A two-stage stepwise estimation procedure.

abstract：:We introduce two test procedures for comparing two survival distributions on the basis of randomly right-censored data consisting of both paired and unpaired observations. Our procedures are based on generalizations of a pooled rank test statistic previously proposed for uncensored data. One generalization adapts the ...

journal_title：Biometrics

authors： Dallas MJ,Rao PV

更新日期：2000-03-01 00:00:00

abstract：:This paper proposes a generalized estimating equations approach for the analysis of spatially correlated binary data when there are large numbers of spatially correlated observations on a moderate number of subjects. This approach is useful when the scientific focus is on modeling the marginal mean structure. Proper m...

journal_title：Biometrics

authors： Albert PS,McShane LM

更新日期：1995-06-01 00:00:00

abstract：:Thanks to the growing interest in personalized medicine, joint modeling of longitudinal marker and time-to-event data has recently started to be used to derive dynamic individual risk predictions. Individual predictions are called dynamic because they are updated when information on the subject's health profile grows ...

journal_title：Biometrics

authors： Blanche P,Proust-Lima C,Loubère L,Berr C,Dartigues JF,Jacqmin-Gadda H

更新日期：2015-03-01 00:00:00

abstract：:We consider the problem of testing for a dose-related effect based on a candidate set of (typically nonlinear) dose-response models using likelihood-ratio tests. For the considered models this reduces to assessing whether the slope parameter in these nonlinear regression models is zero or not. A technical problem is t...

journal_title：Biometrics

authors： Gutjahr G,Bornkamp B

更新日期：2017-03-01 00:00:00

abstract：:We consider the problem of estimating a population size from successive catches taken during a removal experiment and propose two estimating functions approaches, the traditional quasi-likelihood (TQL) approach for dependent observations and the conditional quasi-likelihood (CQL) approach using the conditional mean an...

journal_title：Biometrics

authors： Wang YG

更新日期：1999-12-01 00:00:00

abstract：:We extend the Mantel-Haenszel estimating function to estimate both the intra-cluster pairwise correlation and the main effects for sparse clustered binary data. We propose both a composite likelihood approach and an estimating function approach for the analysis of such data. The proposed estimators are consistent and ...

journal_title：Biometrics

authors： Wang M,Williamson JM

更新日期：2005-12-01 00:00:00

abstract：:Increasingly, genetic studies of tumors of the same histologic diagnosis are elucidating subtypes that are distinct with respect to clinical endpoints such as response to treatment and survival. This raises concerns about the efficiency of using the simple log-rank test for analysis of treatment effect on survival in ...

journal_title：Biometrics

authors： Li Y,Betensky RA,Louis DN,Cairncross JG

更新日期：2002-03-01 00:00:00

abstract：:Conventional statistical determinations of sample size in phase II studies typically lead to sample sizes of the order of 25 (Schoenfeld, 1980, International Journal of Radiation Oncology, Biology and Physics 6, 371-374). When the development of new treatments is proceeding rapidly relative to the recruitment of suita...

journal_title：Biometrics

authors： Whitehead J

更新日期：1985-06-01 00:00:00

abstract：:A general formula for the frequency of different recombinant gamete types, in terms of the underlying distribution of crossovers, is derived. This formula may be applied to any theoretical model of recombination in which it is assumed that there is no chromatid interference. Multiple-locus recombination data may be ev...

journal_title：Biometrics

authors： Risch N,Lange K

更新日期：1983-12-01 00:00:00

abstract：:As ultra high-dimensional longitudinal data are becoming ever more apparent in fields such as public health and bioinformatics, developing flexible methods with a sparse model is of high interest. In this setting, the dimension of the covariates can potentially grow exponentially as ...

journal_title：Biometrics

authors： Green B,Lian H,Yu Y,Zu T

更新日期：2020-08-04 00:00:00

abstract：:Consider case control analysis with a dichotomous exposure variable that is subject to misclassification. If the classification probabilities are known, then methods are available to adjust odds-ratio estimates in light of the misclassification. We study the realistic scenario where reasonable guesses, but not exact v...

journal_title：Biometrics

authors： Gustafson P,Le ND,Saskin R

更新日期：2001-06-01 00:00:00

abstract：:We describe an exact, unconditional, non-randomized procedure for producing confidence intervals for the grand mean in a normal-normal random effects meta-analysis. The procedure targets meta-analyses based on too few primary studies, ≤ 7 , say, to ...

journal_title：Biometrics

authors： Michael H,Thornton S,Xie M,Tian L

更新日期：2019-06-01 00:00:00

abstract：:In an epidemiological study of risk factors in breast cancer, data are available on confirmed cases from a diagnostic clinic and on controls from a screening clinic that sampled the general population. Relative risk estimation is complicated by differences in the interviewing environment and in the wording and order o...

journal_title：Biometrics

authors： Elton RA,Duffy SW

更新日期：1983-09-01 00:00:00

abstract：:We introduce a nearly automatic procedure to locate and count the quantum dots in images of kinesin motor assays. Our procedure employs an approximate likelihood estimator based on a two-component mixture model for the image data; the first component has a normal distribution, and the other component is distributed as...

journal_title：Biometrics

authors： Hughes J,Fricks J

更新日期：2011-06-01 00:00:00

abstract：:Restricted maximum likelihood (REML) is now well established as a method for estimating the parameters of the general Gaussian linear model with a structured covariance matrix, in particular for mixed linear models. Conventionally, estimates of precision and inference for fixed effects are based on their asymptotic di...

journal_title：Biometrics

authors： Kenward MG,Roger JH

更新日期：1997-09-01 00:00:00

abstract：:A life table estimates probabilities of surviving and of dying as well as death rates, as these would apply in a stationary population with the same underlying continuous mortality curve as the observed population. We have derived approximations to the probability of surviving that require no iteration, do not depend ...

journal_title：Biometrics

authors： Keyfitz N,Frauenthal J

更新日期：1975-12-01 00:00:00

abstract：:Within the framework of Fisher's discriminant analysis, we propose a multiclass classification method which embeds variable screening for ultrahigh-dimensional predictors. Leveraging interfeature correlations, we show that the proposed linear classifier recovers informative features with probability tending to one and...

journal_title：Biometrics

authors： Li Y,Hong HG,Li Y

更新日期：2019-12-01 00:00:00

abstract：:This paper establishes a framework for understanding the complex relationships between HIV-1 genotypic markers of resistance to antiretroviral drugs and clinical measures of disease progression. A new classification scheme based on the probabilities of how new patients will respond to antiretroviral therapy given the ...

journal_title：Biometrics

authors： Foulkes AS,De GV

更新日期：2002-03-01 00:00:00

abstract：:This article introduces an original methodology based on empirical likelihood, which aims at combining different food contamination and consumption surveys to provide risk managers with a risk measure, taking into account all the available information. This risk index is defined as the probability that exposure to a c...

journal_title：Biometrics

authors： Crépet A,Harari-Kermadec H,Tressou J

更新日期：2009-03-01 00:00:00

abstract：:This paper is concerned with the analysis of multivariate categorical data which are obtained from repeated measurement experiments. An expository discussion of pertinent hypotheses for such situations is given, and appropriate test statistics are developed through the application of weighted least squares methods. Sp...

journal_title：Biometrics

authors： Koch GG,Landis JR,Freeman JL,Freeman DH Jr,Lehnen RC

更新日期：1977-03-01 00:00:00

abstract：:This note discusses the use of capture-mark-recapture methods and log-linear, linear, product models for incomplete tables (Espeland, 1986, Communications in Statistics--Simulation and Computing 15, 405-424) to estimate completeness of reporting in a disease registry and to estimate incompleteness-adjusted incidence r...

journal_title：Biometrics

authors： Hilsenbeck SG,Kurucz C,Duncan RC

更新日期：1992-12-01 00:00:00

abstract：:In this article, we propose approximate sample size formulas for establishing equivalence or noninferiority of two treatments in match-pairs design. Using the ratio of two proportions as the equivalence measure, we derive sample size formulas based on a score statistic for two types of analyses: hypothesis testing and...

journal_title：Biometrics

authors： Tang ML,Tang NS,Chan IS,Chan BP

更新日期：2002-12-01 00:00:00

abstract：:Inference for continuous time multi-state models presents considerable computational difficulties when the process is only observed at discrete time points with no additional information about the state transitions. In fact, for general multi-state Markov model, evaluation of the likelihood function is possible only v...

journal_title：Biometrics

authors： Tancredi A

更新日期：2019-09-01 00:00:00

abstract：:Epidemiological studies involving biomarkers are often hindered by prohibitively expensive laboratory tests. Strategically pooling specimens prior to performing these lab assays has been shown to effectively reduce cost with minimal information loss in a logistic regression setting. When the goal is to perform regress...

journal_title：Biometrics

authors： Mitchell EM,Lyles RH,Manatunga AK,Danaher M,Perkins NJ,Schisterman EF

更新日期：2014-03-01 00:00:00

abstract：:Receiver operating characteristic (ROC) curves are frequently used to assess the usefulness of diagnostic markers. When several diagnostic markers are available, they can be combined by a best linear combination: that is, when the area under the ROC curve of this combination is maximized among all possible linear comb...

journal_title：Biometrics

authors： Reiser B,Faraggi D

更新日期：1997-06-01 00:00:00

abstract：:We consider a semiparametric regression model that relates a normal outcome to covariates and a genetic pathway, where the covariate effects are modeled parametrically and the pathway effect of multiple gene expressions is modeled parametrically or nonparametrically using least-squares kernel machines (LSKMs). This un...

journal_title：Biometrics

authors： Liu D,Lin X,Ghosh D

更新日期：2007-12-01 00:00:00

abstract：:Recent developments in the animal breeding literature facilitate estimation of the variance components in quantitative genetic models. However, computation remains intensive, and many of the procedures are restricted to specialized designs and models, unsuited to data arising from studies of natural populations. We de...

journal_title：Biometrics

authors： Thompson EA,Shaw RG

更新日期：1990-06-01 00:00:00

abstract：:The feasibility and cost-effectiveness of estimation of kappa using a case-control method of sampling, proposed by Jannarone, Macera, and Garrison (1987, Biometrics 43, 433-437), is provided support. However, in this article unrealistic assumptions in their presentation are identified and more general results for more...

journal_title：Biometrics

authors： Kraemer HC,Bloch DA

更新日期：1990-03-01 00:00:00

abstract：:In biostatistical practice, it is common to use information criteria as a guide for model selection. We propose new versions of the focused information criterion (FIC) for variable selection in logistic regression. The FIC gives, depending on the quantity to be estimated, possibly different sets of selected variables....

journal_title：Biometrics

authors： Claeskens G,Croux C,Van Kerckhoven J

更新日期：2006-12-01 00:00:00

abstract：:This paper presents a comparison of three methods of parameter estimation in analysis of linkage between a quantitative trait locus (QTL) and a marker locus: maximum likelihood, mean square for trait cumulative distribution function, and method of moments, employing simulated backcross data. The sensitivity of estimat...

journal_title：Biometrics

authors： Korol AB,Ronin YI,Kirzhner VM

更新日期：1996-06-01 00:00:00