Abstract:
:Glucokinases (Glks) are enzymes widely distributed in all three domains of life. They are located at the beginning of the glycolytic pathway and are responsible for the glucose phosphorylation from various phosphate group donors such as ATP, ADP and polyphosphate. So far, there are eight crystallized Glks, and at least one belongs to each of the three reported Glk families. Structural studies have elucidated the mechanism for Glk action and multimerization. Cloning, overexpression and biochemical characterization have demonstrated the wide diversity of these enzymes. As reported for various microorganisms, in addition to their catalytic activity, some Glks, possessing ROK (Repressor Orf Kinases) motifs, also display a regulatory role. This function has been associated to the mechanisms of carbon catabolite regulation, morphological differentiation and antibiotic production. The present review covers the classification, detailed tertiary structure, mechanism of action, biochemical characterization and some regulatory aspects of bacterial Glks.
journal_name
Arch Biochem Biophysjournal_title
Archives of biochemistry and biophysicsauthors
Romero-Rodríguez A,Ruiz-Villafán B,Rocha-Mendoza D,Manzo-Ruiz M,Sánchez Sdoi
10.1016/j.abb.2015.05.001subject
Has Abstractpub_date
2015-07-01 00:00:00pages
1-10eissn
0003-9861issn
1096-0384pii
S0003-9861(15)00221-0journal_volume
577-578pub_type
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