Abstract:
:Microarray technology allows the monitoring of expression levels of thousands of genes simultaneously. A semiparametric location and scale model is proposed to model gene expression levels for normalization and significance analysis purposes. Robust estimation based on weighted least absolute deviation regression and significance analysis based on the weighted bootstrap are investigated. The proposed approach naturally combines normalization and significance analysis, and incorporates the variations due to normalization into the significance analysis properly. A small simulation study is used to compare finite sample performance of the proposed approach with alternatives. We also demonstrate the proposed method with a real dataset.
journal_name
Biometricsjournal_title
Biometricsauthors
Ma S,Kosorok MR,Huang J,Xie H,Manzella L,Soares MBdoi
10.1111/j.1541-0420.2005.00452.xsubject
Has Abstractpub_date
2006-06-01 00:00:00pages
555-61issue
2eissn
0006-341Xissn
1541-0420pii
BIOM452journal_volume
62pub_type
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