Abstract:
:Pocock et al. (2012, European Heart Journal 33, 176-182) proposed a win ratio approach to analyzing composite endpoints comprised of outcomes with different clinical priorities. In this article, we establish a statistical framework for this approach. We derive the null hypothesis and propose a closed-form variance estimator for the win ratio statistic in all pairwise matching situation. Our simulation study shows that the proposed variance estimator performs well regardless of the magnitude of treatment effect size and the type of the joint distribution of the outcomes.
journal_name
Biometricsjournal_title
Biometricsauthors
Luo X,Tian H,Mohanty S,Tsai WYdoi
10.1111/biom.12225subject
Has Abstractpub_date
2015-03-01 00:00:00pages
139-145issue
1eissn
0006-341Xissn
1541-0420journal_volume
71pub_type
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