Case-control analysis with partial knowledge of exposure misclassification probabilities.

Abstract:

:Consider case control analysis with a dichotomous exposure variable that is subject to misclassification. If the classification probabilities are known, then methods are available to adjust odds-ratio estimates in light of the misclassification. We study the realistic scenario where reasonable guesses, but not exact values, are available for the classification probabilities. If the analysis proceeds by simply treating the guesses as exact, then even small discrepancies between the guesses and the actual probabilities can seriously degrade odds-ratio estimates. We show that this problem is mitigated by a Bayes analysis that incorporates uncertainty about the classification probabilities as prior information.

journal_name

Biometrics

journal_title

Biometrics

authors

Gustafson P,Le ND,Saskin R

doi

10.1111/j.0006-341x.2001.00598.x

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

598-609

issue

2

eissn

0006-341X

issn

1541-0420

journal_volume

57

pub_type

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