Abstract:
:If the regulatory requirements are symmetrical, the use of symmetrical confidence intervals as a decision rule for bioequivalence assessment leads, as shown by simulations, to better level properties and an inferior power compared to a rule based on shortest confidence intervals. A choice between these two approaches will have to depend on a loss function. For asymmetric regulatory requirements, symmetrical confidence intervals should not be used; however, a decision can still be based on posterior probabilities, pr (theta epsilon [r1, r2]/x), or shortest confidence intervals. For purposes of inference, presentation and interpretation of results, we think that the use of symmetrical confidence intervals alone can be misleading and we therefore recommend that the posterior probabilities and densities, or at least the shortest confidence intervals, be given.
journal_name
Biometricsjournal_title
Biometricsauthors
Mandallaz D,Mau Jsubject
Has Abstractpub_date
1981-06-01 00:00:00pages
213-22issue
2eissn
0006-341Xissn
1541-0420journal_volume
37pub_type
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