A Bayesian hidden Markov model for detecting differentially methylated regions.

abstract：:Calibration, the statistical consistency of forecast distributions and the observations, is a central requirement for probabilistic predictions. Calibration of continuous forecasts is typically assessed using the probability integral transform histogram. In this article, we propose significance tests based on scoring ...

journal_title：Biometrics

authors： Held L,Rufibach K,Balabdaoui F

更新日期：2010-12-01 00:00:00

abstract：:Although the analysis of censored survival data using the proportional hazards and linear regression models is common, there has been little work examining the ability of these estimators to predict time to failure. This is unfortunate, since a predictive plot illustrating the relationship between time to failure and ...

journal_title：Biometrics

authors： Heller G,Simonoff JS

更新日期：1992-03-01 00:00:00

abstract：:Dilution assays to determine solute concentration have found wide use in biomedical research. Many dilution assays return imprecise concentration estimates because they are only done to orders of magnitude. Previous statistical work has focused on how to design efficient experiments that can return more precise estima...

journal_title：Biometrics

authors： Ferguson JM,Miura TA,Miller CR

更新日期：2019-09-01 00:00:00

abstract：:One common method for estimating total catch is to multiply an estimate for CPUE, the catch per unit effort, by an estimate of total effort obtained from an independent second survey. In general, estimating total effort requires that sample times are chosen at random over the full fishing period; however, in practice,...

journal_title：Biometrics

authors： Dauk PC,Schwarz CJ

更新日期：2001-06-01 00:00:00

abstract：:Objective measures of oxygen consumption and carbon dioxide production by mammals are used to predict their energy expenditure. Since energy expenditure is not directly observable, it can be viewed as a latent construct with multiple physical indirect measures such as respiratory quotient, volumetric oxygen consumptio...

journal_title：Biometrics

authors： Tekwe CD,Zoh RS,Bazer FW,Wu G,Carroll RJ

更新日期：2018-03-01 00:00:00

abstract：:We consider a semiparametric inference procedure for data from epidemiologic studies conducted with a two-component sampling scheme where both a simple random sample and multiple outcome- or outcome-/auxiliary-dependent samples are observed. This sampling scheme allows the investigators to oversample certain subpopula...

journal_title：Biometrics

authors： Wang X,Zhou H

更新日期：2006-12-01 00:00:00

abstract：:The Wilcoxon rank sum test is widely used for two-group comparisons for nonnormal data. An assumption of this test is independence of sampling units both between and within groups. In ophthalmology, data are often collected on two eyes of an individual, which are highly correlated. In ophthalmological clinical trials,...

journal_title：Biometrics

authors： Rosner B,Glynn RJ,Lee ML

更新日期：2006-12-01 00:00:00

abstract：:We present a method for individual and integrative analysis of high dimension, low sample size data that capitalizes on the recurring theme in multivariate analysis of projecting higher dimensional data onto a few meaningful directions that are solutions to a generalized eigenvalue problem. We propose a general framew...

journal_title：Biometrics

authors： Safo SE,Ahn J,Jeon Y,Jung S

更新日期：2018-12-01 00:00:00

abstract：:Life-table methodology for interval-censored survival times is used to estimate marginal survival probabilities from data consisting of independent cohorts of correlated responses. We restrict our attention to situations where response times within cohorts are exchangeable and the marginal survival distributions are t...

journal_title：Biometrics

authors： Kang SS,Koehler KJ

更新日期：1997-09-01 00:00:00

abstract：:In this article, we propose a new statistical method-MutRSeq-for detecting differentially expressed single nucleotide variants (SNVs) based on RNA-seq data. Specifically, we focus on nonsynonymous mutations and employ a hierarchical likelihood approach to jointly model observed mutation events as well as read count me...

journal_title：Biometrics

authors： Fu R,Wang P,Ma W,Taguchi A,Wong CH,Zhang Q,Gazdar A,Hanash SM,Zhou Q,Zhong H,Feng Z

更新日期：2017-03-01 00:00:00

abstract：:Vaccine-induced protection may not be homogeneous across individuals. It is possible that a vaccine gives complete protection for a portion of individuals, while the rest acquire only incomplete (leaky) protection of varying magnitude. If vaccine efficacy is estimated under wrong assumptions about such individual leve...

journal_title：Biometrics

authors： Mehtälä J,Dagan R,Auranen K

更新日期：2016-09-01 00:00:00

abstract：:Image-on-image regression analysis, using images to predict images, is a challenging task, due to (1) the high dimensionality and (2) the complex spatial dependence structures in image predictors and image outcomes. In this work, we propose a novel image-on-image regression model, by extending a spatial Bayesian laten...

journal_title：Biometrics

authors： Guo C,Kang J,Johnson TD

更新日期：2020-12-27 00:00:00

abstract：:It is not, in general, possible to include all relevant risk factors in a model of survival or disease incidence. This heterogeneity must be accounted for in the interpretation, as it can imply otherwise unexpected results. This is illustrated by diabetic nephropathy, a serious complication experienced by some diabeti...

journal_title：Biometrics

authors： Hougaard P,Myglegaard P,Borch-Johnsen K

更新日期：1994-12-01 00:00:00

abstract：:In many longitudinal clinical studies, the level and progression rate of repeatedly measured biomarkers on each subject quantify the severity of the disease and that subject's susceptibility to progression of the disease. It is of scientific and clinical interest to relate such quantities to a later time-to-event clin...

journal_title：Biometrics

authors： Li L,Hu B,Greene T

更新日期：2009-09-01 00:00:00

abstract：:The risks of conception, due to sexual intercourse at various times before and after the periovulatory rise in the woman's basal body temperature, are evaluated. In general, the risk is small nine or more days before, and two or more days after, the first day of elevated temperature. The model for the conception proba...

journal_title：Biometrics

authors： Royston JP

更新日期：1982-06-01 00:00:00

abstract：:We describe group sequential tests for a bivariate response. The tests are defined in terms of the two response components jointly, rather than through a single summary statistic. Such methods are appropriate when the two responses concern different aspects of a treatment; for example, one might wish to show that a ne...

journal_title：Biometrics

authors： Jennison C,Turnbull BW

更新日期：1993-09-01 00:00:00

abstract：:Highly active antiretroviral therapy (HAART) has proved efficient in increasing CD4 counts in many randomized clinical trials. Because randomized trials have some limitations (e.g., short duration, highly selected subjects), it is interesting to assess the effect of treatments using observational studies. This is chal...

journal_title：Biometrics

authors： Prague M,Commenges D,Gran JM,Ledergerber B,Young J,Furrer H,Thiébaut R

更新日期：2017-03-01 00:00:00

abstract：:Gene-disease association studies based on case-control designs may often be used to identify candidate polymorphisms (markers) conferring disease risk. If a large number of markers are studied, genotyping all markers on all samples is inefficient in resource utilization. Here, we propose an alternative two-stage metho...

journal_title：Biometrics

authors： Satagopan JM,Venkatraman ES,Begg CB

更新日期：2004-09-01 00:00:00

abstract：:A novel nonparametric regression model is developed for evaluating the covariate-specific accuracy of a continuous biological marker. Accurately screening diseased from nondiseased individuals and correctly diagnosing disease stage are critically important to health care on several fronts, including guiding recommenda...

journal_title：Biometrics

authors： Inácio de Carvalho V,de Carvalho M,Branscum AJ

更新日期：2017-12-01 00:00:00

abstract：:Five procedures are considered for the comparison of two or more multivariate samples. These procedures include a newly proposed nonparametric rank-sum test and a generalized least squares test. Also considered are the following tests: ordinary least squares, Hotelling's T2, and a Bonferroni per-experiment error-rate ...

journal_title：Biometrics

authors： O'Brien PC

更新日期：1984-12-01 00:00:00

abstract：:Many problems that appear in biomedical decision-making, such as diagnosing disease and predicting response to treatment, can be expressed as binary classification problems. The support vector machine (SVM) is a popular classification technique that is robust to model misspecification and effectively handles high-dime...

journal_title：Biometrics

authors： Luckett DJ,Laber EB,El-Kamary SS,Fan C,Jhaveri R,Perou CM,Shebl FM,Kosorok MR

更新日期：2020-08-31 00:00:00

abstract：:The variogram is a standard tool in the analysis of spatial data, and its shape provides useful information on the form of spatial correlation that may be present. However, it is also useful to be able to assess the evidence for the presence of any spatial correlation. A method of doing this, based on an assessment of...

journal_title：Biometrics

authors： Diblasi A,Bowman AW

更新日期：2001-03-01 00:00:00

abstract：SUMMARY:Nonparametric regression models are proposed in the framework of ecological inference for exploratory modeling of disease prevalence rates adjusted for variables, such as age, ethnicity/race, and socio-economic status. Ecological inference is needed when a response variable and covariate are not available at th...

journal_title：Biometrics

authors： Staniswalis JG

更新日期：2008-12-01 00:00:00

abstract：:Stepped wedge designed trials are a type of cluster-randomized study in which the intervention is introduced to each cluster in a random order over time. This design is often used to assess the effect of a new intervention as it is rolled out across a series of clinics or communities. Based on a permutation argument, ...

journal_title：Biometrics

authors： Hughes JP,Heagerty PJ,Xia F,Ren Y

更新日期：2020-03-01 00:00:00

abstract：:Currently, the design of group sequential clinical trials requires choosing among several distinct design categories, design scales, and strategies for determining stopping rules. This approach can limit the design selection process so that clinical issues are not fully addressed. This paper describes a family of desi...

journal_title：Biometrics

authors： Kittelson JM,Emerson SS

更新日期：1999-09-01 00:00:00

abstract：:In many applications of generalized linear mixed models to multilevel data, it is of interest to test whether a random effects variance component is zero. It is well known that the usual asymptotic chi-square distribution of the likelihood ratio and score statistics under the null does not necessarily hold. In this no...

journal_title：Biometrics

authors： Fitzmaurice GM,Lipsitz SR,Ibrahim JG

更新日期：2007-09-01 00:00:00

abstract：:A study of otitis media that requires a test for the comparison of two clustered samples of censored data is described. A method is proposed taking into account the within-subject correlation in the formation of the log-rank statistic. ...

journal_title：Biometrics

authors： Le CT,Lindgren BR

更新日期：1996-03-01 00:00:00

abstract：:The aim of this study is to estimate incidence rates of onchocerciasis from skin-snip biopsies, based on incomplete data obtained in field surveys, with consideration of false negatives. The method of maximum likelihood is employed and the effect of false negatives on the incidence rates is discussed. ...

journal_title：Biometrics

authors： Yanagawa T,Kasagi F,Yoshimura T

更新日期：1984-06-01 00:00:00

abstract：:Bayesian experimental design is investigated for Bayesian analysis of nonlinear mixed-effects models. Existence of the posterior risk for parameter estimation is shown. When the same prior distribution is used for both design and inference, existence of the preposterior risk for design is also proven. If the prior dis...

journal_title：Biometrics

authors： Han C,Chaloner K

更新日期：2004-03-01 00:00:00

abstract：:This paper proposes a two-stage phase I-II clinical trial design to optimize dose-schedule regimes of an experimental agent within ordered disease subgroups in terms of the toxicity-efficacy trade-off. The design is motivated by settings where prior biological information indicates it is certain that efficacy will imp...

journal_title：Biometrics

authors： Lin R,Thall PF,Yuan Y

更新日期：2020-03-01 00:00:00