Abstract:
:Observational studies are often in peril of unmeasured confounding. Instrumental variable analysis is a method for controlling for unmeasured confounding. As yet, theory on instrumental variable analysis of censored time-to-event data is scarce. We propose a pseudo-observation approach to instrumental variable analysis of the survival function, the restricted mean, and the cumulative incidence function in competing risks with right-censored data using generalized method of moments estimation. For the purpose of illustrating our proposed method, we study antidepressant exposure in pregnancy and risk of autism spectrum disorder in offspring, and the performance of the method is assessed through simulation studies.
journal_name
Biometricsjournal_title
Biometricsauthors
Kjaersgaard MI,Parner ETdoi
10.1111/biom.12451subject
Has Abstractpub_date
2016-06-01 00:00:00pages
463-72issue
2eissn
0006-341Xissn
1541-0420journal_volume
72pub_type
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