Abstract:
:We describe group sequential tests for a bivariate response. The tests are defined in terms of the two response components jointly, rather than through a single summary statistic. Such methods are appropriate when the two responses concern different aspects of a treatment; for example, one might wish to show that a new treatment is both as effective and as safe as the current standard. We present a formulation of the bivariate testing problem, introduce group sequential tests that satisfy Type I error conditions, and show how to find the sample size guaranteeing a specified power. We describe how properties of group sequential tests for bivariate normal observations can be computed by numerical integration.
journal_name
Biometricsjournal_title
Biometricsauthors
Jennison C,Turnbull BWsubject
Has Abstractpub_date
1993-09-01 00:00:00pages
741-52issue
3eissn
0006-341Xissn
1541-0420journal_volume
49pub_type
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