Abstract:
:A general formula for the frequency of different recombinant gamete types, in terms of the underlying distribution of crossovers, is derived. This formula may be applied to any theoretical model of recombination in which it is assumed that there is no chromatid interference. Multiple-locus recombination data may be evaluated by using this formula in conjunction with a maximum likelihood procedure. The validity of any model of recombination may be tested in such a fashion. The possibilities are demonstrated through application to a generalized noninterference model of crossing over described in a previous paper (Risch and Lange, 1979, Annals of Human Genetics 43, 61-70).
journal_name
Biometricsjournal_title
Biometricsauthors
Risch N,Lange Ksubject
Has Abstractpub_date
1983-12-01 00:00:00pages
949-63issue
4eissn
0006-341Xissn
1541-0420journal_volume
39pub_type
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