Abstract:
:The distance between homologous DNA sequences of two species is proposed to be -1/4 ln[det(P)], where P is the conditional probability matrix specifying the proportions of the various nucleotides in the second sequence, corresponding to each of the four nucleotides in the first sequence. A probability model is described which supports this choice of distance. Distance measures based on a constant evolutionary rate assumption are described and compared with the proposed measure. Sampling properties of both types of distance are examined and we conclude by applying the distance measures to mitochondrial DNA sequences of the hominoids.
journal_name
Biometricsjournal_title
Biometricsauthors
Barry D,Hartigan JAsubject
Has Abstractpub_date
1987-06-01 00:00:00pages
261-76issue
2eissn
0006-341Xissn
1541-0420journal_volume
43pub_type
杂志文章相关文献
BIOMETRICS文献大全abstract::For patients on dialysis, hospitalizations remain a major risk factor for mortality and morbidity. We use data from a large national database, United States Renal Data System, to model time-varying effects of hospitalization risk factors as functions of time since initiation of dialysis. To account for the three-level...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.13205
更新日期:2020-09-01 00:00:00
abstract::Jolliffe and Jolliffe (1997, Biometrics 53, 1136-1142) proposed various models for data from an experiment on memory in coal tits. This article describes an alternative model, which fits equally well and which may be simpler to interpret. ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.1999.00660.x
更新日期:1999-06-01 00:00:00
abstract::I discuss diagnostic methods for discriminant analysis. The equivalence with linear regression is noted and regression diagnostics are considered. The leverage is a function of the linear discriminant function and the Mahalanobis distance of the observation from the group mean. The distribution of this distance is app...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00
abstract::In this article, we propose a Bayesian approach to phase I/II dose-finding oncology trials by jointly modeling a binary toxicity outcome and a continuous biomarker expression outcome. We apply our method to a clinical trial of a new gene therapy for bladder cancer patients. In this trial, the biomarker expression indi...
journal_title:Biometrics
pub_type: 临床试验,杂志文章
doi:10.1111/j.1541-0420.2005.00314.x
更新日期:2005-06-01 00:00:00
abstract::The approach to early termination for efficacy in a trial where events occur over time but the primary question of interest relates to a long-term binary endpoint is not straightforward. This article considers comparison of treatment groups with Kaplan-Meier (KM) proportions evaluated at increasing times from randomiz...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2007.00874.x
更新日期:2008-03-01 00:00:00
abstract::Exposure to high levels of air pollution during the pregnancy is associated with increased probability of preterm birth (PTB), a major cause of infant morbidity and mortality. New statistical methodology is required to specifically determine when a particular pollutant impacts the PTB outcome, to determine the role of...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2012.01774.x
更新日期:2012-12-01 00:00:00
abstract::A general formula for the frequency of different recombinant gamete types, in terms of the underlying distribution of crossovers, is derived. This formula may be applied to any theoretical model of recombination in which it is assumed that there is no chromatid interference. Multiple-locus recombination data may be ev...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1983-12-01 00:00:00
abstract::Matched case-control designs are commonly used in epidemiologic studies for increased efficiency. These designs have recently been introduced to the setting of modern imaging and genomic studies, which are characterized by high-dimensional covariates. However, appropriate statistical analyses that adjust for the match...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12113
更新日期:2014-03-01 00:00:00
abstract::This note discusses the use of capture-mark-recapture methods and log-linear, linear, product models for incomplete tables (Espeland, 1986, Communications in Statistics--Simulation and Computing 15, 405-424) to estimate completeness of reporting in a disease registry and to estimate incompleteness-adjusted incidence r...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
abstract::Consider a collection of spatially clustered objects where the clusters are geographically rare. Of interest is estimation of the total number of objects on the site from a sample of plots of equal size. Under these spatial conditions, adaptive cluster sampling of plots is generally useful in improving efficiency in e...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2000.00503.x
更新日期:2000-06-01 00:00:00
abstract::An individual's health condition can affect the frequency and intensity of episodes that can occur repeatedly and that may be related to an event time of interest. For example, bleeding episodes during pregnancy may indicate problems predictive of preterm delivery. Motivated by this application, we propose a joint mod...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2006.00720.x
更新日期:2007-06-01 00:00:00
abstract::In the calibration problem, the need to construct a confidence interval to estimate the unknown chi 0 arises when the null hypothesis of zero slope is rejected. Otherwise, the resulting confidence interval will be infinite to reflect the fact that the slope of the regression line may be zero. Under the condition of re...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00
abstract::The standard approach to inference for random effects meta-analysis relies on approximating the null distribution of a test statistic by a standard normal distribution. This approximation is asymptotic on k, the number of studies, and can be substantially in error in medical meta-analyses, which often have only a few ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.1999.00732.x
更新日期:1999-09-01 00:00:00
abstract::Cohort case-control design is an efficient and economical design to study risk factors for disease incidence or mortality in a large cohort. In the last few decades, a variety of cohort case-control designs have been developed and theoretically justified. These designs have been exclusively applied to the analysis of ...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2002.00764.x
更新日期:2002-12-01 00:00:00
abstract::A common measure in clinical trials and epidemiologic studies is the number of events such as seizures, hospitalizations, or bouts of disease. Frequently, a binary measure of severity for each event is available but is not incorporated in the analysis. This paper proposes methodology for jointly modeling the number of...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract::We propose a generalized linear mixed model to estimate and test marginal effects on titers repeatedly measured by serial dilution assays. The link is log-log and the titer is assumed to follow a gamma distribution. The parameters are estimated by generalized estimating equations. The marginal effects are tested by me...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract::A multiple toxicity model for the quantal response of organisms is constructed based on an existing bivariate theory. The main assumption is that the tolerances follow a multivariate normal distribution function. However, any monotone tolerance distribution can be applied by mapping the integration region in the n-dim...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1985-09-01 00:00:00
abstract::We propose a similarity-based regression method to detect associations between traits and multimarker genotypes. The model regresses similarity in traits for pairs of "unrelated" individuals on their haplotype similarities, and detects the significance by a score test for which the limiting distribution is derived. Th...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2008.01176.x
更新日期:2009-09-01 00:00:00
abstract::In the field of cardio-thoracic surgery, valve function is monitored over time after surgery. The motivation for our research comes from a study which includes patients who received a human tissue valve in the aortic position. These patients are followed prospectively over time by standardized echocardiographic assess...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12814
更新日期:2018-06-01 00:00:00
abstract::Image-on-image regression analysis, using images to predict images, is a challenging task, due to (1) the high dimensionality and (2) the complex spatial dependence structures in image predictors and image outcomes. In this work, we propose a novel image-on-image regression model, by extending a spatial Bayesian laten...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.13420
更新日期:2020-12-27 00:00:00
abstract::Experiments that longitudinally collect RNA sequencing (RNA-seq) data can provide transformative insights in biology research by revealing the dynamic patterns of genes. Such experiments create a great demand for new analytic approaches to identify differentially expressed (DE) genes based on large-scale time-course c...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.13144
更新日期:2020-03-01 00:00:00
abstract::This article introduces an original methodology based on empirical likelihood, which aims at combining different food contamination and consumption surveys to provide risk managers with a risk measure, taking into account all the available information. This risk index is defined as the probability that exposure to a c...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.1541-0420.2008.01051.x
更新日期:2009-03-01 00:00:00
abstract::We investigate two-stage parametric and two-stage semi-parametric estimation procedures for the association parameter in copula models for bivariate survival data where censoring in either or both components is allowed. We derive asymptotic properties of the estimators and compare their performance by simulations. Bot...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract::Dose-response models are intensively used in herbicide bioassays. Despite recent advancements in the development of new herbicides, statistical analyses are commonly based on asymptotic approximations that are sometimes poor. This paper presents the use of recent results in higher order asymptotics for likelihood-base...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2000.01204.x
更新日期:2000-12-01 00:00:00
abstract::In this paper, a Markov process is developed as a mathematical model to study the general problem of quality control monitoring. This approach was previously used by Arnold (1970) in development of sampling plans to study the water quality monitoring of streams. Arnold considered the expected sample size required for ...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1977-03-01 00:00:00
abstract::The search for an optimal dose of a drug has been investigated in a sequential setting to ensure the safety level by Eichhorn and Zacks (1973, Journal of the American Statistical Association 68, 594-598; 1981, Communications in Statistics--Theory and Methods A10, 931-953), Eichhorn (1974, Communications in Statistics ...
journal_title:Biometrics
pub_type: 临床试验,杂志文章
doi:
更新日期:1989-06-01 00:00:00
abstract::The aim of this study is to estimate incidence rates of onchocerciasis from skin-snip biopsies, based on incomplete data obtained in field surveys, with consideration of false negatives. The method of maximum likelihood is employed and the effect of false negatives on the incidence rates is discussed. ...
journal_title:Biometrics
pub_type: 杂志文章
doi:
更新日期:1984-06-01 00:00:00
abstract::Some covariate-adaptive randomization methods have been used in clinical trials for a long time, but little theoretical work has been done about testing hypotheses under covariate-adaptive randomization until Shao et al. (2010) who provided a theory with detailed discussion for responses under linear models. In this a...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12062
更新日期:2013-12-01 00:00:00
abstract::We consider inference for the reaction rates in discretely observed networks such as those found in models for systems biology, population ecology, and epidemics. Most such networks are neither slow enough nor small enough for inference via the true state-dependent Markov jump process to be feasible. Typically, infere...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/biom.12152
更新日期:2014-06-01 00:00:00
abstract::In this article, we present an estimation approach for solving nonlinear constrained generalized estimating equations that can be implemented using object-oriented software for nonlinear programming, such as nlminb in Splus or fmincon and lsqnonlin in Matlab. We show how standard estimating equation theory includes th...
journal_title:Biometrics
pub_type: 杂志文章
doi:10.1111/j.0006-341x.2000.01268.x
更新日期:2000-12-01 00:00:00