Abstract:
:We address one-sided stopping rules for clinical trials, or more generally, drug development programs, from a decision-theoretic point of view. If efficacy results are sufficiently negative then the trial will be stopped. But regardless of how positive the efficacy results are, the trial will continue in order to demonstrate safety. We show how sequential decisions should be made by a pharmaceutical company attempting to maximize its expected profits.
journal_name
Biometricsjournal_title
Biometricsauthors
Berry DA,Ho CHsubject
Has Abstractpub_date
1988-03-01 00:00:00pages
219-27issue
1eissn
0006-341Xissn
1541-0420journal_volume
44pub_type
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