Abstract:
:The "biometric school" founded by K. Pearson, F. Galton, and W. F. R. Weldon was concerned especially with heredity and variation, and between the wars "biometry" was not widely used as a general term for quantitative biology. The foundation of the Biometric Society encouraged this wider usage, and medical and biological statistics were seen to share a common methodology. In recent years, medical statistics has developed more rapidly, and this growth has been reflected in the contents of Biometrics. The author stresses the essential unity of the subject, the central core of which is the application of statistics in the life sciences. The Society should encourage contact with those workers in quantitative biology who are outside this central tradition.
journal_name
Biometricsjournal_title
Biometricsauthors
Armitage Psubject
Has Abstractpub_date
1985-12-01 00:00:00pages
823-33issue
4eissn
0006-341Xissn
1541-0420journal_volume
41pub_type
杂志文章相关文献
BIOMETRICS文献大全abstract:SUMMARY:A trend test is often employed to analyze ordered categorical data, in which a set of increasing scores is assigned a priori. There is a drawback in this approach, because how to choose a set of scores is not clear. There have been debates on which scores should be used (e.g., Graubard and Korn, 1987, Biometric...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2008.00992.x
更新日期:2008-12-01 00:00:00
abstract::We propose methods for Bayesian inference for a new class of semiparametric survival models with a cure fraction. Specifically, we propose a semiparametric cure rate model with a smoothing parameter that controls the degree of parametricity in the right tail of the survival distribution. We show that such a parameter ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2001.00383.x
更新日期:2001-06-01 00:00:00
abstract::Although the primary focus of Phase I clinical trials is to assess clinical pharmacology and possible toxicities, any information on the potential effect of treatment would be useful in helping to determine priorities between treatments for further study. We consider the scenario where data are routinely collected on ...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00
abstract::This paper presents a comparison of three methods of parameter estimation in analysis of linkage between a quantitative trait locus (QTL) and a marker locus: maximum likelihood, mean square for trait cumulative distribution function, and method of moments, employing simulated backcross data. The sensitivity of estimat...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1996-06-01 00:00:00
abstract:SUMMARY:Nonparametric regression models are proposed in the framework of ecological inference for exploratory modeling of disease prevalence rates adjusted for variables, such as age, ethnicity/race, and socio-economic status. Ecological inference is needed when a response variable and covariate are not available at th...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2008.00997.x
更新日期:2008-12-01 00:00:00
abstract::We consider the problem of estimating a population size from successive catches taken during a removal experiment and propose two estimating functions approaches, the traditional quasi-likelihood (TQL) approach for dependent observations and the conditional quasi-likelihood (CQL) approach using the conditional mean an...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.1999.01263.x
更新日期:1999-12-01 00:00:00
abstract::We study publication bias in meta-analysis by supposing there is a population (y, sigma) of studies which give treatment effect estimates y approximately N(theta, sigma(2)). A selection function describes the probability that each study is selected for review. The overall estimate of theta depends on the studies selec...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2006.00705.x
更新日期:2007-06-01 00:00:00
abstract::Asymptotic confidence bands for generalized nonlinear regression models are developed. These are based on a combination of the S method of Scheffe, together with the delta method which is used to approximate the mean function by a linear combination of the parameters. The approach can be used in any situation where la...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract::In problems with missing or latent data, a standard approach is to first impute the unobserved data, then perform all statistical analyses on the completed dataset--corresponding to the observed data and imputed unobserved data--using standard procedures for complete-data inference. Here, we extend this approach to mo...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341X.2005.031010.x
更新日期:2005-03-01 00:00:00
abstract::Several models for the course of microbial infections during the incubation period are examined. Each model fits sore throat incubation data very well. Together with the lack of precision of the resulting parameter estimates, this suggests that incubation data alone are insufficient for elucidating the finer details o...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1980-06-01 00:00:00
abstract::We propose a method to estimate the regression coefficients in a competing risks model where the cause-specific hazard for the cause of interest is related to covariates through a proportional hazards relationship and when cause of failure is missing for some individuals. We use multiple imputation procedures to imput...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2001.01191.x
更新日期:2001-12-01 00:00:00
abstract::In this paper we propose a new class of statistics to test a simple hypothesis against a family of alternatives characterized by a mixture model. Unlike the likelihood ratio statistic, whose large sample distribution is still unknown in this situation, these new statistics have a simple asymptotic distribution to whic...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.1999.00065.x
更新日期:1999-03-01 00:00:00
abstract::A Bayesian adaptive design is proposed for dose-finding in phase I/II clinical trials to incorporate the bivariate outcomes, toxicity and efficacy, of a new treatment. Without specifying any parametric functional form for the drug dose-response curve, we jointly model the bivariate binary data to account for the corre...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2006.00534.x
更新日期:2006-09-01 00:00:00
abstract::This paper considers the impact of bias in the estimation of the association parameters for longitudinal binary responses when there are drop-outs. A number of different estimating equation approaches are considered for the case where drop-out cannot be assumed to be a completely random process. In particular, standar...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2001.00015.x
更新日期:2001-03-01 00:00:00
abstract::This article presents a new approach for exploring the distribution of interindividual random effects in nonlinear mixed effect models. The approach introduces a spline function, which transforms an assumed normally distributed interindividual random effect to an arbitrary distribution approximating that of the data. ...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract::Brownie, Boos, and Hughes-Oliver (1990, Biometrics 46, 259-266) suggested a modification to the fixed-effects analysis of variance (ANOVA) F test for use in situations where treatments are likely to affect mean response while simultaneously increasing between-subject variability. These authors suggest that the modifie...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract::Recent advances in human genetics have led to a renewed interest in statistical methods for the detection of linkage from family data--for example, between marker loci and disease traits. Statistical analysis of linkage between two loci is carried out almost exclusively by means of the lod (log-odds) score test, equiv...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
abstract::Case-control studies offer a rapid and efficient way to evaluate hypotheses. On the other hand, proper selection of the controls is challenging, and the potential for selection bias is a major weakness. Valid inferences about parameters of interest cannot be drawn if selection bias exists. Furthermore, the selection b...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2001.01106.x
更新日期:2001-12-01 00:00:00
abstract::We describe an adaptive Bayesian design for a clinical trial of an experimental treatment for patients with hematologic malignancies who initially received an allogeneic bone marrow transplant but subsequently suffered a disease recurrence. Treatment consists of up to two courses of targeted immunotherapy followed by ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2002.00560.x
更新日期:2002-09-01 00:00:00
abstract::Directed acyclic graphical (DAG) models are increasingly employed in the study of physical and biological systems to model direct influences between variables. Identifying the graph from data is a challenging endeavor, which can be more reasonably tackled if the variables are assumed to satisfy a given ordering; in th...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12018
更新日期:2013-06-01 00:00:00
abstract::In genetic family studies, ages at onset of diseases are routinely collected. Often one is interested in assessing the familial association of ages at the onset of a certain disease type. However, when a competing risk is present and is related to the disease of interest, the usual measure of association by treating t...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2009.01372.x
更新日期:2010-12-01 00:00:00
abstract::Thanks to the growing interest in personalized medicine, joint modeling of longitudinal marker and time-to-event data has recently started to be used to derive dynamic individual risk predictions. Individual predictions are called dynamic because they are updated when information on the subject's health profile grows ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12232
更新日期:2015-03-01 00:00:00
abstract::The Colton model for the choice between two medical treatments is studied, with the additional assumption that there is a time lag between the administration of the treatments and the availability of the responses. Two simple procedures are suggested for dealing with patients who arrive during the waiting period, caus...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1981-03-01 00:00:00
abstract::We present a class of simple designs that can be used in early dose-finding studies in HIV. Such designs, in contrast with Phase I designs in cancer, have a lot of the Phase II flavor about them. Information on efficacy is obtained during the trial and is as important as that relating to toxicity. The designs proposed...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2001.01018.x
更新日期:2001-12-01 00:00:00
abstract::R. A. Fisher is widely respected for his contributions to both statistics and genetics. For instance, his 1930 text on The Genetical Theory of Natural Selection remains a watershed contribution in that area. Fisher's subsequent research led him to study the work of (Johann) Gregor Mendel, the 19th century monk who fir...
journal_title:Biometrics
pub_type: 传,历史文章,杂志文章,评审
doi:
更新日期:1990-12-01 00:00:00
abstract::Identifying factors associated with increased medical cost is important for many micro- and macro-institutions, including the national economy and public health, insurers and the insured. However, assembling comprehensive national databases that include both the cost and individual-level predictors can prove challengi...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12464
更新日期:2016-09-01 00:00:00
abstract::A semiparametric estimate of an average regression effect with right-censored failure time data has recently been proposed under the Cox-type model where the regression effect beta(t) is allowed to vary with time. In this article, we derive a simple algebraic relationship between this average regression effect and a m...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2001.00875.x
更新日期:2001-09-01 00:00:00
abstract::Life-table methodology for interval-censored survival times is used to estimate marginal survival probabilities from data consisting of independent cohorts of correlated responses. We restrict our attention to situations where response times within cohorts are exchangeable and the marginal survival distributions are t...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract::We consider a capture-recapture model in which capture probabilities vary with time and with behavioral response. Two inference procedures are developed under the assumption that recapture probabilities bear a constant relationship to initial capture probabilities. These two procedures are the maximum likelihood metho...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2000.00427.x
更新日期:2000-06-01 00:00:00
abstract::A stochastic model is presented for the analysis of incomplete repeated-measures experiments. The general linear model is used to relate the response measures to other variables which are thought to account for inherent variation; an autoregressive moving average (ARMA) time series representation is used to model dist...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00