Asynchronous distance between homologous DNA sequences.

Abstract:

:The distance between homologous DNA sequences of two species is proposed to be -1/4 ln[det(P)], where P is the conditional probability matrix specifying the proportions of the various nucleotides in the second sequence, corresponding to each of the four nucleotides in the first sequence. A probability model is described which supports this choice of distance. Distance measures based on a constant evolutionary rate assumption are described and compared with the proposed measure. Sampling properties of both types of distance are examined and we conclude by applying the distance measures to mitochondrial DNA sequences of the hominoids.

journal_name

Biometrics

journal_title

Biometrics

authors

Barry D,Hartigan JA

subject

Has Abstract

pub_date

1987-06-01 00:00:00

pages

261-76

issue

2

eissn

0006-341X

issn

1541-0420

journal_volume

43

pub_type

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