Latent Ornstein-Uhlenbeck models for Bayesian analysis of multivariate longitudinal categorical responses.

abstract：:In a presentation of various methods for assessing the sensitivity of regression results to unmeasured confounding, Lin, Psaty, and Kronmal (1998, Biometrics54, 948-963) use a conditional independence assumption to derive algebraic relationships between the true exposure effect and the apparent exposure effect in a re...

journal_title：Biometrics

authors： Vanderweele TJ

更新日期：2008-06-01 00:00:00

abstract：:We consider a semiparametric regression model that relates a normal outcome to covariates and a genetic pathway, where the covariate effects are modeled parametrically and the pathway effect of multiple gene expressions is modeled parametrically or nonparametrically using least-squares kernel machines (LSKMs). This un...

journal_title：Biometrics

authors： Liu D,Lin X,Ghosh D

更新日期：2007-12-01 00:00:00

abstract：:In this article, we consider two-phase sampling in the situation in which all covariates are categorical. Two-phase designs are appealing from an efficiency perspective since they allow sampling to be concentrated in informative cells. A number of likelihood-based methods have been developed for the analysis of two-ph...

journal_title：Biometrics

authors： Ross M,Wakefield J

更新日期：2013-06-01 00:00:00

abstract：:Heart rate oscillates in synchrony with respiration. Several methods have been employed to assess this 'sinus arrhythmia', as an index of autonomic nervous system function. This paper proposes a new, easily computed measure, R, which is relatively resistant to the major nonrespiratory sources of variation, including p...

journal_title：Biometrics

authors： Weinberg CR,Pfeifer MA

更新日期：1984-09-01 00:00:00

abstract：:This paper focuses on the methodology developed for analyzing a multivariate interval-censored data set from an AIDS observational study. A purpose of the study was to determine the natural history of the opportunistic infection cytomeglovirus (CMV) in an HIV-infected individual. For this observational study, laborato...

journal_title：Biometrics

authors： Goggins WB,Finkelstein DM

更新日期：2000-09-01 00:00:00

abstract：:We explore the use of a posterior predictive loss criterion for model selection for incomplete longitudinal data. We begin by identifying a property that most model selection criteria for incomplete data should consider. We then show that a straightforward extension of the Gelfand and Ghosh (1998, Biometrika, 85, 1-11...

journal_title：Biometrics

authors： Daniels MJ,Chatterjee AS,Wang C

更新日期：2012-12-01 00:00:00

abstract：:A novel nonparametric regression model is developed for evaluating the covariate-specific accuracy of a continuous biological marker. Accurately screening diseased from nondiseased individuals and correctly diagnosing disease stage are critically important to health care on several fronts, including guiding recommenda...

journal_title：Biometrics

authors： Inácio de Carvalho V,de Carvalho M,Branscum AJ

更新日期：2017-12-01 00:00:00

abstract：:A wide variety of similarity indices for comparing two assemblages based on species incidence (i.e., presence/absence) data have been proposed in the literature. These indices are generally based on three simple incidence counts: the number of species shared by two assemblages and the number of species unique to each ...

journal_title：Biometrics

authors： Chao A,Chazdon RL,Colwell RK,Shen TJ

更新日期：2006-06-01 00:00:00

abstract：:In many medical experiments, data are collected across time, over a number of similar trials, or over a number of experimental units. As is the case of neuron spike train studies, these data may be in the form of counts of events per unit of time. These counts may be correlated within each trial. It is often of intere...

journal_title：Biometrics

authors： Bélisle P,Joseph L,MacGibbon B,Wolfson DB,du Berger R

更新日期：1998-03-01 00:00:00

abstract：:The estimation of gene frequencies, linkage disequilibrium and disease associations for the human leukocyte antigen (HLA) system is considered. Comprehensive models for HLA data are introduced and contrasted with simpler approaches to the analysis of such data. ...

journal_title：Biometrics

authors： Farewell VT,Dahlberg S

更新日期：1984-06-01 00:00:00

abstract：:In studying the relationship between an ordered categorical predictor and an event time, it is standard practice to include dichotomous indicators of the different levels of the predictor in a Cox model. One can then use a multiple degree-of-freedom score or partial likelihood ratio test for hypothesis testing. Often,...

journal_title：Biometrics

authors： Dunson DB,Herring AH

更新日期：2003-12-01 00:00:00

abstract：:We consider inference for the reaction rates in discretely observed networks such as those found in models for systems biology, population ecology, and epidemics. Most such networks are neither slow enough nor small enough for inference via the true state-dependent Markov jump process to be feasible. Typically, infere...

journal_title：Biometrics

authors： Fearnhead P,Giagos V,Sherlock C

更新日期：2014-06-01 00:00:00

abstract：:Experiments that longitudinally collect RNA sequencing (RNA-seq) data can provide transformative insights in biology research by revealing the dynamic patterns of genes. Such experiments create a great demand for new analytic approaches to identify differentially expressed (DE) genes based on large-scale time-course c...

journal_title：Biometrics

authors： Cao M,Zhou W,Breidt FJ,Peers G

更新日期：2020-03-01 00:00:00

abstract：:Population admixture can be a confounding factor in genetic association studies. Family-based methods (Rabinowitz and Larid, 2000, Human Heredity 50, 211-223) have been proposed in both testing and estimation settings to adjust for this confounding, especially in case-only association studies. The family-based methods...

journal_title：Biometrics

authors： Wang Y,Yang Q,Rabinowitz D

更新日期：2011-06-01 00:00:00

abstract：:We consider Bayesian methodology for comparing two or more unlabeled point sets. Application of the technique to a set of steroid molecules illustrates its potential utility involving the comparison of molecules in chemoinformatics and bioinformatics. We initially match a pair of molecules, where one molecule is regar...

journal_title：Biometrics

authors： Dryden IL,Hirst JD,Melville JL

更新日期：2007-03-01 00:00:00

abstract：:Prentice and Sheppard (1995, Biometrika 82, 113-125) proposed a method for estimating relative risks associated with poorly measured exposures using disease rates from multiple populations and exposure and confounding factor data from sample surveys of persons in each population. The method involved an assumption of i...

journal_title：Biometrics

authors： Anderson AB,Prentice RL

更新日期：1998-12-01 00:00:00

abstract：:A life table estimates probabilities of surviving and of dying as well as death rates, as these would apply in a stationary population with the same underlying continuous mortality curve as the observed population. We have derived approximations to the probability of surviving that require no iteration, do not depend ...

journal_title：Biometrics

authors： Keyfitz N,Frauenthal J

更新日期：1975-12-01 00:00:00

abstract：:Three properties of interest in bioavailability studies using compartmental models are the area under the concentration curve, the maximum concentration, and the time to maximum concentration. Methods are described for finding designs that minimize the variance of the estimates of these quantities in such a model. The...

journal_title：Biometrics

authors： Atkinson AC,Chaloner K,Herzberg AM,Juritz J

更新日期：1993-06-01 00:00:00

abstract：:Johnson and Wehrly (1978, Journal of the American Statistical Association 73, 602-606) and Wehrly and Johnson (1980, Biometrika 67, 255-256) show one way to construct the joint distribution of a circular and a linear random variable, or the joint distribution of a pair of circular random variables from their marginal ...

journal_title：Biometrics

authors： Fernández-Durán JJ

更新日期：2007-06-01 00:00:00

abstract：:Traditional studies of short-term air pollution health effects use time series data, while cohort studies generally focus on long-term effects. There is increasing interest in exploiting individual level cohort data to assess short-term health effects in order to understand the mechanisms and time scales of action. We...

journal_title：Biometrics

authors： Szpiro AA,Sheppard L,Adar SD,Kaufman JD

更新日期：2014-03-01 00:00:00

abstract：:A topic of current biometric discussion is whether stratification should be used in randomized clinical trials and, if so, which kind. An approach based upon randomization theory is used to evaluate pre- versus post-stratification. The results obtained relate specifically to the effect of the size of the clinical tria...

journal_title：Biometrics

authors： McHugh R,Matts J

更新日期：1983-03-01 00:00:00

abstract：:We consider the problem of testing for a difference in the probability of success from matched binary pairs. Starting with three standard inexact tests, the nuisance parameter is first estimated and then the residual dependence is eliminated by maximization, producing what I call an E+M P-value. The E+M P-value based ...

journal_title：Biometrics

authors： Lloyd CJ

更新日期：2008-09-01 00:00:00

abstract：:A general formula for the frequency of different recombinant gamete types, in terms of the underlying distribution of crossovers, is derived. This formula may be applied to any theoretical model of recombination in which it is assumed that there is no chromatid interference. Multiple-locus recombination data may be ev...

journal_title：Biometrics

authors： Risch N,Lange K

更新日期：1983-12-01 00:00:00

abstract：:This paper discusses interval estimation of the risk ratio (RR) between a secondary infection, given a primary infection, and the primary infection. Three asymptotic closed-form interval estimators are developed using Wald's test statistic, the logarithmic transformation, and Fieller's theorem. The performance of thes...

journal_title：Biometrics

authors： Lui KJ

更新日期：1998-06-01 00:00:00

abstract：:Exposure to high levels of air pollution during the pregnancy is associated with increased probability of preterm birth (PTB), a major cause of infant morbidity and mortality. New statistical methodology is required to specifically determine when a particular pollutant impacts the PTB outcome, to determine the role of...

journal_title：Biometrics

authors： Warren J,Fuentes M,Herring A,Langlois P

更新日期：2012-12-01 00:00:00

abstract：:In this paper alternative methods for estimating the relative potency, its confidence intervals, and testing for proportionality are developed for multivariate bioassays. The test and estimate are based on the smaller characteristic root and the corresponding characteristic vector of a 2 X 2 matrix. The same idea is a...

journal_title：Biometrics

authors： Srivastava MS

更新日期：1986-03-01 00:00:00

abstract：:For the analysis of time trends in incidence and mortality rates, the age-period-cohort (apc) model has became a widely accepted method. The considered data are arranged in a two-way table by age group and calendar period, which are mostly subdivided into 5- or 10-year intervals. The disadvantage of this approach is t...

journal_title：Biometrics

authors： Heuer C

更新日期：1997-03-01 00:00:00

abstract：:Bayesian experimental design is investigated for Bayesian analysis of nonlinear mixed-effects models. Existence of the posterior risk for parameter estimation is shown. When the same prior distribution is used for both design and inference, existence of the preposterior risk for design is also proven. If the prior dis...

journal_title：Biometrics

authors： Han C,Chaloner K

更新日期：2004-03-01 00:00:00

abstract：:The fitting of finite mixture models via the EM algorithm is considered for data which are available only in grouped form and which may also be truncated. A practical example is presented where a mixture of two doubly truncated log-normal distributions is adopted to model the distribution of the volume of red blood ce...

journal_title：Biometrics

authors： McLachlan GJ,Jones PN

更新日期：1988-06-01 00:00:00

abstract：:Integration of genomic data from multiple platforms has the capability to increase precision, accuracy, and statistical power in the identification of prognostic biomarkers. A fundamental problem faced in many multi-platform studies is unbalanced sample sizes due to the inability to obtain measurements from all the pl...

journal_title：Biometrics

authors： Chekouo T,Stingo FC,Doecke JD,Do KA

更新日期：2017-06-01 00:00:00