory (T(EM) and T(EMRA)) cells. These memory cells display distinct replicative characteristics. Because apoptosis plays an important role in cellular homeos...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1398.017

    authors: Gupta S,Gollapudi S

    更新日期:2007-08-01 00:00:00

  • 1,111 patients with adrenal incidentalomas observed at a single endocrinological center: incidence of chromaffin tumors.

    abstract::A majority of incidentally found adrenal tumors derive from the adrenal cortex. The aim of our study was evaluation of the incidence of chromaffin tumors in a group of 1,111 patients with adrenal incidentalomas. In this group there were 803 women and 308 men, aged 10-87 years. Clinical examination, imaging studies (ul...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1353.004

    authors: Kasperlik-Zaluska AA,Roslonowska E,Slowinska-Srzednicka J,Otto M,Cichocki A,Cwikla J,Slapa R,Eisenhofer G

    更新日期:2006-08-01 00:00:00

  • Intracellular localization of alpha-tocopherol transfer protein and alpha-tocopherol.

    abstract::The mechanism of action of tocopherol transfer protein (TTP) and its role in the intracellular processing of vitamin E were investigated using confocal fluorescence microscopy. The results from this work suggest that TTP functions by transporting vitamin E from endocytic organelles to other locations in the cell. ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1331.034

    authors: Qian J,Wilson K,Nava P,Morley S,Atkinson J,Manor D

    更新日期:2004-12-01 00:00:00

  • Oral tolerance and accessory-cell function of Peyer's patches.

    abstract::Whole and nonadherent Peyer's patch cells were shown to present antigen to cloned antigen specific T-cells, albeit less efficiently than spleen cells. Unlike spleen cells, adherent PP cells did not present antigen, and PP lacked cells with classical dendritic morphology. The antigen presenting and MLR-stimulating cell...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1983.tb26865.x

    authors: Tomasi TB,Barr WG,Challacombe SJ,Curran G

    更新日期:1983-06-30 00:00:00

  • Antibodies toward high-density lipoprotein components inhibit paraoxonase activity in patients with systemic lupus erythematosus.

    abstract::Patients with systemic lupus erythematosus (SLE) have an increased incidence of vascular disease, and oxidative stress is recognized as an important feature in this condition, despite the underlying mechanisms not being fully understood. In these patients, an interaction between lipoproteins and the immune system has ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1422.016

    authors: Batuca JR,Ames PR,Isenberg DA,Alves JD

    更新日期:2007-06-01 00:00:00