Abstract:
:Epidemiological studies of related individuals are often complicated by the fact that follow-up on the event type of interest is incomplete due to the occurrence of other events. We suggest a class of frailty models with cause-specific hazards for correlated competing events in related individuals. The frailties are based on sums of gamma distributed variables and offer closed form expressions for the observed intensities. An inference procedure with a recursive baseline estimator is proposed, and its large sample properties are established. The estimator readily handles cluster left-truncation as occurring in the Nordic twin registers. The performance in finite samples is investigated by simulations and an example on prostate cancer in twins is provided for illustration.
journal_name
Biometricsjournal_title
Biometricsauthors
Eriksson F,Scheike Tdoi
10.1111/biom.12326subject
Has Abstractpub_date
2015-09-01 00:00:00pages
677-86issue
3eissn
0006-341Xissn
1541-0420journal_volume
71pub_type
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