Abstract:
SUMMARY:A trend test is often employed to analyze ordered categorical data, in which a set of increasing scores is assigned a priori. There is a drawback in this approach, because how to choose a set of scores is not clear. There have been debates on which scores should be used (e.g., Graubard and Korn, 1987, Biometrics 43, 471-476; Ivanova and Berger, 2001, Biometrics 57, 567-570; Senn, 2007, Biometrics 63, 296-298). Conflicting conclusions are often obtained with different sets of scores. Two approaches, which have been applied to genetic case-control studies, are appealing for ordered categorical data, because they take into account the natural order in the data, are score independent, and not contingent on asymptotic theory. These two approaches are applied to a prospective study for detecting association between maternal drinking and congenital malformations.
journal_name
Biometricsjournal_title
Biometricsauthors
Zheng Gdoi
10.1111/j.1541-0420.2008.00992.xsubject
Has Abstractpub_date
2008-12-01 00:00:00pages
1276-9issue
4eissn
0006-341Xissn
1541-0420pii
BIOM992journal_volume
64pub_type
杂志文章相关文献
BIOMETRICS文献大全abstract::We derive semiparametric methods for estimating and testing treatment effects when censored recurrent event data are available over multiple periods. These methods are based on estimating functions motivated by a working "mixed-Poisson" assumption under which conditioning can eliminate subject-specific random effects....
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2005.00357.x
更新日期:2005-09-01 00:00:00
abstract::Despite major methodological developments, Bayesian inference in Gaussian graphical models remains challenging in high dimension due to the tremendous size of the model space. This article proposes a method to infer the marginal and conditional independence structures between variables by multiple testing, which bypas...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.13064
更新日期:2019-12-01 00:00:00
abstract::The validation of surrogate endpoints has been studied by Prentice (1989, Statistics in Medicine 8, 431-440) and Freedman, Graubard, and Schatzkin (1992, Statistics in Medicine 11, 167-178). We extended their proposals in the cases where the surrogate and the final endpoints are both binary or normally distributed. Le...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
abstract::High throughput technologies, such as gene expression arrays and protein mass spectrometry, allow one to simultaneously evaluate thousands of potential biomarkers that could distinguish different tissue types. Of particular interest here is distinguishing between cancerous and normal organ tissues. We consider statist...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/1541-0420.00016
更新日期:2003-03-01 00:00:00
abstract::Identifying disease-associated changes in DNA methylation can help us gain a better understanding of disease etiology. Bisulfite sequencing allows the generation of high-throughput methylation profiles at single-base resolution of DNA. However, optimally modeling and analyzing these sparse and discrete sequencing data...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.13307
更新日期:2020-05-21 00:00:00
abstract::Estimates of waterfowl demographic parameters often come from resighting studies where birds fit with individually identifiable neck collars are resighted at a distance. Concerns have been raised about the effects of collar loss on parameter estimates, and the reliability of extrapolating from collared individuals to ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341X.2004.00245.x
更新日期:2004-12-01 00:00:00
abstract::Epidemiolgic studies have strongly suggested that a vast majority (80-90%) of cancers are caused by radiation, chemical and biologic agents; the remainder result from endogenous or genetic factors. Biologically, cancer is most probably the end result of a complex multistage process and therefore may be due to a sequen...
journal_title:Biometrics
pub_type: 杂志文章,评审
doi:
更新日期:1982-03-01 00:00:00
abstract::This article demonstrates semiparametric maximum likelihood estimation of a nonlinear growth model for fish lengths using imprecisely measured ages. Data on the species corvina reina, found in the Gulf of Nicoya, Costa Rica, consist of lengths and imprecise ages for 168 fish and precise ages for a subset of 16 fish. T...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2002.00448.x
更新日期:2002-06-01 00:00:00
abstract::This article proposes an efficient approach to screening genes associated with a phenotypic variable of interest in genomic studies with subgroups. In order to capture and detect various association profiles across subgroups, we flexibly estimate the underlying effect size distribution across subgroups using a semi-pa...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12716
更新日期:2018-03-01 00:00:00
abstract::We assess the efficiency of balanced treatment allocation methods in clinical trials for comparing treatments with respect to survival. We compare optimal designs for each of three standard survival analysis techniques (maximum partial likelihood estimation, log-rank test, exponential regression) with balanced designs...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1988-09-01 00:00:00
abstract::In many medical experiments, data are collected across time, over a number of similar trials, or over a number of experimental units. As is the case of neuron spike train studies, these data may be in the form of counts of events per unit of time. These counts may be correlated within each trial. It is often of intere...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract::In this study we are concerned with the construction of confidence intervals for the conditional probability of misallocation associated with Anderson's classification statistics, W. The available methods of computing confidence intervals for the conditional probability are not satisfactory in practice, mainly because...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1975-03-01 00:00:00
abstract::Because the number of patients waiting for organ transplants exceeds the number of organs available, a better understanding of how transplantation affects the distribution of residual lifetime is needed to improve organ allocation. However, there has been little work to assess the survival benefit of transplantation f...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12084
更新日期:2013-12-01 00:00:00
abstract::An adjusted rank correlation test is proposed as a technique for identifying publication bias in a meta-analysis, and its operating characteristics are evaluated via simulations. The test statistic is a direct statistical analogue of the popular "funnel-graph." The number of component studies in the meta-analysis, the...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract::The feasibility and cost-effectiveness of estimation of kappa using a case-control method of sampling, proposed by Jannarone, Macera, and Garrison (1987, Biometrics 43, 433-437), is provided support. However, in this article unrealistic assumptions in their presentation are identified and more general results for more...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1990-03-01 00:00:00
abstract::A broad approach to the design of Phase I clinical trials for the efficient estimation of the maximum tolerated dose is presented. The method is rooted in formal optimal design theory and involves the construction of constrained Bayesian c- and D-optimal designs. The imposed constraint incorporates the optimal design ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/1541-0420.00069
更新日期:2003-09-01 00:00:00
abstract::Life-table methodology for interval-censored survival times is used to estimate marginal survival probabilities from data consisting of independent cohorts of correlated responses. We restrict our attention to situations where response times within cohorts are exchangeable and the marginal survival distributions are t...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract::The approach to early termination for efficacy in a trial where events occur over time but the primary question of interest relates to a long-term binary endpoint is not straightforward. This article considers comparison of treatment groups with Kaplan-Meier (KM) proportions evaluated at increasing times from randomiz...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2007.00874.x
更新日期:2008-03-01 00:00:00
abstract::We consider hidden Markov models as a versatile class of models for weakly dependent random phenomena. The topic of the present paper is likelihood-ratio testing for hidden Markov models, and we show that, under appropriate conditions, the standard asymptotic theory of likelihood-ratio tests is valid. Such tests are c...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2000.00742.x
更新日期:2000-09-01 00:00:00
abstract::Markov chain models are frequently used for studying event histories that include transitions between several states. An empirical transition matrix for nonhomogeneous Markov chains has previously been developed, including a detailed statistical theory based on counting processes and martingales. In this article, we s...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2001.00993.x
更新日期:2001-12-01 00:00:00
abstract::Morrissey and Spiegelman (1999, Biometrics 55, 338 344) provided a comparative study of adjustment methods for exposure misclassification in case-control studies equipped with an internal validation sample. In addition to the maximum likelihood (ML) approach, they considered two intuitive procedures based on proposals...
journal_title:Biometrics
pub_type: 评论,杂志文章
doi:10.1111/j.0006-341x.2002.1034_1.x
更新日期:2002-12-01 00:00:00
abstract::Cancer population studies based on cancer registry databases are widely conducted to address various research questions. In general, cancer registry databases do not collect information on cause of death. The net survival rate is defined as the survival rate if a subject would not die for any causes other than cancer....
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12568
更新日期:2017-03-01 00:00:00
abstract::In an effort to determine whether a particular treatment causes a particular outcome event, data are obtained from a database system that records events when they occur, and for such events, the system records exposure to the treatment. That is, the system records information about cases. The system provides no inform...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341X.2005.030920.x
更新日期:2005-03-01 00:00:00
abstract::Patients who were previously treated for prostate cancer with radiation therapy are monitored at regular intervals using a laboratory test called Prostate Specific Antigen (PSA). If the value of the PSA test starts to rise, this is an indication that the prostate cancer is more likely to recur, and the patient may wis...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2012.01823.x
更新日期:2013-03-01 00:00:00
abstract::Heart rate oscillates in synchrony with respiration. Several methods have been employed to assess this 'sinus arrhythmia', as an index of autonomic nervous system function. This paper proposes a new, easily computed measure, R, which is relatively resistant to the major nonrespiratory sources of variation, including p...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1984-09-01 00:00:00
abstract::Receiver operating characteristic (ROC) curves are frequently used to assess the usefulness of diagnostic markers. When several diagnostic markers are available, they can be combined by a best linear combination: that is, when the area under the ROC curve of this combination is maximized among all possible linear comb...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1997-06-01 00:00:00
abstract::Covariate-specific receiver operating characteristic (ROC) curves are often used to evaluate the classification accuracy of a medical diagnostic test or a biomarker, when the accuracy of the test is associated with certain covariates. In many large-scale screening tests, the gold standard is subject to missingness due...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2011.01562.x
更新日期:2011-09-01 00:00:00
abstract::Diggle and Kenward (1994, Applied Statistics 43, 49-93) proposed a selection model for continuous longitudinal data subject to nonrandom dropout. It has provoked a large debate about the role for such models. The original enthusiasm was followed by skepticism about the strong but untestable assumptions on which this t...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2001.00007.x
更新日期:2001-03-01 00:00:00
abstract::Functional mapping is a useful tool for mapping quantitative trait loci (QTL) that control dynamic traits. It incorporates mathematical aspects of biological processes into the mixture model-based likelihood setting for QTL mapping, thus increasing the power of QTL detection and the precision of parameter estimation. ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2008.01063.x
更新日期:2009-03-01 00:00:00
abstract::In a period starting around 2007, the Hand, Foot, and Mouth Disease (HFMD) became wide-spreading in China, and the Chinese public health was seriously threatened. To prevent the outbreak of infectious diseases like HFMD, effective disease surveillance systems would be especially helpful to give signals of disease outb...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12301
更新日期:2015-09-01 00:00:00