Abstract:
:This paper establishes a framework for understanding the complex relationships between HIV-1 genotypic markers of resistance to antiretroviral drugs and clinical measures of disease progression. A new classification scheme based on the probabilities of how new patients will respond to antiretroviral therapy given the available data is proposed as a method for distinguishing among groups of viral sequences. This approach draws from existing cluster analysis, discriminant analysis, and recursive partitioning techniques and requires a model relating genotypic characteristics to phenotypic response. A data set of 2,746 sequences and the corresponding Indinavir 50% inhibitory concentrations are described and used for illustrative purposes.
journal_name
Biometricsjournal_title
Biometricsauthors
Foulkes AS,De GVdoi
10.1111/j.0006-341x.2002.00145.xsubject
Has Abstractpub_date
2002-03-01 00:00:00pages
145-56issue
1eissn
0006-341Xissn
1541-0420journal_volume
58pub_type
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