Abstract：
:Suppose that the response variable in a well-executed clinical or observational study to evaluate a treatment is the time to a certain event, and a set of baseline covariates or predictors was collected for each study patient. Furthermore, suppose that a significant number of study patients had nontrivial, long-term adverse effects from the treatment. A commonly posed question is how to use these covariates from the study to identify future patients who would (or would not) benefit from the treatment. In this article, we present "point" and "interval" estimates for the set of covariate or predictor vectors associated with a specific patient survival status, e.g., long- (or short-) term survival, in the presence of censoring. These estimates can be easily displayed on a two-dimensional plane, even for the case with high-dimensional covariate vectors. These simple numerical and graphical procedures provide useful information for patient management and/or the design of future studies, which are key issues in pharmacogenomics with genetic markers. The new proposal is illustrated with a data set from a cancer study for treating multiple myeloma.
journal_name
Biometricsjournal_title
Biometricsauthors
Tian L,Wang W,Wei LJdoi
10.1111/j.0006-341x.2003.00116.xsubject
Has Abstractpub_date
2003-12-01 00:00:00pages
1008-15issue
4eissn
0006-341Xissn
1541-0420journal_volume
59pub_type
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