The human translational vestibulo-ocular reflex in response to complex motion.

Abstract:

:We studied the translational vestibulo-ocular reflex (tVOR) in four healthy human subjects during complex, unpredictable sum-of-sines head motion (combination of 0.73, 1.33, 1.93, and 2.93 Hz), while subjects viewed a target 15 cm away. Ideal eye velocity was calculated from recorded head motion; actual eye velocity was measured with scleral coils. The gain and phase for each frequency component was determined by least-squares optimization. Gain averaged approximately 40% and did not change with frequency; phase lag increased with frequency to a maximum of 66°. Fitting actual to ideal eye velocity predicted a tVOR latency of 48 m/s for vertical and 38 m/s for horizontal translation. These findings provide further evidence that the normal tVOR is considerably undercompensatory, even at low frequencies if the stimulus is not predictable. The similarity of this behavior to that of pursuit suggests that these two eye movements may share some aspects of neural processing.

journal_name

Ann N Y Acad Sci

authors

Walker M,Liao K

doi

10.1111/j.1749-6632.2011.06167.x

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

242-8

eissn

0077-8923

issn

1749-6632

journal_volume

1233

pub_type

杂志文章
  • The development of lurasidone for bipolar depression.

    abstract::Bipolar disorder is a chronic, recurrent illness that ranks among the top 10 causes of disability in the developed world. As the illness progresses, major depressive episodes increasingly predominate. However, few treatment options are available that have demonstrated efficacy in the treatment of bipolar depression, e...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12965

    authors: Loebel A,Xu J,Hsu J,Cucchiaro J,Pikalov A

    更新日期:2015-11-01 00:00:00

  • Effects of testosterone on cognitive and brain aging in elderly men.

    abstract::Older age is associated with functional declines throughout the body, including some aspects of cognitive performance. While dementia develops in only some elderly individuals, declines in cognitive functioning have an impact on daily living for many others. There are individual differences in age-related cognitive ch...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1323.014

    authors: Moffat SD

    更新日期:2005-12-01 00:00:00

  • Assessment of climate-coccidioidomycosis model: model sensitivity for assessing climatologic effects on the risk of acquiring coccidioidomycosis.

    abstract::Understanding the predictive relationships between climate variability and coccidioidomycosis is of great importance for the development of an effective public health decision-support system. Preliminary regression-based climate modeling studies have shown that about 80% of the variance in seasonal coccidioidomycosis ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1406.024

    authors: Comrie AC,Glueck MF

    更新日期:2007-09-01 00:00:00

  • Abnormalities of energy metabolism in Alzheimer's disease studied with PET.

    abstract::Positron emission tomography (PET) is currently the only technology affording three-dimensional measurement of the brain's energy metabolism which is closely coupled to brain function. Studies of glucose metabolism by PET of (18F)-2-fluoro-2-deoxy-D-glucose are therefore widely applied to show the contribution of vari...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1991.tb00192.x

    authors: Heiss WD,Szelies B,Kessler J,Herholz K

    更新日期:1991-01-01 00:00:00

  • Exploring the birth and death of black holes and other creatures.

    abstract::Astronomers and physicists of diverse interest are teaming up to study enigmatic cosmic phenomena, such as the life cycle of black holes. A "disruptive innovation" is about to emerge during the next decade: Advanced gravitational-wave observatories. The emergence of gravitational-wave physics as a viable observational...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2011.06414.x

    authors: Márka S

    更新日期:2012-07-01 00:00:00

  • Common molecular pathways in skeletal morphogenesis and repair.

    abstract::The formation of bone is a continual process in vertebrate development, initiated during fetal development and persisting in adulthood in the form of remodeling and repair. The remarkable capacity of skeletal tissues to regenerate has led to the hypothesis that the molecular signaling pathways regulating skeletogenesi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1998.tb10105.x

    authors: Ferguson CM,Miclau T,Hu D,Alpern E,Helms JA

    更新日期:1998-10-23 00:00:00

  • ADAMTS1: a matrix metalloprotease with angioinhibitory properties.

    abstract::Neovascularization is a hallmark of cancer progression. Suppression of the angiogenic response in tumors has been associated with inhibition and even regression of total tumor mass. Therefore, the derivation of synthetic or natural products that could interfere with proangiogenic signaling pathways can greatly impact ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2003.tb03221.x

    authors: Iruela-Arispe ML,Carpizo D,Luque A

    更新日期:2003-05-01 00:00:00

  • Percepts from scala tympani stimulation.

    abstract::The characteristics of the sensations produced by activating one electrode at a time are summarized as follows: (a) Loudness was found to increase with current level and pitch with repetition rate. (b) Pitch and sharpness increased in the apical-to-basal direction, and vowel labels could be assigned to sensations prod...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1983.tb31639.x

    authors: Tong YC,Clark GM

    更新日期:1983-01-01 00:00:00

  • Molecular dynamics of ions in two forms of an electroactive polymer.

    abstract::Molecular dynamics (MD) are performed in all-atom simulations of two polymer species based on polythiophene. In one case the amphiphilic polymer forms a monolayer interface between a vacuum and an aqueous layer containing ions. The electroactive nature of the polymer is invoked by conferring a negative charge on it to...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.04095.x

    authors: Morton-Blake DA,Leith D

    更新日期:2009-04-01 00:00:00

  • Identification of chronic cocaine-induced gene expression through dopamine d1 receptors by using cDNA microarrays.

    abstract::A major goal of drug abuse research is to understand the molecular mechanisms underlying the behavioral changes caused by repeated exposure to cocaine. Enduring behavioral changes, such as behavioral sensitization, can be induced in rodents by repeated cocaine administration. The neurobiological mechanisms underlying ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb04146.x

    authors: Zhang J,Zhang D,Xu M

    更新日期:2002-06-01 00:00:00

  • Differentiated cerebrovascular effects of physostigmine and tacrine in cortical areas deafferented from the nucleus basalis magnocellularis suggest involvement of basalocortical projections to microvessels.

    abstract::Cholinesterase inhibitors used to treat Alzheimer's disease according to the principle of cholinergic replacement therapy have proved to be less beneficial than expected. The present study was designed to investigate the cerebrovascular response to physostigmine and tacrine in the experimental model of lesioning of th...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb06391.x

    authors: Peruzzi P,von Euw D,Lacombe P

    更新日期:2000-04-01 00:00:00

  • CRE-enhancer DNA decoy: a tumor target-based genetic tool.

    abstract::Enhancer DNA decoy oligonucleotides (ODNs) inhibit transcription by competing for transcription factors. A decoy ODN composed of the cAMP response element (CRE) inhibits CRE-directed gene transcription and tumor growth without affecting normal cell growth. We used DNA microarrays to analyze the global gene expression ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1281.011

    authors: Cho-Chung YS

    更新日期:2003-12-01 00:00:00

  • Role of GABA and glutamate circuitry in hypothalamo-pituitary-adrenocortical stress integration.

    abstract::GABA and glutamate play a major role in central integration of hypothalamo-pituitary-adrenocortical (HPA) stress responses. Recent work in our group has focused on mechanisms whereby GABAergic and glutamatergic circuits interact with parvocellular paraventricular nucleus (PVN) neurons controlling the HPA axis. GABAerg...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1296.004

    authors: Herman JP,Mueller NK,Figueiredo H

    更新日期:2004-06-01 00:00:00

  • New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors.

    abstract::The class of adhesion G protein-coupled receptors (aGPCRs), with 33 human homologs, is the second largest family of GPCRs. In addition to a seven-transmembrane α-helix-a structural feature of all GPCRs-the class of aGPCRs is characterized by the presence of a large N-terminal extracellular region. In addition, all aGP...

    journal_title:Annals of the New York Academy of Sciences

    pub_type:

    doi:10.1111/nyas.12580

    authors: Liebscher I,Ackley B,Araç D,Ariestanti DM,Aust G,Bae BI,Bista BR,Bridges JP,Duman JG,Engel FB,Giera S,Goffinet AM,Hall RA,Hamann J,Hartmann N,Lin HH,Liu M,Luo R,Mogha A,Monk KR,Peeters MC,Prömel S,Ressl S,Sc

    更新日期:2014-12-01 00:00:00

  • Modulatory factors of circadian phagocytic activity.

    abstract::Basal phagocytosis of neutrophils, a crucial component of non-specific immunity, is an eminently circadian parameter. In mice and rats, rates of phagocytosis peak in the second half of the dark span. A lipopolysaccharide-induced phagocytic response challenged in this period appears the most significant in amplitude an...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1356.032

    authors: Hriscu ML

    更新日期:2005-12-01 00:00:00

  • The dynamics of the hostage taker: some major variants.

    abstract::This paper represents a unique effort to elucidate the dynamics of two major types of politically motivated hostage takers. The data presented are derived from an ongoing research project that is gathering extensive interview and psychological test materials from prisoners convicted of politically motivated crimes, bo...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1980.tb21261.x

    authors: Knutson JN

    更新日期:1980-01-01 00:00:00

  • Implications of tuberculosis in African wildlife and livestock.

    abstract::In most countries, tuberculosis caused by Mycobacterium bovis is mainly a disease of domestic cattle and can be controlled successfully by means of a test-and-slaughter program. Once the infection spills over into a wild animal species with maintenance host potential, conventional measures are no longer sufficient to ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2002.tb04387.x

    authors: Michel AL

    更新日期:2002-10-01 00:00:00

  • Stress, leukocyte trafficking, and the augmentation of skin immune function.

    abstract::Delayed type hypersensitivity (DTH) reactions represent cell-mediated immune responses that exert important immunoprotective (resistance to viruses, bacteria, and fungi) or immunopathologic (allergic or autoimmune hypersensitivity) effects. We have used the skin DTH response as an in vivo model to study neuro-endocrin...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2003.tb03151.x

    authors: Dhabhar FS

    更新日期:2003-05-01 00:00:00

  • Origins of the plant chloroplasts and mitochondria based on comparisons of 5S ribosomal RNAs.

    abstract::In this paper, we provide macromolecular comparisons utilizing the 5S ribosomal RNA structure to suggest extant bacteria that are the likely descendants of chloroplast and mitochondria endosymbionts. The genetic stability and near universality of the 5S ribosomal gene allows for a useful means to study ancient evolut...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1987.tb40601.x

    authors: Delihas N,Fox GE

    更新日期:1987-01-01 00:00:00

  • Peeling the onion: understanding layers of treatment.

    abstract::How can a psychoanalyst account for and recount the process of understanding the therapeutic endeavor? What happens in those moments, co-created by patient and analyst, when the consultation room comes "alive" in ways that defy easy or simplistic answers? How does an analyst come to understand psychoanalytic treatment...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 传,历史文章,杂志文章

    doi:10.1111/j.1749-6632.2009.04475.x

    authors: Gotthold JJ

    更新日期:2009-04-01 00:00:00

  • Nephroblastoma overexpressed (Nov) is a novel bone morphogenetic protein antagonist.

    abstract::Nephroblastoma overexpressed (Nov), a member of the CCN family of proteins, is expressed by osteoblasts and its transcription is regulated by transforming growth factor (TGF)-beta and bone morphogenetic proteins (BMP). CCN proteins can interact with TGF-beta, BMPs, and Wnt. We explored the function of Nov in skeletal ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1402.055

    authors: Canalis E

    更新日期:2007-11-01 00:00:00

  • Vaccines against Francisella tularensis.

    abstract::Francisella tularensis is one of the most pathogenic pathogens known, especially when disseminated as a small particle aerosol. Because of this, it was developed into a biological warfare agent by several states during the 20th century. Nowadays, concerns remain about the potential of this pathogen to cause widespread...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1409.012

    authors: Wayne Conlan J,Oyston PC

    更新日期:2007-06-01 00:00:00

  • Sexually dimorphic actions of glucocorticoids: beyond chromosomes and sex hormones.

    abstract::Sexual dimorphism is a well-documented phenomenon that is observed at all levels of the animal kingdom. Historically, sex hormones (testosterone and estrogen) have been implicated as key players in a wide array of pathologies displaying sexual dimorphism in their etiology and progression. While these hormones clearly ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12425

    authors: Quinn M,Ramamoorthy S,Cidlowski JA

    更新日期:2014-05-01 00:00:00

  • Justifying instrumental techniques of analytical chemistry.

    abstract::In this paper, we argue that the foundations of chemistry rely as much on the methods of measurement as they do on categories of chemical substance. To some degree, chemists perform the work of knowledge engineering: designing complex systems for the efficient retrieval of information. Indeed, in some cases, methods o...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2003.tb06106.x

    authors: Rothbart D,Kohout L

    更新日期:2003-05-01 00:00:00

  • Midbrain disorders of vertical gaze: a quantitative re-evaluation.

    abstract::The mesodiencephalic junction is the site of the prenuclear control of vertical eye motion. We measured vertical saccades, smooth pursuit (SP), the vertical vestibulo-ocular reflex (VOR), and its interactions with vision during active head motion in 21 patients with midbrain lesions causing palsy of vertical saccades,...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb02815.x

    authors: Sharpe JA,Kim JS

    更新日期:2002-04-01 00:00:00

  • In vitro clonal analysis of cardiac outflow tract mesenchyme.

    abstract::In vitro clonal analyses were performed to gain insight into the mechanisms that control development of neural crest-derived cardiac outflow tract mesenchyme of quail embryos. The cardiac neural crest originates from the posterior rhombencephalic neural tube. The cells leave the neural tube and migrate through the pos...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1995.tb17409.x

    authors: Sieber-Blum M,Ito K

    更新日期:1995-03-27 00:00:00

  • Aftereffects of vestibular and optokinetic stimulation and their interaction.

    abstract::In humans the influence of prior vestibular stimulation (3, 6, 9, 12, and 18 degrees/second2 for 10 seconds) and subsequent whole-field optokinetic stimulation (30, 60, 90, 120, and 180 degrees/second for 1 minute) or the presentation of a stationary pattern on after-nystagmus (AN) was studied. For comparison, pure ve...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1981.tb30889.x

    authors: Koenig E,Dichgans J

    更新日期:1981-01-01 00:00:00

  • Karyotype-phenotype correlation in females with X chromosome abnormalities.

    abstract::In mammals, females have a pair of X chromosomes, whereas males have one X chromosome and one Y chromosome, which is much smaller and contains fewer genes than a X chromosome. One of the pair of X chromosomes is inactivated in females. The inactivated X chromosome is late-replicating, heterochromatic, and genetically ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1997.tb52164.x

    authors: Kosmaidou-Aravidou Z

    更新日期:1997-06-17 00:00:00

  • Oxidative basis of manganese neurotoxicity.

    abstract::Exposure to excessive levels of manganese, an essential trace element, can evoke severe psychiatric and extrapyramidal motor dysfunction closely resembling Parkinson's disease. The clinical manifestations of manganese toxicity arise from focal injury to the basal ganglia. This region, characterized by intense consumpt...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1306.010

    authors: HaMai D,Bondy SC

    更新日期:2004-03-01 00:00:00

  • Gamma-tocopherol induces apoptosis in androgen-responsive LNCaP prostate cancer cells via caspase-dependent and independent mechanisms.

    abstract::We found that gamma-tocopherol, the predominant vitamin E form in diets, but not alpha-tocopherol, which is the exclusive form of vitamin E in most supplements, exhibited antiproliferation effect on prostate (PC-3, LNCaP) and lung (A549) cancer cells. gamma-Tocopherol induced apoptosis in androgen-sensitive LNCaP but ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1331.056

    authors: Jiang Q,Wong J,Ames BN

    更新日期:2004-12-01 00:00:00